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Institution

Indiana University

EducationBloomington, Indiana, United States
About: Indiana University is a education organization based out in Bloomington, Indiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 64480 authors who have published 150058 publications receiving 6392902 citations. The organization is also known as: Indiana University system & indiana.edu.


Papers
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Journal ArticleDOI
TL;DR: In this article, the authors found that the uptake of triacylglycerol substrates via the scavenger receptor CD36 and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of elevated oxidative phosphorylation, enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together define M2 activation.
Abstract: Alternative (M2) activation of macrophages driven via the α-chain of the receptor for interleukin 4 (IL-4Rα) is important for immunity to parasites, wound healing, the prevention of atherosclerosis and metabolic homeostasis M2 polarization is dependent on fatty acid oxidation (FAO), but the source of the fatty acids that support this metabolic program has not been clear We found that the uptake of triacylglycerol substrates via the scavenger receptor CD36 and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of elevated oxidative phosphorylation, enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together define M2 activation Inhibition of lipolysis suppressed M2 activation during infection with a parasitic helminth and blocked protective responses to this pathogen Our findings delineate a critical role for cell-intrinsic lysosomal lipolysis in M2 activation

762 citations

Journal ArticleDOI
TL;DR: It is concluded that species introductions generally alter plants' interactions with enemies, mutualists and competitors, and that there is increasing evidence that these altered interactions jointly influence the success of introduced populations.
Abstract: Introduced plant populations lose interactions with enemies, mutualists and competitors from their native ranges, and gain interactions with new species, under new abiotic conditions. From a biogeographical perspective, differences in the assemblage of interacting species, as well as in abiotic conditions, may explain the demographic success of the introduced plant populations relative to conspecifics in their native range. Within invaded communities, the new interactions and conditions experienced by the invader may influence both its demographic success and its effects on native biodiversity. Here, we examine indirect effects involving enemies, mutualists and competitors of introduced plants, and effects of abiotic conditions on biotic interactions. We then synthesize ideas building on Darwin’s idea that the kinds of new interactions gained by an introduced population will depend on its relatedness to native populations. This yields a heuristic framework to explain how biotic interactions and abiotic conditions influence invader success. We conclude that species introductions generally alter plants interactions with enemies, mutualists and competitors, and that there is increasing evidence that these altered interactions jointly influence the success of introduced populations. Ecology Letters (2006) 9: 726‐740

761 citations

Journal ArticleDOI
TL;DR: This article examined the effects of student-faculty interaction on student satisfaction and on a range of self-reported learning and personal development gains associated with attending college of 5,409 full-time undergraduates from 126 four-year colleges and universities.
Abstract: This study examined the effects of student-faculty interaction on student satisfaction and on a range of self-reported learning and personal development gains associated with attending college of 5,409 full-time undergraduates from 126 four-year colleges and universities. Findings show that the frequency of student-faculty interaction increased from first year through the senior year. Although its net effects were trivial, such interactions had substantial positive effects on studentsO efforts in other educationally purposeful activities, which had non-trivial effects on their estimated gains and satisfaction.

759 citations

Journal ArticleDOI
TL;DR: Having a sense of ethnic pride, involvement in ethinic practices, and cultural commitment to one's racial/ethnic group may protect mental health, and the strength of identification with an ethnic group is found to be directly associated with fewer depressive symptoms.
Abstract: Using data (N = 2,109) from a large-scale epidemiological study of Filipino Americans, this study examines whether ethnic identity is linked to mental health and reduces the stress of discrimination. The strength of identification with an ethnic group is found to be directly associated with fewer depressive symptoms. In other words, having a sense of ethnic pride, involvement in ethinic practices, and cultural commitment to one's racial/ethnic group may protect mental health. Self-reports of racial/ethnic discrimination over a lifetime and everyday discrimination in the past month not due to race/ethnicity are associated with increased levels of depressive symptoms. Yet ethnic identity buffers the stress of racial/ethnic discrimination. This suggests that ethnic identity is a coping resource for racial/ethnic minorities that should not be overlooked. The strong link between ethnic identity and better mental health has implications for social-psychological theories on race/ethnicity and assimilation in the United States.

757 citations

Journal ArticleDOI
TL;DR: In this paper, the authors use mental models of markets to simplify and impose order on complex and ambiguous competitive environments and isolate points of competitive advantage or deficiency, and present a study of seni...
Abstract: Managers use mental models of markets to simplify and impose order on complex and ambiguous competitive environments and isolate points of competitive advantage or deficiency. In this study of seni...

755 citations


Authors

Showing all 64884 results

NameH-indexPapersCitations
Frank B. Hu2501675253464
Stuart H. Orkin186715112182
Bruce M. Spiegelman179434158009
David R. Williams1782034138789
D. M. Strom1763167194314
Markus Antonietti1761068127235
Lei Jiang1702244135205
Brenda W.J.H. Penninx1701139119082
Nahum Sonenberg167647104053
Carl W. Cotman165809105323
Yang Yang1642704144071
Jaakko Kaprio1631532126320
Ralph A. DeFronzo160759132993
Gavin Davies1592036149835
Tyler Jacks158463115172
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023127
2022694
20217,272
20207,310
20196,943
20186,496