Indiana University – Purdue University Indianapolis

About: Indiana University – Purdue University Indianapolis is a education organization based out in Indianapolis, Indiana, United States. It is known for research contribution in the topics: Population & Health care. The organization has 18346 authors who have published 31223 publications receiving 1129445 citations.

The PHQ-9: validity of a brief depression severity measure.

Abstract: OBJECTIVE: While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity.

Particle swarm optimization

Abstract: A concept for the optimization of nonlinear functions using particle swarm methodology is introduced The evolution of several paradigms is outlined, and an implementation of one of the paradigms is discussed Benchmark testing of the paradigm is described, and applications, including nonlinear function optimization and neural network training, are proposed The relationships between particle swarm optimization and both artificial life and genetic algorithms are described

A modified particle swarm optimizer

Abstract: Evolutionary computation techniques, genetic algorithms, evolutionary strategies and genetic programming are motivated by the evolution of nature. A population of individuals, which encode the problem solutions are manipulated according to the rule of survival of the fittest through "genetic" operations, such as mutation, crossover and reproduction. A best solution is evolved through the generations. In contrast to evolutionary computation techniques, Eberhart and Kennedy developed a different algorithm through simulating social behavior (R.C. Eberhart et al., 1996; R.C. Eberhart and J. Kennedy, 1996; J. Kennedy and R.C. Eberhart, 1995; J. Kennedy, 1997). As in other algorithms, a population of individuals exists. This algorithm is called particle swarm optimization (PSO) since it resembles a school of flying birds. In a particle swarm optimizer, instead of using genetic operators, these individuals are "evolved" by cooperation and competition among the individuals themselves through generations. Each particle adjusts its flying according to its own flying experience and its companions' flying experience. We introduce a new parameter, called inertia weight, into the original particle swarm optimizer. Simulations have been done to illustrate the significant and effective impact of this new parameter on the particle swarm optimizer.

Comprehensive molecular portraits of human breast tumours

Abstract: We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein arrays. Our ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers; however, there were numerous subtype-associated and novel gene mutations including the enrichment of specific mutations in GATA3, PIK3CA and MAP3K1 with the luminal A subtype. We identified two novel protein-expression-defined subgroups, possibly produced by stromal/microenvironmental elements, and integrated analyses identified specific signalling pathways dominant in each molecular subtype including a HER2/phosphorylated HER2/EGFR/phosphorylated EGFR signature within the HER2-enriched expression subtype. Comparison of basal-like breast tumours with high-grade serous ovarian tumours showed many molecular commonalities, indicating a related aetiology and similar therapeutic opportunities. The biological finding of the four main breast cancer subtypes caused by different subsets of genetic and epigenetic abnormalities raises the hypothesis that much of the clinically observable plasticity and heterogeneity occurs within, and not across, these major biological subtypes of breast cancer.

Acute Kidney Injury Network: Report of an Initiative to Improve Outcomes in Acute Kidney Injury

Abstract: Acute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Having a uniform standard for diagnosing and classifying AKI would enhance our ability to manage these patients. Future clinical and translational research in AKI will require collaborative networks of investigators drawn from various disciplines, dissemination of information via multidisciplinary joint conferences and publications, and improved translation of knowledge from pre-clinical research. We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI. Members representing key societies in critical care and nephrology along with additional experts in adult and pediatric AKI participated in a two day conference in Amsterdam, The Netherlands, in September 2005 and were assigned to one of three workgroups. Each group's discussions formed the basis for draft recommendations that were later refined and improved during discussion with the larger group. Dissenting opinions were also noted. The final draft recommendations were circulated to all participants and subsequently agreed upon as the consensus recommendations for this report. Participating societies endorsed the recommendations and agreed to help disseminate the results. The term AKI is proposed to represent the entire spectrum of acute renal failure. Diagnostic criteria for AKI are proposed based on acute alterations in serum creatinine or urine output. A staging system for AKI which reflects quantitative changes in serum creatinine and urine output has been developed. We describe the formation of a multidisciplinary collaborative network focused on AKI. We have proposed uniform standards for diagnosing and classifying AKI which will need to be validated in future studies. The Acute Kidney Injury Network offers a mechanism for proceeding with efforts to improve patient outcomes.