scispace - formally typeset
Search or ask a question

Showing papers by "Instituto Politécnico Nacional published in 2006"


Journal ArticleDOI
TL;DR: An overview of the structures for the DPGS based on fuel cell, photovoltaic, and wind turbines is given and the possibility of compensation for low-order harmonics is discussed.
Abstract: Renewable energy sources like wind, sun, and hydro are seen as a reliable alternative to the traditional energy sources such as oil, natural gas, or coal. Distributed power generation systems (DPGSs) based on renewable energy sources experience a large development worldwide, with Germany, Denmark, Japan, and USA as leaders in the development in this field. Due to the increasing number of DPGSs connected to the utility network, new and stricter standards in respect to power quality, safe running, and islanding protection are issued. As a consequence, the control of distributed generation systems should be improved to meet the requirements for grid interconnection. This paper gives an overview of the structures for the DPGS based on fuel cell, photovoltaic, and wind turbines. In addition, control structures of the grid-side converter are presented, and the possibility of compensation for low-order harmonics is also discussed. Moreover, control strategies when running on grid faults are treated. This paper ends up with an overview of synchronization methods and a discussion about their importance in the control

4,655 citations


Journal ArticleDOI
TL;DR: In this paper, the effect of the zinc precursor type, the aging of the starting solution, the substrate temperature and a vacuum-annealing treatment on the electrical, morphological, structural and optical properties was studied, in order to obtain conductive and transparent zinc oxide thin films.

2,780 citations


Journal ArticleDOI
20 Oct 2006-Science
TL;DR: The availability of single-cycle isolated attosecond pulses opens the way to a new regime in ultrafast physics, in which the strong-field electron dynamics in atoms and molecules is driven by the electric field of the attose Cond pulses rather than by their intensity profile.
Abstract: We generated single-cycle isolated attosecond pulses around ∼36 electron volts using phase-stabilized 5-femtosecond driving pulses with a modulated polarization state. Using a complete temporal characterization technique, we demonstrated the compression of the generated pulses for as low as 130 attoseconds, corresponding to less than 1.2 optical cycles. Numerical simulations of the generation process show that the carrier-envelope phase of the attosecond pulses is stable. The availability of single-cycle isolated attosecond pulses opens the way to a new regime in ultrafast physics, in which the strong-field electron dynamics in atoms and molecules is driven by the electric field of the attosecond pulses rather than by their intensity profile.

1,386 citations


Journal ArticleDOI
TL;DR: As a nontoxic biodegradable material, as well as an elicitor, chitosan has the potential to become a new class of plant protectant, assisting towards the goal of sustainable agriculture.

687 citations


Journal ArticleDOI
TL;DR: In this article, a hybrid system consisting of a proportional integral (PI) controller plus a generic hth harmonic resonant controller implemented in a frame rotating at the n th harmonic frequency is discussed in detail.
Abstract: Voltage source inverters connected to the grid in applications such as active rectifiers, active filters, uninterruptible power supplies, and distributed generation systems need an optimal ac current control. To obtain zero steady-state error at the fundamental frequency (i.e., unity power factor), the use of a standard integrator in a rotating frame is as effective as the use of a resonant controller in a stationary frame. However, the grid voltage harmonics influence the current controller and generate current harmonics unless several integrators in multiple rotating frames or resonant compensators in a stationary frame are adopted. In this letter, a hybrid system consisting of a proportional integral (PI) controller plus a generic hth harmonic resonant controller implemented in a frame rotating at the n th harmonic frequency is discussed in detail. The hth harmonic controller is able to decrease both the (h - n)th and (h + n)th harmonics, while the PI controller is able to decrease other harmonics if the synchronization phase signal adopted for the frame transformation is unfiltered. It is demonstrated that the use of a PI and sixth harmonic resonant compensator is effective for both positive and negative sequence fifth and seventh harmonics; hence, four harmonics are compensated with the proportional integral-resonant (PI-RES) controller implemented in a synchronous frame. Simulation and experimental tests validate the proposed analysis

662 citations


Journal ArticleDOI
Pietro Cortese, G. Dellacasa, Luciano Ramello, M. Sitta  +975 moreInstitutions (78)
TL;DR: The ALICE Collaboration as mentioned in this paper is a general-purpose heavy-ion experiment designed to study the physics of strongly interacting matter and the quark-gluon plasma in nucleus-nucleus collisions at the LHC.
Abstract: ALICE is a general-purpose heavy-ion experiment designed to study the physics of strongly interacting matter and the quark–gluon plasma in nucleus–nucleus collisions at the LHC. It currently involves more than 900 physicists and senior engineers, from both the nuclear and high-energy physics sectors, from over 90 institutions in about 30 countries.The ALICE detector is designed to cope with the highest particle multiplicities above those anticipated for Pb–Pb collisions (dNch/dy up to 8000) and it will be operational at the start-up of the LHC. In addition to heavy systems, the ALICE Collaboration will study collisions of lower-mass ions, which are a means of varying the energy density, and protons (both pp and pA), which primarily provide reference data for the nucleus–nucleus collisions. In addition, the pp data will allow for a number of genuine pp physics studies.The detailed design of the different detector systems has been laid down in a number of Technical Design Reports issued between mid-1998 and the end of 2004. The experiment is currently under construction and will be ready for data taking with both proton and heavy-ion beams at the start-up of the LHC.Since the comprehensive information on detector and physics performance was last published in the ALICE Technical Proposal in 1996, the detector, as well as simulation, reconstruction and analysis software have undergone significant development. The Physics Performance Report (PPR) provides an updated and comprehensive summary of the performance of the various ALICE subsystems, including updates to the Technical Design Reports, as appropriate.The PPR is divided into two volumes. Volume I, published in 2004 (CERN/LHCC 2003-049, ALICE Collaboration 2004 J. Phys. G: Nucl. Part. Phys. 30 1517–1763), contains in four chapters a short theoretical overview and an extensive reference list concerning the physics topics of interest to ALICE, the experimental conditions at the LHC, a short summary and update of the subsystem designs, and a description of the offline framework and Monte Carlo event generators.The present volume, Volume II, contains the majority of the information relevant to the physics performance in proton–proton, proton–nucleus, and nucleus–nucleus collisions. Following an introductory overview, Chapter 5 describes the combined detector performance and the event reconstruction procedures, based on detailed simulations of the individual subsystems. Chapter 6 describes the analysis and physics reach for a representative sample of physics observables, from global event characteristics to hard processes.

587 citations


Journal ArticleDOI
TL;DR: The notion of perfect space-time block codes (STBCs) are introduced and algebraic constructions of perfect STBCs for 2, 3, 4, and 6 antennas are presented.
Abstract: In this paper, we introduce the notion of perfect space-time block codes (STBCs). These codes have full-rate, full-diversity, nonvanishing constant minimum determinant for increasing spectral efficiency, uniform average transmitted energy per antenna and good shaping. We present algebraic constructions of perfect STBCs for 2, 3, 4, and 6 antennas

483 citations


Journal ArticleDOI
TL;DR: The state of knowledge on the effects that diabetes-like conditions exert on the cells responsible for ECM production is reviewed as well as relevant experimental and clinical data.

432 citations


Journal ArticleDOI
05 May 2006-Science
TL;DR: The most recent Cassini RADAR images of Titan show widespread regions that appear to be seas of longitudinal dunes similar to those seen in the Namib desert on Earth, and the distribution and orientation of the dunes support a model of fluctuating surface winds.
Abstract: The most recent Cassini RADAR images of Titan show widespread regions (up to 1500 kilometers by 200 kilometers) of near-parallel radar-dark linear features that appear to be seas of longitudinal dunes similar to those seen in the Namib desert on Earth. The Ku-band (2.17-centimeter wavelength) images show ∼100-meter ridges consistent with duneforms and reveal flow interactions with underlying hills. The distribution and orientation of the dunes support a model of fluctuating surface winds of ∼0.5 meter per second resulting from the combination of an eastward flow with a variable tidal wind. The existence of dunes also requires geological processes that create sand-sized (100- to 300-micrometer) particulates and a lack of persistent equatorial surface liquids to act as sand traps.

392 citations


Journal ArticleDOI
TL;DR: The different detoxification processes executed by algae are reviewed with special emphasis on those involving the peptides metallothioneins, mainly the post transcriptionally synthesized class III metallothsioneins or phytochelatins.

382 citations


Book
14 Aug 2006
TL;DR: In this article, a short sketch of two-dimensional differential geometries is presented, with a brief historical sketch of how the theory of relativity came into being and how the Petrov classification by the spinor method was introduced.
Abstract: 1. How the theory of relativity came into being (a brief historical sketch) Part I. Elements of Differential Geometry: 2. A short sketch of two-dimensional differential geometries 3. Tensors, tensor densities 4. Covariant derivatives 5. Parallel transport and geodesic lines 6. Curvature of a manifold: flat manifolds 7. Riemannian geometry 8. Symmetries of Rieman spaces, invariance of tensors 9. Methods to calculate the curvature quickly - Cartan forms and algebraic computer programs 10. The spatially homogeneous Bianchi-type spacetimes 11. The Petrov classification by the spinor method Part II. The Gravitation Theory: 12. The Einstein equations and the sources of a gravitational field 13. The Maxwell and Einstein-Maxwell equations and the Kaluza-Klein theory 14. Spherically symmetric gravitational field of isolated objects 15. Relativistic hydrodynamics and thermodynamics 16. Relativistic cosmology I: general geometry 17. Relativistic cosmology II: the Robertson-Walker geometry 18. Relativistic cosmology III: the Lemaitre-Tolman geometry 19. Relativistic cosmology IV: generalisations of L-T and related geometries 20. The Kerr solution 21. Subjects omitted in this book References.

Journal ArticleDOI
TL;DR: Experimental results and statistical models of the induced ordering are presented and several applications are discussed: image enhancement, normalization, watermarking, etc.
Abstract: While in the continuous case, statistical models of histogram equalization/specification would yield exact results, their discrete counterparts fail. This is due to the fact that the cumulative distribution functions one deals with are not exactly invertible. Otherwise stated, exact histogram specification for discrete images is an ill-posed problem. Invertible cumulative distribution functions are obtained by translating the problem in a K-dimensional space and further inducing a strict ordering among image pixels. The proposed ordering refines the natural one. Experimental results and statistical models of the induced ordering are presented and several applications are discussed: image enhancement, normalization, watermarking, etc.

Journal ArticleDOI
TL;DR: In this paper, a comparison of transmission losses for different technical transmission solutions for large offshore wind farms is presented, and further analysis regarding the economical feasibility can be performed in order to determine the most economic solutions for the transmission system of an offshore wind farm.

Book ChapterDOI
04 Sep 2006
TL;DR: In this article, the authors presented a new wireless sensor network routing protocol based on the Ant Colony Optimization metaheuristic, which is studied by simulation for several Wireless Sensor Network scenarios and the results clearly show that it minimises communication load and maximises energy savings.
Abstract: Wireless Sensor Networks are characterized by having specific requirements such as limited energy availability, low memory and reduced processing power. On the other hand, these networks have enormous potential applicability, e.g., habitat monitoring, medical care, military surveillance or traffic control. Many protocols have been developed for Wireless Sensor Networks that try to overcome the constraints that characterize this type of networks. Ant-based routing protocols can add a significant contribution to assist in the maximisation of the network lifetime, but this is only possible by means of an adaptable and balanced algorithm that takes into account the Wireless Sensor Networks main restrictions. This paper presents a new Wireless Sensor Network routing protocol, which is based on the Ant Colony Optimization metaheuristic. The protocol was studied by simulation for several Wireless Sensor Network scenarios and the results clearly show that it minimises communication load and maximises energy savings.

Journal ArticleDOI
TL;DR: In this article, the authors used gravimetric and electrochemical techniques to investigate the effect of decylamides of α-amino acids derivatives on steel surface protection in hydrochloric acid.

Journal ArticleDOI
TL;DR: In this article, an extension of the celebrated Paris law for crack propagation is given to take into account some of the deviations from the power-law regime in a simple manner using the Wohler SN curve of the material, suggesting a more general ''unified law''.
Abstract: An extension of the celebrated Paris law for crack propagation is given to take into account some of the deviations from the power-law regime in a simple manner using the Wohler SN curve of the material, suggesting a more general ''unified law''. In particular, using recent proposals by the first author, the stress intensity factor K(a) is replaced with a suitable mean over a material/structural parameter length scale Da, the ''fracture quantum''. In practice, for a Griffith crack, this is seen to correspond to increasing the effective crack length of Da, similarly to the Dugdale strip-yield models. However, instead of including explicitly information on cyclic plastic yield, short-crack behavior, crack closure, and all other detailed information needed to eventually explain the SN curve of the material, we include directly the SN curve constants as material property. The idea comes as a natural extension of the recent successful proposals by the first author to the static failure and to the infinite life envelopes. Here, we suggest a dependence of this fracture ''quantum'' on the applied stress range level such that the correct convergence towards the Wohler-like regime is obtained. Hence, the final law includes both Wohler's and Paris' material constants, and can be seen as either a generalized Wohler's SN curve law in the presence of a crack or a generalized Paris' law for cracks of any size. r 2006 Elsevier Ltd. All rights reserved.

Journal ArticleDOI
TL;DR: A ghost imaging type of second-order spatial correlation experiment of chaotic light is presented to show that the classical understanding based on the concept of statistical intensity fluctuations does not give a correct interpretation for the observation.
Abstract: Two-photon correlation phenomena, including the historical experiment of Hanbury Brown and Twiss, may have to be described quantum mechanically, regardless of whether the source of radiation is classical or quantum. Supporting this point, we present a ghost imaging type of second-order spatial correlation experiment of chaotic light to show that the classical understanding based on the concept of statistical intensity fluctuations does not give a correct interpretation for the observation. From a practical point of view, this experiment demonstrates the possibility of having high contrast lensless two-photon imaging with chaotic light, suggesting imaging applications for radiations for which no effective lens is available.

Proceedings ArticleDOI
01 Aug 2006
TL;DR: In this paper, an overview of the active methods used for islanding detection is presented, and the reported algorithms are carefully analyzed in their advantage and drawbacks and the considerations are validated by tests results obtained in accordance with the IEEE Std. 929-2000 procedure.
Abstract: For pt.I see ibid., p.420-5 (2006).This paper offers an overview of the active methods used for islanding detection. The inverter control algorithm is based on the use of harmonic compensators in order to create ideal working conditions (i.e. the PV-system produces a sinusoidal current and reject grid harmonics). This condition is the indispensable starting point to implement active islanding detection methods. In fact these methods are based on the perturbation of the ideal conditions (e.g. the injection of active/reactive power, the injection of current harmonics, or the insertion of an external capacitor). All the reported algorithms are carefully analysed in their advantage and drawbacks and the considerations are validated by tests results obtained in accordance with the IEEE Std. 929-2000 procedure

Journal ArticleDOI
TL;DR: The candidate materials for use as an external layer for the nerve guides were poly(caprolactone) (PCL), a biosynthetic blend between PCL and chitosan (CS) and a synthesised poly(ester-urethane) (PU).
Abstract: Recent efforts in scientific research in the field of peripheral nerve regeneration have been directed towards the development of artificial nerve guides. We have studied various materials with the aim of obtaining a biocompatible and biodegradable two layer guide for nerve repair. The candidate materials for use as an external layer for the nerve guides were poly(caprolactone) (PCL), a biosynthetic blend between PCL and chitosan (CS) and a synthesised poly(ester-urethane) (PU). Blending PCL, which is a biocompatible synthetic polymer, with a natural polymer enhanced the system biocompatibility and biomimetics, fastened the degradation rates and reduced the production costs. Various novel block poly(ester-urethane)s are being synthesised by our group with tailored properties for specific tissue engineering applications. One of these poly(ester-urethane)s, based on a low molecular weight poly(caprolactone) as the macrodiol, cycloesandimethanol as the chain extender and hexamethylene diisocyanate as the chain linker, was investigated for the production of melt extruded nerve guides. We studied natural polymers such as gelatin (G), poly(L-lysine) (PL) and blends between chitosan and gelatin (CS/G) as internal coatings for nerve guides. In vitro and in vivo tests were performed on PCL guides internally coated either with G or PL to determine the differences in the quality of nerve regeneration associated with the type of adhesion protein. CS/G natural blends combined the good cell adhesion properties of the protein phase with the ability to promote nerve regeneration of the polysaccharide phase. Natural blends were crosslinked both by physical and chemical crosslinking methods. In vitro neuroblast adhesion tests were performed on CS/G film samples, PCL/CS and PU guides internally coated with G to evaluate the ability of such materials towards nerve repair.

Journal ArticleDOI
TL;DR: In this paper, small particles of Ti/Ni have been synthesized by a bioreduction method and the controlling parameter was the pH of the solution where they were grown in.

Journal ArticleDOI
TL;DR: In this paper, the authors introduce a simple foraging model where individual primates follow mental maps and choose their displacements according to a maximum efficiency criterion, in a spatially disordered environment containing many trees with a heterogeneous size distribution.
Abstract: Scale-free foraging patterns are widespread among animals. These may be the outcome of an optimal searching strategy to find scarce, randomly distributed resources, but a less explored alternative is that this behaviour may result from the interaction of foraging animals with a particular distribution of resources. We introduce a simple foraging model where individual primates follow mental maps and choose their displacements according to a maximum efficiency criterion, in a spatially disordered environment containing many trees with a heterogeneous size distribution. We show that a particular tree-size frequency

Journal ArticleDOI
TL;DR: The study indicates that nitrogen, and in some cases carbon, isotopes can be used to assess reproductive strategies in marine mammals and when coupled with accurate age estimates based on bone growth regressions can be applied to historical or fossil otariids to gain insight into the flexibility of maternal strategies within and across species.
Abstract: We examine the utility of stable carbon and nitrogen isotope variations to characterize the length of the nursing/lactation period and age at weaning for two northern Pacific otariid species, the northern fur seal (Callorhinus ursinus) and California sea lion (Zalophus californianus). We used two sampling strategies to measure ontogenetic trends in isotope value, and compared our results to observational data on the reproductive strategies used by these otariids. For Zalophus, we found evidence for 15 N enrichment and 13 C-depletion in bone collagen representing the first and second year of growth, which is consistent with the ∼12‐14-mo weaning age in this population after a suitable turnover rate for bone collagen is considered. Analysis of individual tooth annuli from a different suite of Zalophus specimens suggests that half of the individuals were weaned at ∼12 mo of age, and half were dependent on milk for a portion of their second year. For Callorhinus, bone collagen for age classes that contain pre-weaned individuals were 15 N-enriched, but values were significantly lower in specimens between 6 and 20 mo of age. These 15 N-enriched values, presumably acquired during nursing between 0 and 4 mo of age in Callorhinus, were not present in specimens older than 12 mo of age. Thus complete bone collagen turnover in young-of-the-year occurs in 8‐10 mo. 15 N enrichment is evident in the first annulus of female Callorhinus individuals, but is not detectable in males. Analyses of Callorhinus tooth annuli show no ontogenetic trends in � 13 C values. Our study indicates that nitrogen, and in some cases carbon, isotopes can be used to assess reproductive strategies in marine mammals. When coupled with accurate age estimates based on bone growth regressions, this isotopic technique can be applied to historical or fossil otariids to gain insight into the flexibility of maternal strategies within and across species.

Journal ArticleDOI
TL;DR: In this paper, a real-time simulation code based on a lumped, nonlinear representation of gas turbine components is presented, which is a general-purpose simulation software environment useful for setting up and testing control equipments.
Abstract: A high-fidelity real-time simulation code based on a lumped, nonlinear representation of gas turbine components is presented. The code is a general-purpose simulation software environment useful for setting up and testing control equipments. The mathematical model and the numerical procedure are specially developed in order to efficiently solve the set of algebraic and ordinary differential equations that describe the dynamic behavior of gas turbine engines. For high-fidelity purposes, the mathematical model takes into account the actual composition of the working gases and the variation of the specific heats with the temperature, including a stage-by-stage model of the air-cooled expansion. The paper presents the model and the adopted solver procedure. The code, developed in Matlab-Simulink using an object-oriented approach, is flexible and can be easily adapted to any kind of plant configuration. Simulation tests of the transients after load rejection have been carried out for a single-shaft heavy-duty gas turbine and a double-shaft aero-derivative industrial engine. Time plots of the main variables that describe the gas turbine dynamic behavior are shown and the results regarding the computational time per time step are discussed.

Journal ArticleDOI
TL;DR: Some wild and weedy beans are good sources of phenolic compounds for use in breeding programs focused on nutrition and health, and the wide variation observed in polyphenolic contents was more related to their genotype than to the color factor.
Abstract: The polyphenolic composition of 62 wild and weedy Mexican bean collections from diverse origins, grouped by their seed coat color, was assessed. According to spectrophotometric analysis, the range of total phenols, condensed tannins, and total anthocyanins presented wide differences. Furthermore, the phenolic acid, flavonoid, and anthocyanin profiles were analyzed using HPLC. Ferulic was the main phenolic acid. Kaempferol and quercetin were the main flavonoids, and the isoflavones daidzein and coumestrol were found in only low levels in few collections. Delphinidin was the main anthocyanidin found, followed by petunidin, cyanidin, malvidin, pelargonidin, and peonidin. The wide variation observed in polyphenolic contents was more related to their genotype than to the color factor. These results show that some wild and weedy beans are good sources of phenolic compounds for use in breeding programs focused on nutrition and health.

Journal ArticleDOI
TL;DR: A state-of-the-art method for solving the preconditioned compressible Navier–Stokes equations accurately and efficiently for a wide range of the Mach number with an immersed-boundary approach which allows one to use Cartesian grids for arbitrarily complex geometries is combined.

Journal ArticleDOI
TL;DR: It is proposed that the changes observed in the pro/anti-inflammatory Th1/Th2 cytokine balance in MDD patients and in non-depressed control group could be related to the elevated cortisol levels seen in the patients.

Journal ArticleDOI
TL;DR: In this article, the authors proposed a discrete version of the original GW model, keeping the approximation of a surface by quadratic functions near summits, where the summit arrangement is found from numerical realizations or real surfaces scans.
Abstract: Greenwood and Williamson in 1966 (GW) proposed a theory of elastic contact mechanics of rough surfaces which is today the foundation of many theories in tribology (friction, adhesion, thermal and electrical conductance, wear, etc.). However, the theory has periodically received criticisms for the “resolution-dependence” of the asperity features. Greenwood himself has recently concluded that: “The introduction by Greenwood and Williamson in 1966 of the definition of a ‘peak’ as a point higher than its neighbours on a profile sampled at a finite sampling interval was, in retrospect, a mistake, although it is possible that it was a necessary mistake” [Greenwood and Wu, 2001. Surface roughness and contact: an apology. Meccanica 36 (6), 617–630]. We propose a “discrete” version of the GW model, keeping the approximation of a surface by quadratic functions near summits, where the summit arrangement is found from numerical realizations or real surfaces scans. The contact is then solved either summing the Hertzian relationships, or considering interaction effects to the first-order in a very efficient algorithm. We conduct experiments on Weierstrass–Mandelbrot fractal surfaces, concluding that: (1) the real contact area–load relationship is well captured by the original GW theoretical model, once the correct mean radius is used. The relationship is robust and shows relatively little scatter; (2) the conductance–load relationship is vice versa only approximately given by the original GW theoretical model. Significant deviations from linearity and significant scatter seem to be found, particularly at low fractal dimensions; (3) the load, area and conductance dependences with separation show significant dependence on the actual phase arrangements, and hence significant scatter at large separations. Effect of interaction is seen strongly at low separations, where scatter is minimal. The discrete GW model permits to include these effects, except when the asperity description breaks down. Refinements of the original GW theory using the full random process theory (such as that by Bush Gibson and Thomas, BGT) result only in small improvements with a significant additional complication. However, the BGT relationship between contact area and load at low loads is more accurate than the more recent theory by Persson. The distribution derived from the original GW theory has been obtained, and shown to be closer to the numerical results than that predicted by the Persson model, even if the area error is removed. It is concluded that the original GW theory deserves the general success received so far, since the resolution-dependence of geometrical features is an intrinsic feature of “fractals” but not a problem for the GW theory, when interaction effects are included.

Journal Article
TL;DR: Lipase production in Aspergillus niger J-1 was tested using both submerged fermentation (SmF) and solid-state fermentation (SSF) on a mineral culture medium and wheat bran, respectively and the optimization of the culture medium was carried out for both SmF and SSF.
Abstract: Summary Lipase production in Aspergillus niger J-1 was tested using both submerged fermentation (SmF) and solid-state fermentation (SSF) on a mineral culture medium and wheat bran, respectively. The optimization of the culture medium was carried out for both SmF and SSF. The maximum lipase activity, 1.46 IU/mL, was obtained during the submerged fermentation in a medium containing glucose at 2 % and olive oil at 2 % under conditions of 1 vvm and 450 m –1 . However, 9.14 IU/g of dry solid substrate equivalent to 4.8 IU/mL of lipase activity was reached using solid-state fermentation process with a medium containing 0.75 % of ammonium sulphate and 0.34 % of urea. The optimum pH and temperature for enzymatic activity were pH=6 and 40 °C, respectively. The enzyme also exhibited 80 % of its initial activity in neutral and mildly acid media and at temperatures between 20 and 30 °C for a period of 24 hours.

Journal ArticleDOI
TL;DR: ADR under- reporting is strongly associated with certain attitudes, possibly indicating that under-reporting could be minimised through educational interventions targeted at changing such attitudes.
Abstract: Introduction: Pharmacists can play a fundamental role in adverse drug reaction (ADR) reporting, although the factors that affect underreporting among these professionals are unknown. The objectives of this study were to identify (i) professional or demographic characteristics; and (ii) attitudes associated with pharmacists’ ADR reporting in northern Portugal.

Journal ArticleDOI
TL;DR: It is concluded that NDGA is a potent in vitro scavenger of ONOO−, 1O2, OH√, and HOCl and is able to prevent lung tyrosine nitration in vivo.
Abstract: The antioxidant nordihydroguaiaretic acid (NDGA) has recently become well known as a putative anticancer drug. In this paper, it was evaluated the in vitro peroxynitrite (ONOO(-)), singlet oxygen ((1)O(2)), hydroxyl radical (OH(v)), hydrogen peroxide (H(2)O(2)), superoxide anion and hypochlorous acid (HOCl) scavenging capacity of NDGA. It was found that NDGA scavenges: (a) ONOO(-) (IC(50) = 4 +/- 0.94 microM) as efficiently as uric acid; (b) (1)O(2) (IC(50) = 151 +/- 20 microM) more efficiently than dimethyl thiourea, lipoic acid, N-acetyl-cysteine and glutathione; (c) OH(v) (IC(50) = 0.15 +/- 0.02 microM) more efficiently than dimethyl thiourea, uric acid, trolox, dimethyl sulfoxide and mannitol, (d) (IC(50) = 15 +/- 1 microM) more efficiently than N-acetyl-cysteine, glutathione, tempol and deferoxamine and (e) HOCl (IC(50) = 622 +/- 42 microM) as efficiently as lipoic acid and N-acetyl-cysteine. NDGA was unable to scavenge H(2)O(2). In an in vivo study in rats, NDGA was able to prevent ozone-induced tyrosine nitration in lungs. It is concluded that NDGA is a potent in vitro scavenger of ONOO(-), (1)O(2), OH(v), and HOCl and is able to prevent lung tyrosine nitration in vivo.