Institution
Institute of Business & Medical Careers
About: Institute of Business & Medical Careers is a based out in . It is known for research contribution in the topics: Population & Noxious stimulus. The organization has 646 authors who have published 563 publications receiving 15342 citations.
Topics: Population, Noxious stimulus, Transthyretin, Gene, Cancer
Papers published on a yearly basis
Papers
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TL;DR: Analysis of the circuitry within the RVM reveals that the neural basis for bidirectional control from the midline system is two populations of neurons, ON-cells and OFF-cells, that are differentially recruited by higher structures important in fear, illness and psychological stress to enhance or inhibit pain.
808 citations
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TL;DR: In this paper, the association between angiogenesis and inflammation in pathological situations has been investigated and the interplay between inflammatory cells, endothelial cells, and fibroblasts in chronic inflammation sites, together with the fact that inflammation and angionogenesis can actually be triggered by the same molecular events, further strengthen this association.
Abstract: Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn's disease, diabetes, and cancer. Lately, this concept has further been substantiated by the finding that several previously established non-inflammatory disorders, such as osteoarthritis and obesity, display both inflammation and angiogenesis in an exacerbated manner. In addition, the interplay between inflammatory cells, endothelial cells and fibroblasts in chronic inflammation sites, together with the fact that inflammation and angiogenesis can actually be triggered by the same molecular events, further strengthen this association. Therefore, elucidating the underlying cellular and molecular mechanisms that gather together the two processes is mandatory in order to understand their synergistic effect, and to develop new therapeutic approaches for the management of these disorders that cause a great deal of discomfort, disability, and in some cases death.
421 citations
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Harvard University1, Institute of Business & Medical Careers2, University of British Columbia3, Ulster University4, Hennepin County Medical Center5, Johns Hopkins University6, Autonomous University of Madrid7, University of Calgary8, University of Sydney9, Westmead Hospital10, University of Rome Tor Vergata11, Emory University12, University of Florida13, Boston University14, University of Virginia15, University of California, San Francisco16, University of South Carolina17, Columbia University18, University of Porto19, University of Iowa20, University of Ulm21
TL;DR: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is strongly correlated with an expanded CAG trinucleotide repeat, and the rate of HD pathogenesis leading to motor diagnosis is determined by a completely dominant action of the longest expanded allele and as yet unidentified genetic or environmental factors.
Abstract: Objective: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG repeat allele has been reported also to influence age at onset, in interaction with the expanded allele. Due to profound implications for disease mechanism and modification, we tested whether the normal allele, interaction between the expanded and normal alleles, or presence of a second expanded allele affects age at onset of HD motor signs. Methods: We modeled natural log-transformed age at onset as a function of CAG repeat lengths of expanded and normal alleles and their interaction by linear regression. Results: An apparently significant effect of interaction on age at motor onset among 4,068 subjects was dependent on a single outlier data point. A rigorous statistical analysis with a wellbehaved dataset that conformed to the fundamental assumptions of linear regression (e.g., constant variance and normally distributed error) revealed significance only for the expanded CAG repeat, with no effect of the normal CAG repeat. Ten subjects with 2 expanded alleles showed an age at motor onset consistent with the length of the larger expanded allele. Conclusions: Normal allele CAG length, interaction between expanded and normal alleles, and presence of a second expanded allele do not influence age at onset of motor manifestations, indicating that the rate of HD pathogenesis leading to motor diagnosis is determined by a completely dominant action of the longest expanded allele and as yet unidentified genetic or environmental factors. Neurology ® 2012;78:690–695
303 citations
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TL;DR: The comparison of the prevalence profile of the LSDs presenting a prevalence higher than 0.5/100 000 in the Portuguese, Dutch and Australian populations showed the existence of a higher prevalence of GM2 gangliosidoses (B variant), mucolipidose (II and III), Niemman-Pick type C and metachromatic leukodystrophy (MLD), and a lower prevalence of Pompe and Fabry.
Abstract: Lysosomal storage diseases (LSDs) are a group of inherited metabolic disorders individually considered as rare, and few data on its prevalence has been reported in the literature. The overall birth prevalence of the 29 different LSDs studied in the Portuguese population was calculated to be 25/100000 live births, twice the prevalence previously described in Australia and in The Netherlands. The comparison of the prevalence profile of the LSDs presenting a prevalence higher than 0.5/100000 in the Portuguese, Dutch and Australian populations showed, in the Portuguese, the existence of a higher prevalence of GM2 gangliosidoses (B variant), mucolipidoses (II and III), Niemman-Pick type C and metachromatic leukodystrophy (MLD), and a lower prevalence of Pompe and Fabry. The highest prevalence value for a single LSD is the one of GM2 gangliosidoses (B variant), corresponding to 3/100000, a value which is significantly higher than the prevalence of the most frequent LSD in Dutch, Pompe disease (2/100000) and Australians, Gaucher's disease (GD) (1.8/100000). It is worth noting that the highest prevalence of GM2 gangliosidoses found in the Portuguese is mainly due to the existence of a unique subtype, the rare juvenile B1 variant.
294 citations
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TL;DR: A DNA sequence that confers a response to a class of rodent hepatocarcinogens termed peroxisome proliferators has been identified 2947bp upstream of the rat peroxISomal bifunctional enzyme gene and it is shown that two members of the steroid hormone receptor family co-operate to bind specifically to this sequence.
266 citations
Authors
Showing all 646 results
Name | H-index | Papers | Citations |
---|---|---|---|
Andrew Ivanov | 142 | 1812 | 97390 |
Jacques Neefjes | 95 | 331 | 31500 |
Dino Moras | 93 | 369 | 31080 |
Maria João Saraiva | 68 | 302 | 14775 |
Olivier Poch | 65 | 207 | 16597 |
António Afonso | 61 | 418 | 12936 |
Angel Nadal | 59 | 155 | 13933 |
Robert P. P. Fuchs | 55 | 172 | 9992 |
Jorge Sequeiros | 50 | 254 | 8987 |
Vicente Micol | 50 | 161 | 7145 |
Francisco Cruz | 48 | 248 | 7287 |
Rui Appelberg | 46 | 133 | 6359 |
João F. Passos | 45 | 104 | 9647 |
Antonio Ferrer-Montiel | 45 | 149 | 6029 |
Claudio E. Sunkel | 44 | 110 | 6131 |