Indian Institute of Technology Indore

About: Indian Institute of Technology Indore is a education organization based out in Indore, Madhya Pradesh, India. It is known for research contribution in the topics: Fading & Support vector machine. The organization has 1606 authors who have published 4803 publications receiving 66500 citations.

Fresh, Strength, Durability and Microstructural Properties of Shredded Waste Plastic Concrete

Abstract: The accumulation of waste plastic worldwide creates serious environmental concerns. In the present study, efforts were made to utilize shredded plastic bags as concrete additive materials. Therefore, the workability, density, compressive and flexural strength, water permeability, static and dynamic modulus of elasticity and abrasion resistance properties of concrete were investigated in this study by adding different percentages (0, 0.5, 1, 2, 3 and 5%) of waste plastic bags by weight of concrete. The addition of waste plastic bags decreased the flow ability of fresh concrete and also resulted in loss of hardened concrete properties. The waste plastic concrete samples showed an improved resistance against the abrasion behavior. Microstructure study was also conducted using the optical microscope. The overall results indicated that the waste plastic concrete can be used for non-structural works.

Utilization of shredded waste plastic bags to improve impact and abrasion resistance of concrete

Abstract: Plastic bags (PB) have become a requisite part of human beings in the present time. Hundreds of varieties of plastic bags are used for packing and protecting general things. The disposal of PB is a prime environmental problem which significantly threatens the environment, as its disposal affects fertility of land due to its non-biodegradable nature; it lowers useful land area and generates toxic gases on incineration. Hence, there is a requirement of useful applications for these increased quantities of wastes. The usage of waste plastic bags (WPB) in concrete not only solve dumping crisis of WPB but also yields cost-effective concrete, which is worthy to both plastic recycling and construction industry. In this study, the influence of shredded WPB as fine aggregate on the properties of concrete was evaluated. The replacement of WPB was maintained at 0, 5, 10, 15 and 20% by weight of fine aggregate. The finding of the tested samples showed that the workability, density, compressive strength, flexural strength, static and dynamic modulus of elasticity of concrete samples decreased with increase in the WPB content, while penetrability to water increased. Microstructural analysis of the plastic waste concrete (PWC) specimens was carried out using scanning electron microscope. The microstructural studies indicated the presence of voids and openings between mortar matrix and WPB which was the main reason for the inferior properties of PWC. However, there has been a significant improvement in abrasion resistance, impact resistance and energy absorption capacity of PWC.

Myricetin Reduces Toxic Level of CAG Repeats RNA in Huntington’s Disease (HD) and Spino Cerebellar Ataxia (SCAs)

Abstract: Huntington’s disease (HD) is a neurodegenerative disorder that is caused by abnormal expansion of CAG repeats in the HTT gene. The transcribed mutant RNA contains expanded CAG repeats that translate into a mutant huntingtin protein. This expanded CAG repeat also causes mis-splicing of pre-mRNA due to sequestration of muscle blind like-1 splicing factor (MBNL1), and thus both of these elicit the pathogenesis of HD. Targeting the onset as well as progression of HD by small molecules could be a potent therapeutic approach. We have screened a set of small molecules to target this transcript and found Myricetin, a flavonoid, as a lead molecule that interacts with the CAG motif and thus prevents the translation of mutant huntingtin protein as well as sequestration of MBNL1. Here, we report the first solution structure of the complex formed between Myricetin and RNA containing the 5′CAG/3′GAC motif. Myricetin interacts with this RNA via base stacking at the AA mismatch. Moreover, Myricetin was also found reducin...