Indian Institute of Technology Indore

About: Indian Institute of Technology Indore is a education organization based out in Indore, Madhya Pradesh, India. It is known for research contribution in the topics: Computer science & Chemistry. The organization has 1606 authors who have published 4803 publications receiving 66500 citations.

Stimuli responsive AIE active positional isomers of phenanthroimidazole as non-doped emitters in OLEDs

Abstract: The development of mechanochromic materials by incorporating aggregation induced emission (AIE) luminogens has gained momentum owing to their wide range of applications in optoelectronics In this work, the authors contribute to the development of AIE active mechanochromic phenanthroimidazole derivatives The positional isomers of phenanthroimidazoles 1 and 2 were designed to study the effect of the position of triphenylamine (TPA) and tetraphenylethylene (TPE) units on their AIE and mechanochromism Phenanthroimidazoles 1 and 2 were synthesized using the Suzuki cross-coupling reaction of TPE boronate ester with iodo-phenanthroimidazole of TPA and bromo-phenanthroimidazole of TPA, respectively The single crystal X-ray analysis of 1 reveals a propeller orientation of multiple phenyl rings of the TPA and TPE units, confirming strong AIE characteristics of 1 and 2 Phenanthroimidazoles 1 and 2 exhibit reversible mechanochromism between blue and green colours, which was studied using powder X-ray diffraction (PXRD) The PXRD studies suggest that a phase transition from a crystalline state to an amorphous state is associated with the colour change Moreover, phenanthroimidazoles 1 and 2 worked efficiently as non-doped emitters based on the AIE character and provided a high external quantum efficiency of 28 and 40%, respectively

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature.

Abstract: Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that results in thousands of deaths each year, mostly in African children. The in vivo mechanisms underlying this fatal condition are not entirely understood. Using the animal model of experimental cerebral malaria (ECM), we sought mechanistic insights into the pathogenesis of CM. Fatal disease was associated with alterations in tight junction proteins, vascular breakdown in the meninges / parenchyma, edema, and ultimately neuronal cell death in the brainstem, which is consistent with cerebral herniation as a cause of death. At the peak of ECM, we revealed using intravital two-photon microscopy that myelomonocytic cells and parasite-specific CD8+ T cells associated primarily with the luminal surface of CNS blood vessels. Myelomonocytic cells participated in the removal of parasitized red blood cells (pRBCs) from cerebral blood vessels, but were not required for the disease. Interestingly, the majority of disease-inducing parasite-specific CD8+ T cells interacted with the lumen of brain vascular endothelial cells (ECs), where they were observed surveying, dividing, and arresting in a cognate peptide-MHC I dependent manner. These activities were critically dependent on IFN-γ, which was responsible for activating cerebrovascular ECs to upregulate adhesion and antigen-presenting molecules. Importantly, parasite-specific CD8+ T cell interactions with cerebral vessels were impaired in chimeric mice rendered unable to present EC antigens on MHC I, and these mice were in turn resistant to fatal brainstem pathology. Moreover, anti-adhesion molecule (LFA-1 / VLA-4) therapy prevented fatal disease by rapidly displacing luminal CD8+ T cells from cerebrovascular ECs without affecting extravascular T cells. These in vivo data demonstrate that parasite-specific CD8+ T cell-induced fatal vascular breakdown and subsequent neuronal death during ECM is associated with luminal, antigen-dependent interactions with cerebrovasculature.

Sonication induced peptide-appended bolaamphiphile hydrogels for in situ generation and catalytic activity of Pt nanoparticles

Abstract: The self-assembly of peptide based bolaamphiphiles is investigated upon sonication. We show the ability of peptide bolaamphiphiles 1 and 2 to form strong and rigid self-supporting hydrogels under physiological conditions upon sonication. The self-assembly of higher order supramolecular structures occurs through a synergic effect of hydrogen bonding and π-stacking interactions. Phenylalanine rich peptide bolaamphiphile 2 self-assembles into well-defined nanoribbons whereas tyrosine rich functional material 1 self-assembles into nanofibrillar structures that can be used as a template for in situ generation of platinum nanoparticles. Furthermore, hydrogenation reactions are catalyzed by in situ synthesized Pt nanoparticles such as p-phenylenediamine, which is prepared by the reaction of p-nitroaniline with Pt nanoparticles.