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Institution

Institute of Chartered Accountants of Nigeria

About: Institute of Chartered Accountants of Nigeria is a based out in . It is known for research contribution in the topics: Population & Adipose tissue. The organization has 528 authors who have published 579 publications receiving 18688 citations.


Papers
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Journal ArticleDOI
TL;DR: The authors' cohort suggests better prognosis of female compared with male heart transplant recipients, and Danon disease presents earlier in men than in women and runs a malignant course in both sexes, due to cardiac complications.
Abstract: Background: The X-linked Danon disease manifests by severe cardiomyopathy, myopathy, and neuropsychiatric problems. We designed this registry to generate a comprehensive picture of clinical present...

29 citations

Journal ArticleDOI
TL;DR: The emergence of dihydroceramides is highlighted as a new class of bioactive sphingolipids by reporting recent advances on their biological characterization and pathological implications, focusing on cancer and metabolic diseases.
Abstract: Dihydroceramides (DhCers) are a type of sphingolipids that for a long time were regarded as biologically inactive. They are metabolic intermediates of the de novo sphingolipid synthesis pathway, and are converted into ceramides (Cers) with the addition of a double bond. Ceramides are abundant in tissues and have well-established biological functions. On the contrary, dihydroceramides are less prevalent, and despite their hitherto characterization as inert lipids, studies of the past decade began to unravel their implication in various biological processes distinct from those involving ceramides. These processes include cellular stress responses and autophagy, cell growth, pro-death or pro-survival pathways, hypoxia, and immune responses. In addition, their plasma concentration has been related to metabolic diseases and shown as a long-term predictor of type 2 diabetes onset. They are thus important players and potential biomarkers in pathologies ranging from diabetes to cancer and neurodegenerative diseases. The purpose of this mini-review is to highlight the emergence of dihydroceramides as a new class of bioactive sphingolipids by reporting recent advances on their biological characterization and pathological implications, focusing on cancer and metabolic diseases.

29 citations

Journal ArticleDOI
TL;DR: A combined chemoinformatic approach for objective and systematic analysis of untargeted (1)H NMR-based metabolic profiles in quantitative genetic contexts is introduced and implemented in the powerful R/Bioconductor framework.
Abstract: High-throughput (1)H nuclear magnetic resonance (NMR) is an increasingly popular robust approach for qualitative and quantitative metabolic profiling, which can be used in conjunction with genomic techniques to discover novel genetic associations through metabotype quantitative trait locus (mQTL) mapping. There is therefore a crucial necessity to develop specialized tools for an accurate detection and unbiased interpretability of the genetically determined metabolic signals. Here we introduce and implement a combined chemoinformatic approach for objective and systematic analysis of untargeted (1)H NMR-based metabolic profiles in quantitative genetic contexts. The R/Bioconductor mQTL.NMR package was designed to (i) perform a series of preprocessing steps restoring spectral dependency in collinear NMR data sets to reduce the multiple testing burden, (ii) carry out robust and accurate mQTL mapping in human cohorts as well as in rodent models, (iii) statistically enhance structural assignment of genetically determined metabolites, and (iv) illustrate results with a series of visualization tools. Built-in flexibility and implementation in the powerful R/Bioconductor framework allow key preprocessing steps such as peak alignment, normalization, or dimensionality reduction to be tailored to specific problems. The mQTL.NMR package is freely available with its source code through the Comprehensive R/Bioconductor repository and its own website ( http://www.ican-institute.org/tools/ ). It represents a significant advance to facilitate untargeted metabolomic data processing and quantitative analysis and their genetic mapping.

29 citations

Journal ArticleDOI
TL;DR: After 5 years of follow-up, pLryGB provides greater weight loss than rLRYGB with similar rates of improvement and remission of coexisting conditions, and patients and surgeons should be aware of such results before primary and revisional bariatric surgery.

29 citations

Journal ArticleDOI
TL;DR: Considering medication to treat both obesity-related diseases and prevention of secondary effects of bariatric surgery, it is observed that overall postoperative medication costs were significantly reduced one year after surgery, especially for T2D and OSA.
Abstract: Background This study aims to determine the influence of Roux-en-Y gastric bypass (RYGB) on medication-related costs.

29 citations


Authors

Showing all 528 results

NameH-indexPapersCitations
Ronald M. Evans199708166722
Thierry Poynard11966864548
Heikki Joensuu10857150300
Gilles Montalescot10064158644
François Cambien9225136260
Antoine Danchin8048330219
Laurence Tiret7919425231
Karine Clément7827532185
Karine Clément7322814710
Pascal Ferré6924123969
Michael T. Osterholm6826022624
Vincent Jarlier6727817060
Florent Soubrier6722624486
Stephen H. Caldwell6630818527
Christian Funck-Brentano6426770432
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202168
202073
201950
201848
201793
201686