Institution
Institute of Molecular and Cell Biology
Facility•Singapore, Singapore•
About: Institute of Molecular and Cell Biology is a facility organization based out in Singapore, Singapore. It is known for research contribution in the topics: Zebrafish & Golgi apparatus. The organization has 1618 authors who have published 1940 publications receiving 121275 citations.
Topics: Zebrafish, Golgi apparatus, Gene, Transcription factor, Phosphorylation
Papers published on a yearly basis
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TL;DR: It is now becoming clear that p53 can have a much broader role and can contribute to the development, life expectancy and overall fitness of an organism.
Abstract: p53 is best known as a tumour suppressor, although recent studies have challenged the view that this is its only role. Instead, p53 has important functions in organismal development, and might contribute to a number of diseases other than cancer.
2,096 citations
University of California, Santa Barbara1, University of Texas at Austin2, University of Wrocław3, Dresden University of Technology4, University of Tartu5, Gulu University6, Middle East University7, Stockholm University8, University of the Punjab9, University of Nigeria, Nsukka10, Istanbul University11, Franklin & Marshall College12, Norwegian University of Science and Technology13, University of Algiers14, Australian National University15, Russian State University for the Humanities16, Russian Academy of Sciences17, İzmir University of Economics18, University of Social Sciences and Humanities19, Université catholique de Louvain20, Ankara University21, Pontifical Catholic University of Peru22, Cumhuriyet University23, University of the Republic24, ISCTE – University Institute of Lisbon25, The Chinese University of Hong Kong26, National Autonomous University of Mexico27, University of Pécs28, University of Constantine the Philosopher29, University of Maribor30, University of Zagreb31, University of Malaya32, Central University of Finance and Economics33, University of Crete34, University of Primorska35, Institute of Molecular and Cell Biology36, University of Amsterdam37, Catholic University of the Sacred Heart38, VU University Amsterdam39, University of Granada40, University of Delhi41, University of Havana42, Pontifical Catholic University of Rio de Janeiro43, University of Vienna44, Universiti Utara Malaysia45, Vilnius University46, University of British Columbia47, University of Sussex48, Romanian Academy49, Comenius University in Bratislava50, Slovak Academy of Sciences51, University of Monterrey52, SAS Institute53, DHA Suffa University54, Pontifical Catholic University of Chile55, South-West University "Neofit Rilski"56, University of São Paulo57, Kyung Hee University58, University of Ljubljana59
TL;DR: This work combines this large cross-cultural sample with agent-based models to compare eight hypothesized models of human mating markets and finds that this cross-culturally universal pattern of mate choice is most consistent with a Euclidean model of mate preference integration.
Abstract: Humans express a wide array of ideal mate preferences. Around the world, people desire romantic partners who are intelligent, healthy, kind, physically attractive, wealthy, and more. In order for these ideal preferences to guide the choice of actual romantic partners, human mating psychology must possess a means to integrate information across these many preference dimensions into summaries of the overall mate value of their potential mates. Here we explore the computational design of this mate preference integration process using a large sample of n = 14,487 people from 45 countries around the world. We combine this large cross-cultural sample with agent-based models to compare eight hypothesized models of human mating markets. Across cultures, people higher in mate value appear to experience greater power of choice on the mating market in that they set higher ideal standards, better fulfill their preferences in choice, and pair with higher mate value partners. Furthermore, we find that this cross-culturally universal pattern of mate choice is most consistent with a Euclidean model of mate preference integration.
1,827 citations
TL;DR: It is shown that apoptosis caused by an IAC is blocked by the caspase 8 inhibitor crmA and that IAP antagonists activate NF-κB signaling via inhibtion of cIAP1.
1,009 citations
TL;DR: It is highlighted that there are a variety of enzymes with different specificities, suggesting that individual nucleases act on distinct subpopulations of transcripts within the cell and multiple mechanisms by which mRNA degradation could be regulated.
Abstract: The degradation of eukaryotic mRNAs plays important roles in the modulation of gene expression, quality control of mRNA biogenesis and antiviral defenses. In the past five years, many of the enzymes involved in this process have been identified and mechanisms that modulate their activities have begun to be identified. In this review, we describe the enzymes of mRNA degradation and their properties. We highlight that there are a variety of enzymes with different specificities, suggesting that individual nucleases act on distinct subpopulations of transcripts within the cell. In several cases, translation factors that bind mRNA inhibit these nucleases. In addition, recent work has begun to identify distinct mRNP complexes that recruit the nucleases to transcripts through different mRNA-interacting proteins. These properties and complexes suggest multiple mechanisms by which mRNA degradation could be regulated.
835 citations
TL;DR: Using the green fluorescent protein (GFP) as a mobile artificial exon carried by a transposable P-element, a protein trap system is developed in Drosophila and it is observed that the subcellular localization of the fusion protein corresponds to the described distribution of the endogenous protein.
Abstract: In Drosophila, enhancer trap strategies allow rapid access to expression patterns, molecular data, and mutations in trapped genes. However, they do not give any information at the protein level, e.g., about the protein subcellular localization. Using the green fluorescent protein (GFP) as a mobile artificial exon carried by a transposable P-element, we have developed a protein trap system. We screened for individual flies, in which GFP tags full-length endogenous proteins expressed from their endogenous locus, allowing us to observe their cellular and subcellular distribution. GFP fusions are targeted to virtually any compartment of the cell. In the case of insertions in previously known genes, we observe that the subcellular localization of the fusion protein corresponds to the described distribution of the endogenous protein. The artificial GFP exon does not disturb upstream and downstream splicing events. Many insertions correspond to genes not predicted by the Drosophila Genome Project. Our results show the feasibility of a protein trap in Drosophila. GFP reveals in real time the dynamics of protein's distribution in the whole, live organism and provides useful markers for a number of cellular structures and compartments.
784 citations
Authors
Showing all 1623 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Nancy A. Jenkins | 155 | 741 | 101587 |
| Neal G. Copeland | 154 | 726 | 100130 |
| Stephen R. Quake | 132 | 589 | 77778 |
| David P. Lane | 129 | 568 | 90787 |
| Andromachi Tsirou | 129 | 1320 | 83661 |
| Noemi Beni | 128 | 1030 | 76201 |
| Zoltan Szillasi | 128 | 1214 | 84392 |
| Axel Ullrich | 124 | 436 | 61445 |
| Gary S. Stein | 118 | 870 | 56438 |
| Yi Zhang | 116 | 436 | 73227 |
| Jean Paul Thiery | 106 | 403 | 51843 |
| Sanjay Gupta | 99 | 902 | 35039 |
| Sydney Brenner | 95 | 340 | 54977 |
| Peng Li | 95 | 1548 | 45198 |
| Jerrold M. Ward | 95 | 467 | 39726 |