Showing papers by "Indiana University published in 2000"
TL;DR: The rapid growth of research on organizational citizenship behaviors (OCBs) has resulted in some conceptual confusion about the nature of the construct, and made it difficult for all but the most avid readers to keep up with developments in this domain this paper.
5,183 citations
TL;DR: It is concluded that QUICKI is an index of insulin sensitivity obtained from a fasting blood sample that may be useful for clinical research.
Abstract: Insulin resistance plays an important role in the pathophysiology of diabetes and is associated with obesity and other cardiovascular risk factors. The “gold standard” glucose clamp and minimal model analysis are two established methods for determining insulin sensitivity in vivo, but neither is easily implemented in large studies. Thus, it is of interest to develop a simple, accurate method for assessing insulin sensitivity that is useful for clinical investigations. We performed both hyperinsulinemic isoglycemic glucose clamp and insulin-modified frequently sampled iv glucose tolerance tests on 28 non-obese, 13 obese, and 15 type 2 diabetic subjects. We obtained correlations between indexes of insulin sensitivity from glucose clamp studies (SIClamp) and minimal model analysis (SIMM) that were comparable to previous reports (r = 0.57). We performed a sensitivity analysis on our data and discovered that physiological steady state values [i.e. fasting insulin (I0) and glucose (G0)] contain critical informa...
3,598 citations
TL;DR: The Logic of Collective Action (LCA) as mentioned in this paper was a seminal work in modern democratic thought that challenged the assumption that groups would tend to form and take collective action in democratic societies.
Abstract: With the publication of The Logic of Collective Action in 1965, Mancur Olson challenged a cherished foundation of modern democratic thought that groups would tend to form and take collective action...
3,231 citations
TL;DR: Protein kinases that phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) are activated in stressed cells and negatively regulate protein synthesis, resulting in the induction of the downstream gene CHOP (GADD153).
2,988 citations
TL;DR: Among the many traditions of research on "identity", two somewhat different yet strongly related strands of identity theory have developed as mentioned in this paper, reflected in the linkages of social structures with identities.
Abstract: Among the many traditions of research on "identity," two somewhat different yet strongly related strands of identity theory have developed. The first, reflected in the work of Stryker and colleagues, focuses on the linkages of social structures with identities. The second, reflected in the work of Burke and colleagues, focuses on the internal process of self-verification. In the present paper we review each of these strands and then discuss ways in which the two relate to and complement one another Each provides a context for the other: the relation of social structures to identities influences the process of self-verification, while the process of self-verification creates and sustains social structures. The paper concludes with examples of potentially useful applications of identity theory to other arenas of social psychology, and with a discussion of challenges that identity theory must meet to provide a clear understanding of the relation between self and society. The language of "identity" is ubiquitous in contemporary social science, cutting across psychoanalysis, psychology, political science, sociology, and history. The common usage of the term identity, however, belies the considerable variability in both its conceptual meanings and its theoretical role. Even when consideration is restricted to sociology and social psychology, variation is still considerable.'
2,982 citations
TL;DR: Reflecting the internationalization of the marketplace and the increasing prominence of entrepreneurial firms in the global economy, the research paths of international business and entrepreneur-shi... as mentioned in this paper ].
Abstract: Reflecting the internationalization of the marketplace and the increasing prominence of entrepreneurial firms in the global economy, the research paths of international business and entrepreneurshi...
1,667 citations
TL;DR: An information-processing model that is directly applicable to the investigation of how mediated messages are processed is applied to the case of television viewing to demonstrate its applicability and provides a measure for each part of the model.
Abstract: This paper presents an information-processing model that is directly applicable to the investigation of how mediated messages are processed. It applies the model to the case of television viewing to demonstrate its applicability. It provides a measure for each part of the model. It presents evidence that supports the model in the television-viewing situation. Finally, it demonstrates how the model may be used to further research and understanding in well-known theoretical traditions. This model is not meant to stand in opposition to any of these theories but, rather, should work well with them by providing hypothesized mechanisms that may underlie well-known effects. This model should prove useful both to researchers and, eventually, to message producers. To the extent that we can better understand how the content and structure of messages interact with a viewer's information-processing system to determine which parts and how much of a communication message is remembered, we will make great strides in understanding how people communicate.
1,630 citations
TL;DR: A positional cloning approach was used to identify the ADHR gene which included the annotation of 37 genes within 4 Mb of genomic sequence, and missense mutations in a gene encoding a new member of the fibroblast growth factor (FGF) family, FGF23 were identified.
Abstract: Proper serum phosphate concentrations are maintained by a complex and poorly understood process. Identification of genes responsible for inherited disorders involving disturbances in phosphate homeostasis may provide insight into the pathways that regulate phosphate balance. Several hereditary disorders of isolated phosphate wasting have been described, including X-linked hypophosphataemic rickets1 (XLH), hypophosphataemic bone disease2 (HBD), hereditary hypophosphataemic rickets with hypercalciuria3 (HHRH) and autosomal dominant hypophosphataemic rickets4,5 (ADHR). Inactivating mutations of the gene PHEX, encoding a member of the neutral endopeptidase family of proteins, are responsible for XLH (refs 6,7). ADHR (MIM 193100) is characterized by low serum phosphorus concentrations, rickets, osteomalacia, lower extremity deformities, short stature, bone pain and dental abscesses4,5. Here we describe a positional cloning approach used to identify the ADHR gene which included the annotation of 37 genes within 4 Mb of genomic sequence. We identified missense mutations in a gene encoding a new member of the fibroblast growth factor (FGF) family, FGF23. These mutations in patients with ADHR represent the first mutations found in a human FGF gene.
1,429 citations
TL;DR: In this article, a curvilinear relationship between team heterogeneity on nationality and effective performance was investigated through a qualitative field study, with homogeneous and highly heterogeneous teams outperforming moderately heterogeneous ones in the long run.
Abstract: Focusing on hybrid team culture within transnational teams as a facilitator of group interaction, we hypothesized a curvilinear relationship between team heterogeneity on nationality and effective performance. Through a qualitative field study, we developed a mediation model of the effects of transnational team dynamics. Two confirmatory laboratory studies followed. The hypothesized curvilinear relationship was confirmed, with homogeneous and highly heterogeneous teams outperforming moderately heterogeneous ones in the long run. Drawing from conceptual work on status hierarchies, group “faultlines,” and group membership, we discuss implications for team structures in transnational settings.
1,285 citations
TL;DR: Clays have been and continue to be one of the more important industrial minerals and are widely utilized in many facets of our society as mentioned in this paper.Clays and clay minerals are used in geology, agriculture, construction, engineering, process industries, and environmental applications.
1,223 citations
TL;DR: In the presence of heteroscedasticity, ordinary least squares (OLS) estimates are unbiased, but the usual tests of significance are generally inappropriate and their use can lead to incorrect inferences.
Abstract: In the presence of heteroscedasticity, ordinary least squares (OLS) estimates are unbiased, but the usual tests of significance are generally inappropriate and their use can lead to incorrect inferences. Tests based on a heteroscedasticity consistent covariance matrix (HCCM), however, are consistent even in the presence of heteroscedasticity of an unknown form. Most applications that use a HCCM appear to rely on the asymptotic version known as HC0. Our Monte Carlo simulations show that HC0 often results in incorrect inferences when N ≤ 250, while three relatively unknown, small sample versions of the HCCM, and especially a version known as HC3, work well even for N's as small as 25. We recommend that: (1) data analysts should correct for heteroscedasticity using a HCCM whenever there is reason to suspect heteroscedasticity; (2) the decision to use HCCM-based tests should not be determined by a screening test for heteroscedasticity; and (3) when N ≤ 250, the HCCM known as HC3 should be used. Since...
TL;DR: In this article, the authors conceptualize and empirically examine professional associations' relationship-building efforts (core services performance, rewards for contributions, dissemination of organizational knowledge, member interdependence enhancement activities, and reliance on external membership requirements) that are theorized to enhance their membership's commitment to the relationship as well as the membership's relationship behaviors.
Abstract: The authors conceptualize and empirically examine professional associations’ relationship-building efforts (core services performance, rewards for contributions, dissemination of organizational knowledge, member interdependence enhancement activities, and reliance on external membership requirements) that are theorized to enhance their membership’s commitment to the relationship as well as the membership’s relationship behaviors. Three components of commitment—affective, continuance, and normative—are theorized to mediate differentially the correlation between the associations’ relationship-building efforts and their members’ relationship behaviors (membership retention, exchange-based participation, and cooperatively based coproduction). Confirmatory factor analysis validates the commitment measures, and structural equations analysis indicates that normative and affective commitment partially mediate the effects of selected relationship-building efforts on coproduction and member participation. ...
TL;DR: Asymptomatic persons 50 years of age or older who have polyps in the distal colon are more likely to have advanced proximal neoplasia than are persons without distal polyps, and older age and male sex were associated with an increased risk.
Abstract: Background and Methods The clinical significance of a distal colorectal polyp is uncertain. We determined the risk of advanced proximal neoplasia, defined as a polyp with villous features, a polyp with high-grade dysplasia, or cancer, among persons with distal hyperplastic or neoplastic polyps as compared with the risk among persons with no distal polyps. We analyzed data from 1994 consecutive asymptomatic adults (age, 50 years or older) who underwent colonoscopic screening for the first time between September 1995 and December 1998 as part of a program sponsored by an employer. The location and histologic features of all polyps were recorded. Colonoscopy to the level of the cecum was completed in 97.0 percent of the patients. Results Sixty-one patients (3.1 percent) had advanced lesions in the distal colon, including 5 with cancer, and 50 (2.5 percent) had advanced proximal lesions, including 7 with cancer. Twenty-three patients with advanced proximal neoplasms (46 percent) had no distal polyps. The prev...
TL;DR: A 5-year, double-blind, randomized, placebo-controlled study was conducted to determine whether salmon calcitonin nasal spray reduced the risk of new vertebral fractures in postmenopausal women with osteoporosis.
TL;DR: A recent survey as discussed by the authors presents the fundamentals of scale, examines four general scaling issues typical of social science, and explores how different social science disciplines have used scale in their research, especially as they relate to the human dimensions of global environmental change.
TL;DR: The authors analyzed discussion in an online conferencethat supplemented class discussion using an instructional method called the starter-wrappertechnique within a traditional graduate leveleducational psychology course and found that students were using high level cognitive skills such as inferencing and judgment as well as metacognitive strategies related to reflectingon experience and self-awareness.
Abstract: This study analyzed discussion in an online conferencethat supplemented class discussion using aninstructional method called the starter-wrappertechnique within a traditional graduate leveleducational psychology course. Various quantitativemeasures were recorded to compare instructor andstudent participation rates. In addition, Henri's(1992) model for content analysis of computer-mediatedcommunication was employed to qualitatively analyzethe electronic discourse. Using this model, five keyvariables were examined: (1) student participationrates; (2) electronic interaction patterns; (3) socialcues within student messages; (4) cognitive andmetacognitive components of student messages; and (5)depth of processing -- surface or deep -- within messageposting. Transcript content analyses showed that,while students tended to post just the one requiredcomment per week in the conference, their messageswere lengthy, cognitively deep, embedded with peerreferences, and indicative of a student orientedenvironment. Moreover, students were using high levelcognitive skills such as inferencing and judgment aswell as metacognitive strategies related to reflectingon experience and self-awareness. Weekly conferenceactivity graphs revealed that student electroniccomments became more interactive over time, but werehighly dependent on the directions of discussionstarter. To better understand the impact ofelectronic conferencing discourse, modifications toHenri's model as well as qualitative researchsuggestions were offered.
TL;DR: It is found that extracellular enzyme responses of a forest-floor microbial community to chronically applied aqueous NH4NO3 can explain both increased and decreased litter decomposition rates caused by added N.
Abstract: Some natural ecosystems near industrialized and agricultural areas receive atmospheric nitrogen inputs that are an order of magnitude greater than those presumed for preindustrial times. Because nitrogen (N) often limits microbial growth on dead vegetation, increased N input can be expected to affect the ecosystem process of decomposition. We found that extracellular enzyme responses of a forest-floor microbial community to chronically applied aqueous NH4NO3 can explain both increased and decreased litter decomposition rates caused by added N. Microbes responded to N by increasing cellulase activity in decaying leaf litter of flowering dogwood, red maple, and red oak, but in high-lignin oak litter, the activity of lignin-degrading phenol oxidase declined substantially. We believe this is the first report of reduced ligninolytic enzyme activity caused by chronic N addition in an ecosystem. This result provides evidence that ligninolytic enzyme suppression can be an important mechanism explaining decreased ...
TL;DR: In this article, the relationship between reputation, environmental performance, and financial performance is explored, and the contingencies that impact environmental policy making are discussed, as well as the relationships between reputation and environmental performance.
Abstract: Corporate reputation is an intangible asset that is related to marketing and financial performance. The social, economic, and global environment of the 1990'shas resulted in environmental performance becoming an increasingly important component of a company'sreputation. This paper explores the relationship between reputation, environmental performance, and financial performance, and looks at the contingencies that impact environmental policy making.
TL;DR: This work shows that a soil pathogen leads to patterns of seedling mortality in a temperate tree (Prunus serotina) as predicted by the Janzen–Connell hypothesis, and suggests that similar ecological mechanisms operate in tropical and temperate forests.
Abstract: The Janzen–Connell hypothesis1,2 proposes that host-specific, distance- and/or density-dependent predators and herbivores maintain high tree diversity in tropical forests. Negative feedback between plant and soil communities could be a more effective mechanism promoting species coexistence because soil pathogens can increase rapidly in the presence of their host3, causing conditions unfavourable for local conspecific recruitment4,5,6. Here we show that a soil pathogen leads to patterns of seedling mortality in a temperate tree (Prunus serotina) as predicted by the Janzen–Connell hypothesis. In the field, the mean distance to parent of seedling cohorts shifted away from maternal trees over a period of 3 years. Seedlings were grown in soil collected 0–5 m or 25–30 m from Prunus trees. Sterilization of soil collected beneath trees improved seedling survival relative to unsterilized soil, whereas sterilization of distant soil did not affect survival. Pythium spp., isolated from roots of dying seedlings and used to inoculate healthy seedlings, decreased survival by 65% relative to controls. Our results provide the most complete evidence that native pathogens influence tree distributions, as predicted by the Janzen–Connell hypothesis, and suggest that similar ecological mechanisms operate in tropical and temperate forests.
TL;DR: A comparison of the effects of the stigma associated with HIV/AIDS and cancer on self-esteem, body image, and personal control and points to the dimensionality of stigma and its differential negative impact on particular elements of the self, regardless of illness type.
Abstract: Does the impact of stigma on the self differ by illness type? This study focuses on a comparison of the effects of the stigma associated with HIV/AIDS and cancer on self-esteem, body image, and personal control. We test the hypothesis that individuals' perceptions of stigma account for significant differences in the impact of an illness on the self. We examine four dimensions of perceived stigma: social rejection, internalized shame, social isolation, and financial insecurity. In turn, we consider how these dimensions medicate the effects of HIV/AIDS and cancer. Our sample includes 130 persons with HIV/AIDS and 76 persons with cancer. We control for illness severity by including a measure of functional health status that is based on participants' subjective perspectives of the severity of their symptomatology. Our findings provide additional support for modified labeling theory; however, our findings also point to the dimensionality of stigma and its differential negative impact on particular elements of the self, regardless of illness type.
TL;DR: The psychometric properties of the Multidimensional Scale of Perceived Social Support were investigated in 222 urban, largely African-American adolescents, and factor analysis confirmed the three subscale structures of the MSPSS: family, friends, and significant other.
Abstract: The psychometric properties of the Multidimensional Scale of Perceived Social Support (MSPSS) were investigated in 222 urban, largely African-American adolescents (68%). High internal consistency was demonstrated, and factor analysis confirmed the three subscale structures of the MSPSS: family, friends, and significant other. Correlations with a family caring scale supported the discriminant validity of the Family subscale. These results confirm the reliability, validity, and utility of the MSPSS with an urban, largely African-American adolescent sample. Implications of the findings are discussed.
TL;DR: For the first-line treatment of NSCLC, the regimen of gemcitabine plus cisplatin is superior to cis platin alone in terms of response rate, time to disease progression, and overall survival.
Abstract: PURPOSE: The Hoosier Oncology Group has previously reported the results of its phase II trial of the combination of cisplatin plus gemcitabine. In that study of 27 assessable patients with advanced or metastatic non–small-cell lung cancer (NSCLC), the response rate was 33%, with a median survival of 8.4 months. Based on such favorable results, the Hoosier Oncology Group designed this randomized phase III study of gemcitabine plus cisplatin compared with cisplatin alone in chemotherapy-naive patients with advanced NSCLC. PATIENTS AND METHODS: Patients were randomized to receive either cisplatin (100 mg/m2 intravenously on day 1 of a 28-day cycle) or the combination of cisplatin (100 mg/m2 intravenously on day 1) plus gemcitabine (1,000 mg/m2 administered intravenously on days 1, 8, and 15 of a 28-day cycle). RESULTS: From August 1995 to February 1997, 522 assessable chemotherapy-naive patients were randomized. Toxicity was predominantly hematologic and was more pronounced in the combination arm, with grade...
TL;DR: Results suggest that activation of DCs induces the production of functional IDO, which causes depletion of tryptophan and subsequent inhibition of T cell proliferation, which may represent a potential mechanism for DCs to regulate the immune response.
Abstract: Dendritic cells (DCs) play a key role in the activation and regulation of B and T lymphocytes. Production of indoleamine 2, 3-dioxygenase (IDO) by macrophages has recently been described to result in inhibition of T cell proliferation through tryptophan degradation. Since DCs can be derived from monocytes, we sought to determine whether DCs could produce IDO which could potentially regulate T cell proliferation. Northern blot analysis of RNA from cultured monocyte-derived human DC revealed that IDO mRNA was induced upon activation with CD40 ligand and IFN-gamma. IDO produced from activated DCs was functionally active and capable of metabolizing tryptophan to kynurenine. Activated T cells were also capable of inducing IDO production by DCs, which was inhibited by a neutralizing Ab against IFN-gamma. DC production of IDO resulted in inhibition of T cell proliferation, which could be prevented using the IDO inhibitor 1-methyl-dl -tryptophan. These results suggest that activation of DCs induces the production of functional IDO, which causes depletion of tryptophan and subsequent inhibition of T cell proliferation. This may represent a potential mechanism for DCs to regulate the immune response.
TL;DR: In this article, the authors explain how and why the developed countries are undergoing a fundamental shift away from a managed economy and towards an entrepreneurial economy and why this shift is shaping the development of western capitalism and has triggered a shift in government policies away from constraining the freedom of business to contract through regulation, public ownership and antitrust towards a new set of enabling policies which foster the creation and commercialization of new knowledge.
Abstract: This paper explains how and why the developed countries are undergoing a fundamental shift away from a managed economy and towards an entrepreneurial economy. This shift is shaping the development of western capitalism and has triggered a shift in government policies away from constraining the freedom of business to contract through regulation, public ownership and antitrust towards a new set of enabling policies which foster the creation and commercialization of new knowledge. The empirical evidence from a cross-section of countries over time suggests that those countries that have experienced a greater shift from the managed to the entrepreneurial economy have had lower levels of unemployment.
TL;DR: In this paper, the authors tested the predictions of temporal construal theory and time-discounting theories regarding evaluation of near future and distant future options (outcomes, activities, products).
Abstract: Five studies tested the predictions of temporal construal theory and time-discounting theories regarding evaluation of near future and distant future options (outcomes, activities, products). The options had abstract or goal-relevant features (called high-level construal features) as well as more concrete or goal-irrelevant features (called low-level construal features). The studies varied the valence (positive vs. negative) and the type of valence (affective vs. cognitive) of the low-level and high-level construal features. The results show that the weight of high-level construal features, compared with the weight of low-level construal features, is greater in determining distant future preferences than near future preferences. The implications of the results for extant theories of time-dependent changes in preference are discussed.
01 Jan 2000
TL;DR: This paper proposes that the distinguishing characteristic of Aspect-Oriented Programming (AOP) systems is that they allow programming by making quantified programmatic assertions over programs written by programmers oblivious to such assertions.
Abstract: This paper proposes that the distinguishing characteristic of Aspect-Oriented Programming (AOP) systems is that they allow programming by making quantified programmatic assertions over programs written by programmers oblivious to such assertions. Thus, AOP systems can be analyzed with respect to three critical dimensions: the kinds of quantifications allowed, the nature of the actions that can be asserted, and the mechanism for combining base-level actions with asserted actions. Consequences of this perspective are the recognition that certain systems are not AOP and that some mechanisms are expressive enough to allow programming an AOP system within them. A corollary is that while AOP can be applied to Object-Oriented Programming, it is an independent concept applicable to other programming styles.
TL;DR: In this article, the authors examined how the risks of accelerated internationalization of businesses can be mitigated and how the internationalization will accelerate in the 21st century, using the Organisation for Economic Co-operation and Development (OECD).
Abstract: The Organisation for Economic Co-operation and Development predicts that the internationalization of businesses will accelerate in the 21st century. Our study examined how the risks of accelerated ...
TL;DR: In this paper, three different conceptual models (experience with police, quality of life, and neighborhood context) were tested for directional accuracy and ability to explain satisfaction with the police.
Abstract: We test three different conceptual models—“experience with police,” “quality of life,” and “neighborhood context”—for directional accuracy and ability to explain satisfaction with the police. We also investigate whether these models help to explain the common finding that African-Americans are more dissatisfied with the police than are Caucasians. To do so, we use hierarchical linear modeling to simultaneously regress our outcome measure on clusters of citizen- and neighborhood-level variables. The analysis was conducted using recently collected information from the Project on Policing Neighborhoods (POPN). The data file consisted of survey responses from 5,361 citizens residing in 58 neighborhoods located in Indianapolis, Indiana and St. Petersburg, Florida. At the citizen level, the psychologically based “quality of life” model accounts for the greatest proportion of explained variance and provides the greatest directional accuracy. Also, residents of neighborhoods characterized by concentrated disadvan...
TL;DR: In this article, the impact of various top management team characteristics on firm international diversification was investigated using data from 126 firms in the electronics industry, and it was shown that higher average age, higher average tenure and higher average elite education are associated with international expansion.
TL;DR: Thrombotic thrombocytopenic purpura can occur after the initiation of clopidogrel therapy, often within the first two weeks of treatment, and Physicians should be aware of the possibility of this syndrome when initiating clopIDogrel treatment.
Abstract: Background The antiplatelet drug clopidogrel is a new thienopyridine derivative whose mechanism of action and chemical structure are similar to those of ticlopidine. The estimated incidence of ticlopidine-associated thrombotic thrombocytopenic purpura is 1 per 1600 to 5000 patients treated, whereas no clopidogrel-associated cases were observed among 20,000 closely monitored patients treated in phase 3 clinical trials and cohort studies. Because of the association between ticlopidine use and thrombotic thrombocytopenic purpura and other adverse effects, clopidogrel has largely replaced ticlopidine in clinical practice. More than 3 million patients have received clopidogrel. We report the clinical and laboratory findings in 11 patients in whom thrombotic thrombocytopenic purpura developed during or soon after treatment with clopidogrel. Methods The 11 patients were identified by active surveillance by the medical directors of blood banks (3 patients), hematologists (6), and the manufacturer of clopidogrel (2). Results Ten of the 11 patients received clopidogrel for 14 days or less before the onset of thrombotic thrombocytopenic purpura. Although 10 of the 11 patients had a response to plasma exchange, 2 required 20 or more exchanges before clinical improvement occurred, and 2 had relapses while not receiving clopidogrel. One patient died despite undergoing plasma exchange soon after diagnosis. Conclusions Thrombotic thrombocytopenic purpura can occur after the initiation of clopidogrel therapy, often within the first two weeks of treatment. Physicians should be aware of the possibility of this syndrome when initiating clopidogrel treatment.