Institution
Institute for Systems Biology
Nonprofit•Seattle, Washington, United States•
About: Institute for Systems Biology is a nonprofit organization based out in Seattle, Washington, United States. It is known for research contribution in the topics: Population & Proteomics. The organization has 1277 authors who have published 2777 publications receiving 353165 citations.
Topics: Population, Proteomics, Gene, Proteome, Systems biology
Papers published on a yearly basis
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ETH Zurich1, University of Zurich2, Russian Academy3, University of Geneva4, Fred Hutchinson Cancer Research Center5, McGill University6, University of Victoria7, University of Turku8, Boston University9, Institute for Systems Biology10, Northeastern University11, Lund University12, Royan Institute13, National Institutes of Health14, Stanford University15, Royal Institute of Technology16, University of Delaware17, Niigata University18, Yonsei University19, University of Michigan20
TL;DR: The Human Proteome Organization urges each national research funding agency and the scientific community at large to identify their preferred pathways to participate in aspects of this highly promising project in a HPP consortium of funders and investigators.
344 citations
TL;DR: Together, these data identify Spc105 as a key target of the Mps1 kinase and show that the opposing activities of MPS1 and PP1 regulate the kinetochore localization of the Bub1 protein.
344 citations
TL;DR: It is demonstrated that ADAR1 is a specific and essential negative regulator of the MDA5-MAVS RNA sensing pathway and that both of these functions were required throughout life.
342 citations
TL;DR: The data support a general mechanism of transcriptional control through which histone acetylation upstream of gene activation is promoted partially through availability of H3K4me3, "read" by binding modules in select subunits.
337 citations
TL;DR: The identification of a new evolutionarily conserved subunit of TFIIH implicated in TTD-A provides insight intoTFIIH function in transcription, DNA repair and human disease.
Abstract: DNA repair-deficient trichothiodystrophy (TTD) results from mutations in the XPD and XPB subunits of the DNA repair and transcription factor TFIIH. In a third form of DNA repair-deficient TTD, called group A, none of the nine subunits encoding TFIIH carried mutations; instead, the steady-state level of the entire complex was severely reduced. A new, tenth TFIIH subunit (TFB5) was recently identified in yeast. Here, we describe the identification of the human TFB5 ortholog and its association with human TFIIH. Microinjection of cDNA encoding TFB5 (GTF2H5, also called TTDA) corrected the DNA-repair defect of TTD-A cells, and we identified three functional inactivating mutations in this gene in three unrelated families with TTD-A. The GTF2H5 gene product has a role in regulating the level of TFIIH. The identification of a new evolutionarily conserved subunit of TFIIH implicated in TTD-A provides insight into TFIIH function in transcription, DNA repair and human disease.
328 citations
Authors
Showing all 1292 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Younan Xia | 216 | 943 | 175757 |
| Ruedi Aebersold | 182 | 879 | 141881 |
| David Haussler | 172 | 488 | 224960 |
| Steven P. Gygi | 172 | 704 | 129173 |
| Nahum Sonenberg | 167 | 647 | 104053 |
| Leroy Hood | 158 | 853 | 128452 |
| Mark H. Ellisman | 117 | 637 | 55289 |
| Wei Zhang | 112 | 1189 | 93641 |
| John Ralph | 109 | 442 | 39238 |
| Eric H. Davidson | 106 | 454 | 47058 |
| James R. Heath | 103 | 425 | 58548 |
| Alan Aderem | 99 | 246 | 46682 |
| Anne-Claude Gingras | 97 | 336 | 40714 |
| Trey Ideker | 97 | 306 | 72276 |
| Michael H. Gelb | 94 | 506 | 34714 |