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Institution

Indian Institute of Technology Guwahati

EducationGuwahati, Assam, India
About: Indian Institute of Technology Guwahati is a education organization based out in Guwahati, Assam, India. It is known for research contribution in the topics: Adsorption & Catalysis. The organization has 6933 authors who have published 17102 publications receiving 257351 citations.


Papers
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Journal ArticleDOI
TL;DR: Performed studies confirmed CS-PVP-CNWs based release system can as a potential candidate for wound dressing applications with sustained drug release with high biocompatibility with excellent antibacterial activities.
Abstract: This study describes the preparation of composite film using chitosan (CS) and polyvinylpyrrolidone (PVP) with incorporated cellulose nanowhiskers (CNWs) for drug delivery application. CNWs were prepared by acid hydrolysis of cellulose with sulfuric acid. Field emission scanning electron microscopy studies revealed nanofibrous morphology of CNWs with 20-30 nm diameter and 200-250 nm in length. X-ray powder diffraction analysis confirmed highly crystalline nature of CNWs with 92.81% crystallinity. Incorporation of CNWs enhanced the thermal and mechanical properties of films. Fourier transform infrared spectroscopy data showed physical interactions between polymer-polymer and polymer-drug. Films prepared with CNWs showed improved swelling behavior which resulted in sustained drug release from polymeric matrix. In vitro curcumin release data were fitted with two-step release model; Step 1 as desorption from the outer surface of the film, and Step 2 as diffusion from within the film and subsequent desorption. The release kinetics confirmed biphasic release profile with different release rates along with diffusion controlled curcumin release. Prepared films showed high biocompatibility with excellent antibacterial activities. Overall, the performed studies confirmed CS-PVP-CNWs based release system can as a potential candidate for wound dressing applications with sustained drug release. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2391-2404, 2017.

101 citations

Journal ArticleDOI
TL;DR: In this tandem catalytic synthesis of 3-aroylindoles both C-C and C-O bonds are installed at the expense of two sp(3) C-H bond cleavages.

101 citations

Journal ArticleDOI
TL;DR: In this article, the effect of a single formyl group that can efficiently transform an aggregation caused quenching (ACQ) system into an AIEEgenic system (NIBD) by strengthening the restriction of intramolecular motion (RIM) of rigid aromatic cores is investigated.
Abstract: Restriction of intramolecular motion (RIM) of rigid aromatic cores is the most universal mechanism so far that can successfully explain almost all AIE/AIEEgenic systems. By designing two novel naphthalimide derivatives (NIB and NIBD), we experimentally demonstrated the effect of a single formyl group that can efficiently transform an aggregation caused quenching (ACQ) system (NIB) into an AIEEgenic system (NIBD) by strengthening the RIM process. Besides, the newly designed naphthalimide AIEEgen (NIBD) accomplished ultrasensitive detection of hydrazine at the parts per trillion level (LOD/81 ppt) in aqueous media with high selectivity and enormous improvement over the existing state of the art. An exceptional sensitivity is also achieved in the vapor phase (LOD/0.003%) using a Whatman paper strip based portable device for simple and cost-effective on-site detection. The detection mechanism involved a reaction-based spontaneous formation of a non-fluorescent hydrazone Schiff base derivative (NIBDH). The in vitro potentiality of the AIEEgenic probe was also demonstrated in two mammalian cell lines i.e. HeLa (human cervical cancer cell line) and HEK293T (Human embryonic kidney cell line that expresses a mutant version of the SV40 large T antigen). Owing to the highly selective formation of the hydrazone Schiff base complex with hydrazine, NIBD responds to the existence of hydrazine in both these cell lines without any interference from other biologically rich metal ions and amino acids. These outcomes could initiate a much wider use of formyl group induced condensed state emission and a key hypothesis that could generate newer avenues for ACQ to AIEE transformations for several practical applications including hydrazone Schiff base complexation for probing and manipulating hydrazine biology associated with several metabolic activities.

101 citations

Journal ArticleDOI
J. P. Lees1, V. Poireau1, V. Tisserand1, J. Garra Tico2  +359 moreInstitutions (80)
TL;DR: In this paper, the authors studied the process e +e −→J/ψπ +π - with initial-state-radiation events produced at the PEP-II asymmetric-energy collider.
Abstract: We study the process e +e -→J/ψπ +π - with initial-state-radiation events produced at the PEP-II asymmetric-energy collider. The data were recorded with the BABAR detector at center-of-mass energies 10.58 and 10.54 GeV, and correspond to an integrated luminosity of 454fb -1. We investigate the J/ψπ +π - mass distribution in the region from 3.5 to 5.5GeV/c2. Below 3.7GeV/c2 the ψ(2S) signal dominates, and above 4GeV/c2 there is a significant peak due to the Y(4260). A fit to the data in the range 3.74-5.50GeV/c2 yields a mass value 4245±5(stat)±4(syst)MeV/c2 and a width value 114-15+16(stat) ±7(syst)MeV for this state. We do not confirm the report from the Belle Collaboration of a broad structure at 4.01GeV/c2. In addition, we investigate the π +π - system which results from Y(4260) decay. © 2012 American Physical Society.

101 citations

Journal ArticleDOI
TL;DR: It is shown here that iron( IV)-tosylimido complex is much more reactive with sulfides than the corresponding iron(IV)-oxo complex; however, the reverse trend is obtained for hydrogen atom abstraction reactions.
Abstract: Nature often utilizes molecular oxygen for oxidation reactions through monoxygenases and dioxygenases. In many of these systems, a high-valent iron(IV)-oxo active species is found. In recent years, evidence has accumulated of possible iron(IV)-imido and iron(V)-nitrido intermediates in enzymatic catalysis, although little is known about their activity. In this work, we report a detailed combined kinetics and computational study on the difference in reactivity and chemical properties of nonheme iron(IV)-oxo compared with iron(IV)-tosylimido. We show here that iron(IV)-tosylimido complex is much more reactive with sulfides than the corresponding iron(IV)-oxo complex; however, the reverse trend is obtained for hydrogen atom abstraction reactions. The latter proceed with a relatively small kinetic isotope effect of kH/kD = 7 for the iron(IV)-tosylimido complex. Moreover, a Hammett analysis of hydrogen atom abstraction from para-X-benzyl alcohol reveals a slope of close to zero for the iron(IV)-oxo, whereas a ...

101 citations


Authors

Showing all 7128 results

NameH-indexPapersCitations
Jasvinder A. Singh1762382223370
Dipanwita Dutta1431651103866
Sanjay Gupta9990235039
Santosh Kumar80119629391
Subrata Ghosh7884132147
Rishi Raj7856922423
B. Bhuyan7365821275
Ravi Shankar6667219326
Ashutosh Sharma6657016100
Gautam Biswas6372116146
Sam P. de Visser6225613820
Surendra Nadh Somala6114428273
Manish Kumar61142521762
Mihir Kumar Purkait572679812
Ajaikumar B. Kunnumakkara5720120025
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023118
2022365
20212,032
20201,947
20191,866
20181,647