Indian Institute of Technology Indore

About: Indian Institute of Technology Indore is a education organization based out in Indore, Madhya Pradesh, India. It is known for research contribution in the topics: Fading & Support vector machine. The organization has 1606 authors who have published 4803 publications receiving 66500 citations.

Experimental investigation of the effect of inclination angle on the performance of phase change material based finned heat sink

Abstract: This paper presents an experimental study to investigate the effect of inclination angle on the thermal performance of phase change material (PCM) based heat sinks without and with plate fins. Paraffin wax with melting temperature range 58–62 °C is used as PCM. Three different heat flux values such as 1.3, 2.0 and 2.7 kW/m2 are chosen to analyze the effect of heat flux variation on the melting of PCM. Also, tests are carried out with various angles of inclination from 0o to 90o at increments of 15o. The solid-liquid interface position is studied through photographic observation. Effect of angle of inclination and heat flux values on the operating and melting time has been reported. It has been observed that the operating time is relatively not dependent on the angle of inclination for the unfinned heat sink without PCM and three finned heat sink filled with PCM. The increase in operating time with the decrease in inclination angle from 90o to 0o is found to be 66%, 45% and 43% for PCM based unfinned, one finned and two finned heat sinks, respectively at set point temperature (SPT) = 75 °C and a heat flux of 2.0 kW/m2. Also, the melting time is found to decreases by 44% for unfinned heat sink and 30% for finned heat sinks with the reduction in inclination angle from 90o to 0o.

Rainfall induced landslide susceptibility mapping using novel hybrid soft computing methods based on multi-layer perceptron neural network classifier

Abstract: In this study, we have investigated rainfall induced landslide susceptibility of the Uttarkashi district of India through the developmentof different novel GIS based soft computing approaches namel...

Uncovering randomness and success in society.

Abstract: An understanding of how individuals shape and impact the evolution of society is vastly limited due to the unavailability of large-scale reliable datasets that can simultaneously capture information regarding individual movements and social interactions. We believe that the popular Indian film industry, “Bollywood”, can provide a social network apt for such a study. Bollywood provides massive amounts of real, unbiased data that spans more than 100 years, and hence this network has been used as a model for the present paper. The nodes which maintain a moderate degree or widely cooperate with the other nodes of the network tend to be more fit (measured as the success of the node in the industry) in comparison to the other nodes. The analysis carried forth in the current work, using a conjoined framework of complex network theory and random matrix theory, aims to quantify the elements that determine the fitness of an individual node and the factors that contribute to the robustness of a network. The authors of this paper believe that the method of study used in the current paper can be extended to study various other industries and organizations.

Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets.

Abstract: G-quadruplex structure forming motifs are among the most studied evolutionarily conserved drug targets that are present throughout the genome of different organisms and susceptible to influencing various biological processes. Here we report highly conserved potential G-quadruplex motifs (PGQs) in three essential genes (espK, espB, and cyp51) among 160 strains of the Mycobacterium tuberculosis genome. Products of these genes are involved in pathways that are responsible for virulence determination of bacteria inside the host cell and its survival by maintaining membrane fluidity. The espK and espB genes are essential players that prevent the formation of mature phagolysosome and antigen presentation by host macrophages. The cyp51 is another PGQ-possessing gene involved in sterol biosynthesis pathway and membrane formation. In the present study, we revealed the formation of stable intramolecular parallel G-quadruplex structures by Mycobacterium PGQs using a combination of techniques (NMR, circular dichroism [CD], and gel electrophoresis). Next, isothermal titration calorimetry (ITC) and CD melting analysis demonstrated that a well-known G-quadruplex ligand, TMPyP4, binds to and stabilizes these PGQ motifs. Finally, polymerase inhibition and qRT-PCR assays highlight the biological relevance of PGQ-possessing genes in this pathogen and demonstrate that G-quadruplexes are potential drug targets for the development of effective anti-tuberculosis therapeutics.