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Institution

Institute of Chartered Accountants of Nigeria

About: Institute of Chartered Accountants of Nigeria is a based out in . It is known for research contribution in the topics: Population & Adipose tissue. The organization has 528 authors who have published 579 publications receiving 18688 citations.


Papers
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Journal ArticleDOI
TL;DR: Although early detection and treatment with statins and other LDL-C lowering therapies can improve survival, FH remains widely underdiagnosed and undertreated, thereby representing a major global public health challenge.

123 citations

Journal ArticleDOI
Rany M. Salem1, Jennifer Todd2, Jennifer Todd3, Niina Sandholm4, Joanne B. Cole2, Joanne B. Cole3, Wei-Min Chen5, Darrell Andrews6, Marcus G. Pezzolesi7, Paul M. McKeigue, Linda T. Hiraki, Chengxiang Qiu8, Viji Nair, Chen Di Liao, Jing Jing Cao, Erkka Valo4, Suna Onengut-Gumuscu5, Adam M. Smiles9, Stuart J. McGurnaghan10, Jani K. Haukka4, Valma Harjutsalo, Eoin P. Brennan6, Natalie R. van Zuydam11, Emma Ahlqvist12, Ross Doyle6, Tarunveer S. Ahluwalia13, Maria Lajer13, Maria Hughes6, Jihwan Park8, Jan Skupien9, Athina Spiliopoulou, Andrew C. Liu, Rajasree Menon14, Carine M. Boustany-Kari15, Hyun Min Kang14, Robert G. Nelson16, Ronald Klein17, Barbara E.K. Klein17, Kristine E. Lee17, Xiaoyu Gao18, Michael Mauer19, Silvia Maestroni, Maria Luiza Caramori19, Ian H. de Boer20, Rachel G. Miller21, Jingchuan Guo21, Andrew P. Boright, David-Alexandre Trégouët22, David-Alexandre Trégouët23, Beata Gyorgy23, Beata Gyorgy22, Janet K. Snell-Bergeon24, David M. Maahs25, Shelley B. Bull26, Angelo J. Canty27, Colin N. A. Palmer28, Lars Stechemesser29, Bernhard Paulweber29, Raimund Weitgasser29, Jelizaveta Sokolovska30, Vita Rovīte31, Valdis Pīrāgs30, Edita Prakapiene, Lina Radzeviciene32, Rasa Verkauskiene32, Nicolae Mircea Panduru33, Nicolae Mircea Panduru4, Leif Groop12, Leif Groop4, Mark I. McCarthy, Harvest F. Gu34, Anna Möllsten35, Henrik Falhammar36, Henrik Falhammar37, Kerstin Brismar37, Kerstin Brismar36, Finian Martin6, Peter Rossing13, Peter Rossing38, Tina Costacou21, Gianpaolo Zerbini, Michel Marre, Samy Hadjadj39, Amy Jayne McKnight40, Carol Forsblom, Gareth J. McKay40, Catherine Godson6, A. Peter Maxwell40, Matthias Kretzler14, Katalin Susztak8, Helen M. Colhoun10, Andrzej S. Krolewski9, Andrew D. Paterson, Per-Henrik Groop, Stephen S. Rich5, Joel N. Hirschhorn2, Joel N. Hirschhorn3, Jose C. Florez 
TL;DR: In this paper, a large collection of type 1 diabetes cohorts with harmonized diabetic kidney disease phenotypes were assembled through collaboration with the Diabetes Nephropathy Collaborative Research Initiative, and 16 genome-wide significant risk loci were identified.
Abstract: Background Although diabetic kidney disease demonstrates both familial clustering and single nucleotide polymorphism heritability, the specific genetic factors influencing risk remain largely unknown. Methods To identify genetic variants predisposing to diabetic kidney disease, we performed genome-wide association study (GWAS) analyses. Through collaboration with the Diabetes Nephropathy Collaborative Research Initiative, we assembled a large collection of type 1 diabetes cohorts with harmonized diabetic kidney disease phenotypes. We used a spectrum of ten diabetic kidney disease definitions based on albuminuria and renal function. Results Our GWAS meta-analysis included association results for up to 19,406 individuals of European descent with type 1 diabetes. We identified 16 genome-wide significant risk loci. The variant with the strongest association (rs55703767) is a common missense mutation in the collagen type IV alpha 3 chain (COL4A3) gene, which encodes a major structural component of the glomerular basement membrane (GBM). Mutations in COL4A3 are implicated in heritable nephropathies, including the progressive inherited nephropathy Alport syndrome. The rs55703767 minor allele (Asp326Tyr) is protective against several definitions of diabetic kidney disease, including albuminuria and ESKD, and demonstrated a significant association with GBM width; protective allele carriers had thinner GBM before any signs of kidney disease, and its effect was dependent on glycemia. Three other loci are in or near genes with known or suggestive involvement in this condition (BMP7) or renal biology (COLEC11 and DDR1). Conclusions The 16 diabetic kidney disease-associated loci may provide novel insights into the pathogenesis of this condition and help identify potential biologic targets for prevention and treatment.

122 citations

Journal ArticleDOI
TL;DR: In this article, the authors investigated baseline use of biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA).
Abstract: Objective To investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA). Methods We analysed the COVID-19 Global Rheumatology Alliance physician registry (from 24 March 2020 to 12 April 2021). We investigated b/tsDMARD use for RA at the clinical onset of COVID-19 (baseline): abatacept (ABA), rituximab (RTX), Janus kinase inhibitors (JAKi), interleukin 6 inhibitors (IL-6i) or tumour necrosis factor inhibitors (TNFi, reference group). The ordinal COVID-19 severity outcome was (1) no hospitalisation, (2) hospitalisation without oxygen, (3) hospitalisation with oxygen/ventilation or (4) death. We used ordinal logistic regression to estimate the OR (odds of being one level higher on the ordinal outcome) for each drug class compared with TNFi, adjusting for potential baseline confounders. Results Of 2869 people with RA (mean age 56.7 years, 80.8% female) on b/tsDMARD at the onset of COVID-19, there were 237 on ABA, 364 on RTX, 317 on IL-6i, 563 on JAKi and 1388 on TNFi. Overall, 613 (21%) were hospitalised and 157 (5.5%) died. RTX (OR 4.15, 95% CI 3.16 to 5.44) and JAKi (OR 2.06, 95% CI 1.60 to 2.65) were each associated with worse COVID-19 severity compared with TNFi. There were no associations between ABA or IL6i and COVID-19 severity. Conclusions People with RA treated with RTX or JAKi had worse COVID-19 severity than those on TNFi. The strong association of RTX and JAKi use with poor COVID-19 outcomes highlights prioritisation of risk mitigation strategies for these people.

121 citations

Journal ArticleDOI
TL;DR: It is indicated that the intestinal microbiota determines the circulating cholesterol level and may thus represent a novel therapeutic target in the management of dyslipidemia and cardiovascular diseases.
Abstract: Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. We depleted the intestinal microbiota of hypercholesterolemic female Apoe−/− mice using broad-spectrum antibiotics. Measurement of plasma cholesterol levels as well as cholesterol synthesis and fluxes by complementary approaches showed that the intestinal microbiota strongly regulates plasma cholesterol level, hepatic cholesterol synthesis, and enterohepatic circulation. Moreover, transplant of the microbiota from humans harboring elevated plasma cholesterol levels to recipient mice induced a phenotype of high plasma cholesterol levels in association with a low hepatic cholesterol synthesis and high intestinal absorption pattern. Recipient mice phenotypes correlated with several specific bacterial phylotypes affiliated to Betaproteobacteria, Alistipes, Bacteroides, and Barnesiella taxa. These results indicate that the intestinal microbiota determines the circulating cholesterol level and may thus represent a novel therapeutic target in the management of dyslipidemia and cardiovascular diseases.

116 citations


Authors

Showing all 528 results

NameH-indexPapersCitations
Ronald M. Evans199708166722
Thierry Poynard11966864548
Heikki Joensuu10857150300
Gilles Montalescot10064158644
François Cambien9225136260
Antoine Danchin8048330219
Laurence Tiret7919425231
Karine Clément7827532185
Karine Clément7322814710
Pascal Ferré6924123969
Michael T. Osterholm6826022624
Vincent Jarlier6727817060
Florent Soubrier6722624486
Stephen H. Caldwell6630818527
Christian Funck-Brentano6426770432
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202168
202073
201950
201848
201793
201686