Institution
Indiana University
Education•Bloomington, Indiana, United States•
About: Indiana University is a education organization based out in Bloomington, Indiana, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 64480 authors who have published 150058 publications receiving 6392902 citations. The organization is also known as: Indiana University system & indiana.edu.
Topics: Population, Poison control, Health care, Transplantation, Cancer
Papers published on a yearly basis
Papers
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TL;DR: Langerhans cell precursors initially arise from yolk sac progenitors, but are later superseded by fetal liver monocytes.
Abstract: Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise from hematopoietic precursors that seed the skin before birth. However, the origin of these embryonic precursors remains unclear. Using in vivo lineage tracing, we identify a first wave of yolk sac (YS)–derived primitive myeloid progenitors that seed the skin before the onset of fetal liver hematopoiesis. YS progenitors migrate to the embryo proper, including the prospective skin, where they give rise to LC precursors, and the brain rudiment, where they give rise to microglial cells. However, in contrast to microglia, which remain of YS origin throughout life, YS-derived LC precursors are largely replaced by fetal liver monocytes during late embryogenesis. Consequently, adult LCs derive predominantly from fetal liver monocyte-derived cells with a minor contribution of YS-derived cells. Altogether, we establish that adult LCs have a dual origin, bridging early embryonic and late fetal myeloid development.
659 citations
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Primary Children's Hospital1, University of Colorado Denver2, Northwestern University3, Georgetown University4, University of Washington5, Columbia University6, University of North Carolina at Chapel Hill7, University of California, San Francisco8, Baylor University Medical Center9, Mayo Clinic10, University of California, San Diego11, University of Miami12, Johns Hopkins University13, University of Kansas14, Henry Ford Health System15, Indiana University16, Washington University in St. Louis17, Duke University18, New York University19, University of Michigan20, University of Pennsylvania21, Harvard University22
TL;DR: In this article, the NS5A inhibitor ledipasvir, the nucleotide polymerase inhibitor sofosbuvir, and ribavirin were used to treat chronic hepatitis C virus (HCV) infection in patients with advanced liver disease.
659 citations
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TL;DR: A model of supply chain complexity is put forth and empirically tests it using plant-level data from 209 plants across seven countries and shows that upstream complexity, internal manufacturing complexity, and downstream complexity all have a negative impact on manufacturing plant performance.
659 citations
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TL;DR: In the US, Canada, UK, Germany, France, and Japan, the propensity to pay dividends is higher among larger, more profitable firms, and those for which retained earnings comprise a large fraction of total equity as discussed by the authors.
659 citations
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Katholieke Universiteit Leuven1, Tokai University2, Hennepin County Medical Center3, Veterans Health Administration4, Indiana University5, Great Ormond Street Hospital for Children NHS Foundation Trust6, University of Calgary7, Royal Melbourne Hospital8, VU University Medical Center9, Stanford University10
TL;DR: The KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of CKD-MBD represents a selective update of the prior CKDMBD Guideline published in 2009.
657 citations
Authors
Showing all 64884 results
Name | H-index | Papers | Citations |
---|---|---|---|
Frank B. Hu | 250 | 1675 | 253464 |
Stuart H. Orkin | 186 | 715 | 112182 |
Bruce M. Spiegelman | 179 | 434 | 158009 |
David R. Williams | 178 | 2034 | 138789 |
D. M. Strom | 176 | 3167 | 194314 |
Markus Antonietti | 176 | 1068 | 127235 |
Lei Jiang | 170 | 2244 | 135205 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Nahum Sonenberg | 167 | 647 | 104053 |
Carl W. Cotman | 165 | 809 | 105323 |
Yang Yang | 164 | 2704 | 144071 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
Gavin Davies | 159 | 2036 | 149835 |
Tyler Jacks | 158 | 463 | 115172 |