Institution
Indiana University
Education•Bloomington, Indiana, United States•
About: Indiana University is a education organization based out in Bloomington, Indiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 64480 authors who have published 150058 publications receiving 6392902 citations. The organization is also known as: Indiana University system & indiana.edu.
Topics: Population, Poison control, Health care, Transplantation, Cancer
Papers published on a yearly basis
Papers
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TL;DR: It is shown that lysophosphatidic acid levels increase in bronchoalveolar lavage fluid following lung injury in the bleomycin model of pulmonary fibrosis, and that mice lacking one of its receptors, LPA1, are markedly protected from fibrosis and mortality in this model.
Abstract: Aberrant wound-healing responses to injury have been implicated in the development of pulmonary fibrosis, but the mediators directing these pathologic responses have yet to be fully identified. We show that lysophosphatidic acid levels increase in bronchoalveolar lavage fluid following lung injury in the bleomycin model of pulmonary fibrosis, and that mice lacking one of its receptors, LPA1, are markedly protected from fibrosis and mortality in this model. The absence of LPA1 led to reduced fibroblast recruitment and vascular leak, two responses that may be excessive when injury leads to fibrosis rather than to repair, whereas leukocyte recruitment was preserved during the first week after injury. In persons with idiopathic pulmonary fibrosis, lysophosphatidic acid levels in bronchoalveolar lavage fluid were also increased, and inhibition of LPA1 markedly reduced fibroblast responses to the chemotactic activity of this fluid. LPA1 therefore represents a new therapeutic target for diseases in which aberrant responses to injury contribute to fibrosis, such as idiopathic pulmonary fibrosis.
707 citations
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University of California, San Francisco1, Southampton General Hospital2, University of Auckland3, University of Pennsylvania4, University of California, San Diego5, Tufts University6, University of Siena7, Malmö University8, Indiana University9, The Chinese University of Hong Kong10, St. Vincent's Institute of Medical Research11, University of Buenos Aires12, World Health Organization13
TL;DR: Harry K. Genant (Chairman) , Cyrus Cooper (Rapporteur) , Gyula Poor (Rappy) , Ian Reid (R apporteur), George Ehrlich (Editor) and Nikolai Khaltaev (WHO Secretariat) 30
Abstract: Harry K. Genant (Chairman) , Cyrus Cooper (Rapporteur) , Gyula Poor (Rapporteur) , Ian Reid (Rapporteur) , George Ehrlich (Editor), J. Kanis (Editor), B. E. Christopher Nordin (Editor), Elizabet h Barrett-Connor , Dennis Black, J.-P. Bonjour, Bess Dawson-Hughes , Pierre D. Delmas, J. Dequeker , Sergio Ragi Eis, Carlo Gennari , Olaf Johnell , C. Conrad Johnston, Jr, Edith M. C. Lau, Uri A. Liberman, Robert Lindsay, Thomas John Martin, Basel Masri, Carlos A. Mautalen, Pierre J. Meunier, Paul D. Miller , Ambrish Mithal, Hirotoshi Morii , Socrates Papapoul os, Anthony Woolf, Wei Yu and Nikolai Khaltaev (WHO Secretariat) 30
707 citations
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TL;DR: In this article, the authors used field and laboratory measurements, geographic information systems, and simulation modeling to investigate the potential effects of accelerated sea-level rise on tidal marsh area and delivery of ecosystem ser- vices along the Georgia coast.
Abstract: We used field and laboratory measurements, geographic information systems, and simulation modeling to investigate the potential effects of accelerated sea-level rise on tidal marsh area and delivery of ecosystem ser- vices along the Georgia coast. Model simulations using the Intergovernmental Panel on Climate Change (IPCC) mean and maximum estimates of sea-level rise for the year 2100 suggest that salt marshes will decline in area by 20% and 45%, respectively. The area of tidal freshwater marshes will increase by 2% under the IPCC mean scenario, but will decline by 39% under the maximum scenario. Delivery of ecosystem services associated with productivity (macrophyte biomass) and waste treatment (nitrogen accumulation in soil, potential denitrification) will also decline. Our findings suggest that tidal marshes at the lower and upper salinity ranges, and their attendant delivery of ecosystem services, will be most affected by accelerated sea- level rise, unless geomorphic conditions (ie gradual increase in elevation) enable tidal freshwater marshes to migrate inland, or vertical accretion of salt marshes to increase, to compensate for accelerated sea-level rise.
706 citations
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TL;DR: The incidence rate of ARF in Medicare beneficiaries has been increasing and those of older age, male gender, and black race are more likely to have ARF, which is a major contributor to morbidity and mortality in hospitalized patients.
Abstract: This study's objective was to determine the incidence and mortality of acute renal failure (ARF) in Medicare beneficiaries. Data were from hospitalized Medicare beneficiaries (5,403,015 discharges) between 1992 and 2001 from the 5% sample of Medicare claims. For 1992 to 2001, the overall incidence rate of ARF was 23.8 cases per 1000 discharges, with rates increasing by approximately 11% per year. Older age, male gender, and black race were strongly associated (P < 0.0001) with ARF. The overall in-hospital death rate was 4.6% in discharges without ARF, 15.2% in discharges with ARF coded as the principal diagnosis, and 32.6% in discharges with ARF as a secondary diagnosis. In-hospital death rates were 32.9% in discharges with ARF that required renal dialysis and 27.5% in those with ARF that did not require dialysis. Death within 90 d after hospital admission was 13.1% in discharges without ARF, 34.5% in discharges with ARF coded as the principal diagnosis, and 48.6% in discharges with ARF as a secondary diagnosis. Discharges with ARF were more (P < 0.0001) likely to have intensive care and other acute organ dysfunction than those without ARF. For discharges both with and without ARF, rates for death within 90 d after hospital admission showed a declining trend. In conclusion, the incidence rate of ARF in Medicare beneficiaries has been increasing. Those of older age, male gender, and black race are more likely to have ARF. These data show ARF to be a major contributor to morbidity and mortality in hospitalized patients.
706 citations
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TL;DR: In patients with untreated genotype 1 chronic hepatitis C infection, the addition of the direct-acting antiviral agent boceprevir to standard treatment with peginterferon and ribavirin after a 4-week lead-in seems to have the potential to double the sustained response rate compared with that recorded with standard treatment alone.
705 citations
Authors
Showing all 64884 results
Name | H-index | Papers | Citations |
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Frank B. Hu | 250 | 1675 | 253464 |
Stuart H. Orkin | 186 | 715 | 112182 |
Bruce M. Spiegelman | 179 | 434 | 158009 |
David R. Williams | 178 | 2034 | 138789 |
D. M. Strom | 176 | 3167 | 194314 |
Markus Antonietti | 176 | 1068 | 127235 |
Lei Jiang | 170 | 2244 | 135205 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Nahum Sonenberg | 167 | 647 | 104053 |
Carl W. Cotman | 165 | 809 | 105323 |
Yang Yang | 164 | 2704 | 144071 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
Gavin Davies | 159 | 2036 | 149835 |
Tyler Jacks | 158 | 463 | 115172 |