Showing papers by "Instituto Politécnico Nacional published in 2011"
TL;DR: The engineered SO coupling in a neutral atomic Bose–Einstein condensate sets the stage for the realization of topological insulators in fermionic neutral atom systems and develops a many-body theory that provides quantitative agreement with the observed location of the transition.
Abstract: Spin-orbit coupling describes the interaction between a quantum particle's spin and its momentum, and is important for many areas of physics from spintronics to the quantum spin Hall effect and topological insulators. However, in systems of ultracold neutral atoms, there is no coupling between the spin and the centre-of-mass motion of the atom. Lin et al. use lasers to engineer such spin-orbit coupling in a neutral atomic Bose–Einstein condensate, the first time this has been achieved for any bosonic system. This should lead to the realization of topological insulators in fermionic neutral atom systems. Spin–orbit coupling describes the interaction between a quantum particle's spin and its momentum, and is important for many areas of physics such as spintronics and topological insulators. However, in systems of ultracold neutral atoms, there is no coupling between the spin and the centre of mass motion of the atom. This study uses lasers to engineer such spin–orbit coupling in a neutral atomic Bose–Einstein condensate, the first time this has been achieved for any bosonic system. This should lead to the realization of topological insulators in fermionic neutral atom systems. Spin–orbit (SO) coupling—the interaction between a quantum particle’s spin and its momentum—is ubiquitous in physical systems. In condensed matter systems, SO coupling is crucial for the spin-Hall effect1,2 and topological insulators3,4,5; it contributes to the electronic properties of materials such as GaAs, and is important for spintronic devices6. Quantum many-body systems of ultracold atoms can be precisely controlled experimentally, and would therefore seem to provide an ideal platform on which to study SO coupling. Although an atom’s intrinsic SO coupling affects its electronic structure, it does not lead to coupling between the spin and the centre-of-mass motion of the atom. Here, we engineer SO coupling (with equal Rashba7 and Dresselhaus8 strengths) in a neutral atomic Bose–Einstein condensate by dressing two atomic spin states with a pair of lasers9. Such coupling has not been realized previously for ultracold atomic gases, or indeed any bosonic system. Furthermore, in the presence of the laser coupling, the interactions between the two dressed atomic spin states are modified, driving a quantum phase transition from a spatially spin-mixed state (lasers off) to a phase-separated state (above a critical laser intensity). We develop a many-body theory that provides quantitative agreement with the observed location of the transition. The engineered SO coupling—equally applicable for bosons and fermions—sets the stage for the realization of topological insulators in fermionic neutral atom systems.
1,468 citations
TL;DR: Two separate gamma-ray flares from a young and energetic pulsar powers the well-known Crab Nebula are described and it is suggested that the gamma rays were emitted via synchrotron radiation from peta–electron-volt electrons in a region smaller than 1.4 × 10−2 parsecs.
Abstract: A young and energetic pulsar powers the well-known Crab Nebula. Here, we describe two separate gamma-ray (photon energy greater than 100 mega-electron volts) flares from this source detected by the Large Area Telescope on board the Fermi Gamma-ray Space Telescope. The first flare occurred in February 2009 and lasted approximately 16 days. The second flare was detected in September 2010 and lasted approximately 4 days. During these outbursts, the gamma-ray flux from the nebula increased by factors of four and six, respectively. The brevity of the flares implies that the gamma rays were emitted via synchrotron radiation from peta-electron-volt (10(15) electron volts) electrons in a region smaller than 1.4 × 10(-2) parsecs. These are the highest-energy particles that can be associated with a discrete astronomical source, and they pose challenges to particle acceleration theory.
395 citations
TL;DR: In this paper, the gamma-ray activity of the high-synchrotron-peaked BL Lacertae object Markarian 421 (Mrk 421) during the first 1.5 years of Fermi operation was reported.
Abstract: We report on the gamma-ray activity of the high-synchrotron-peaked BL Lacertae object Markarian 421 (Mrk 421) during the first 1.5 years of Fermi operation, from 2008 August 5 to 2010 March 12. We find that the Large Area Telescope (LAT) gamma-ray spectrum above 0.3 GeV can be well described by a power-law function with photon index Gamma = 1.78 +/- 0.02 and average photon flux F(>0.3 GeV) = (7.23 +/- 0.16) x 10(-8) ph cm(-2) s(-1). Over this time period, the Fermi-LAT spectrum above 0.3 GeV was evaluated on seven-day-long time intervals, showing significant variations in the photon flux (up to a factor similar to 3 from the minimum to the maximum flux) but mild spectral variations. The variability amplitude at X-ray frequencies measured by RXTE/ASM and Swift/BAT is substantially larger than that in gamma-rays measured by Fermi-LAT, and these two energy ranges are not significantly correlated. We also present the first results from the 4.5 month long multifrequency campaign on Mrk 421, which included the VLBA, Swift, RXTE, MAGIC, the F-GAMMA, GASP-WEBT, and other collaborations and instruments that provided excellent temporal and energy coverage of the source throughout the entire campaign (2009 January 19 to 2009 June 1). During this campaign, Mrk 421 showed a low activity at all wavebands. The extensive multi-instrument (radio to TeV) data set provides an unprecedented, complete look at the quiescent spectral energy distribution (SED) for this source. The broadband SED was reproduced with a leptonic (one-zone synchrotron self-Compton) and a hadronic model (synchrotron proton blazar). Both frameworks are able to describe the average SED reasonably well, implying comparable jet powers but very different characteristics for the blazar emission site.
357 citations
TL;DR: In this paper, the Fermi Large Area Telescope (LAT) was used to detect a source positionally coincident with the young supernova remnant (SNR) RX J1713.7-3946.
Abstract: We present observations of the young Supernova remnant (SNR) RX J1713.7-3946 with the Fermi Large Area Telescope (LAT). We clearly detect a source positionally coincident with the SNR. The source is extended with a best-fit extension of 0.55$^{\circ} \pm 0.04^{\circ}$ matching the size of the non-thermal X-ray and TeV gamma-ray emission from the remnant. The positional coincidence and the matching extended emission allows us to identify the LAT source with the supernova remnant RX J1713.7-3946. The spectrum of the source can be described by a very hard power-law with a photon index of $\Gamma = 1.5 \pm 0.1$ that coincides in normalization with the steeper H.E.S.S.-detected gamma-ray spectrum at higher energies. The broadband gamma-ray emission is consistent with a leptonic origin as the dominant mechanism for the gamma-ray emission.
302 citations
TL;DR: Recent developments in the area of third‐generation ionic liquids that are being used as APIs, with a particular focus on efforts to overcome current hurdles encountered by APIs, are summarized.
Abstract: Ionic liquids (ILs) are ionic compounds that possess a melting temperature below 100 °C. Their physical and chemical properties are attractive for various applications. Several organic materials that are now classified as ionic liquids were described as far back as the mid-19th century. The search for new and different ILs has led to the progressive development and application of three generations of ILs: 1) The focus of the first generation was mainly on their unique intrinsic physical and chemical properties, such as density, viscosity, conductivity, solubility, and high thermal and chemical stability. 2) The second generation of ILs offered the potential to tune some of these physical and chemical properties, allowing the formation of "task-specific ionic liquids" which can have application as lubricants, energetic materials (in the case of selective separation and extraction processes), and as more environmentally friendly (greener) reaction solvents, among others. 3) The third and most recent generation of ILs involve active pharmaceutical ingredients (API), which are being used to produce ILs with biological activity. Herein we summarize recent developments in the area of third-generation ionic liquids that are being used as APIs, with a particular focus on efforts to overcome current hurdles encountered by APIs. We also offer some innovative solutions in new medical treatment and delivery options.
297 citations
TL;DR: In this paper, the forward-backward asymmetry in top quark-antiquark production in proton-antiproton collisions in the final state containing a lepton and at least four jets was measured.
Abstract: We present a measurement of forward-backward asymmetry in top quark-antiquark production in proton-antiproton collisions in the final state containing a lepton and at least four jets. Using a dataset corresponding to an integrated luminosity of $5.4\,\mathrm {fb}^{-1}$, collected by the \DZ\ experiment at the Fermilab Tevatron Collider, we measure the \ttbar\ forward-backward asymmetry to be $(9.2 \pm 3.7)$% at the reconstruction level. When corrected for detector acceptance and resolution, the asymmetry is found to be $(19.6 \pm 6.5)$%. We also measure a corrected asymmetry based on the lepton from a top quark decay, found to be $(15.2 \pm 4.0)$%. The results are compared to predictions based on the next-to-leading-order QCD generator {\sc mc@nlo}. The sensitivity of the measured and predicted asymmetries to the modeling of gluon radiation is discussed.
285 citations
TL;DR: The Fermi Large Area Telescope has observed the star-forming region of Cygnus X and reveals a 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stellar winds and ionization fronts from young stellar clusters.
Abstract: The origin of Galactic cosmic rays is a century-long puzzle. Indirect evidence points to their acceleration by supernova shockwaves, but we know little of their escape from the shock and their evolution through the turbulent medium surrounding massive stars. Gamma rays can probe their spreading through the ambient gas and radiation fields. The Fermi Large Area Telescope (LAT) has observed the star-forming region of Cygnus X. The 1- to 100-gigaelectronvolt images reveal a 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stellar winds and ionization fronts from young stellar clusters. It provides an example to study the youth of cosmic rays in a superbubble environment before they merge into the older Galactic population.
282 citations
TL;DR: In this article, the authors investigated the role of market-related exploitative and explorative capabilities, together with product development ones, in the context of exporting and found that entrepreneurial orientation is a precursor of exploitative, explorative product development and overseas market related capabilities.
274 citations
TL;DR: The flat-spectrum radio quasar 3C454.3 underwent an extraordinary 5-day γ-ray outburst in 2010 November when the daily flux measured with the Fermi Large Area Telescope (LAT) at photon energies E > 100 MeV reached (66 ± 2) × 10−6 photons cm−2 s−1, which is a factor of three higher than its previous maximum flux recorded in 2009 December and 5 times brighter than the Vela pulsar as mentioned in this paper.
Abstract: The flat-spectrum radio quasar 3C454.3 underwent an extraordinary 5 day γ -ray outburst in 2010 November when the daily flux measured with the Fermi Large Area Telescope (LAT) at photon energies E > 100 MeV reached (66 ± 2) × 10−6 photons cm−2 s−1. This is a factor of three higher than its previous maximum flux recorded in 2009 December and 5 times brighter than the Vela pulsar, which is normally the brightest source in the γ -ray sky. The 3 hr peak flux was (85 ± 5)×10−6 photons cm−2 s−1, corresponding to an apparent isotropic luminosity of (2.1 ± 0.2)×1050 erg s−1, the highest ever recorded for a blazar. In this Letter, we investigate the features of this exceptional event in the γ -ray band of the Fermi-LAT. In contrast to previous flares of the same source observed with the Fermi-LAT, clear spectral changes are observed during the flare.
251 citations
TL;DR: In this paper, an adsorption study of hexane and xylene isomers mixtures was addressed in a rigid zirconium terephthalate UiO-66 (UiO for University of Oslo) with octahedral and tetrahedral cavities of free diameter close to 1.1nm and 0.8nm, respectively.
247 citations
23 Feb 2011
TL;DR: A Quality Adaptation Controller for live adaptive video streaming designed by employing feedback control theory and found to be able to throttle the video quality to match the available bandwidth with a transient of less than 30s while ensuring a continuous video reproduction.
Abstract: Multimedia content feeds an ever increasing fraction of the Internet traffic. Video streaming is one of the most important applications driving this trend. Adaptive video streaming is a relevant advancement with respect to classic progressive download streaming such as the one employed by YouTube. It consists in dynamically adapting the content bitrate in order to provide the maximum Quality of Experience, given the current available bandwidth, while ensuring a continuous reproduction. In this paper we propose a Quality Adaptation Controller (QAC) for live adaptive video streaming designed by employing feedback control theory. An experimental comparison with Akamai adaptive video streaming has been carried out. We have found the following main results: 1) QAC is able to throttle the video quality to match the available bandwidth with a transient of less than 30s while ensuring a continuous video reproduction; 2) QAC fairly shares the available bandwidth both in the cases of a concurrent TCP greedy connection or a concurrent video streaming flow; 3) Akamai underutilizes the available bandwidth due to the conservativeness of its heuristic algorithm; moreover, when abrupt available bandwidth reductions occur, the video reproduction is affected by interruptions.
TL;DR: In this article, the authors present an overview on microalgae with particular emphasis as a source for energy (biofuel/electricity) and new materials and discuss the critical issues involved in production of micro algae and their use, future R&D to overcome these, including the work initiated by the Federal University of Parana, UFPR, in Brazil are discussed.
Abstract: Increasing energy demands, predicted fossil fuels shortage in the near future, and environmental concerns due to the production of greenhouse gas carbon dioxide on their combustion have motivated the search for alternative ‘clean’ energy sources. Among many resources for this, microalgae have been found to be most promising due to their high production capacity of vegetable oils. They possess a high growth rate, need abundantly available solar light and CO2, and thus are more photosynthetically efficient than oil crops. Also, they tolerate high concentration of salts allowing the use of any type of water for the agriculture and the possibility of production using innovative compact photobioreactors. In addition, microalgae are a potential source of biomass, which may have great biodiversity and consequent variability in their biochemical composition. This paper presents an overview on microalgae with particular emphasis as a source for energy (biofuel/electricity) and new materials. Critical issues involved in production of microalgae and their use, future R & D to overcome these, including the work initiated by the authors at Federal University of Parana, UFPR, in Brazil are discussed. Copyright © 2010 John Wiley & Sons, Ltd.
TL;DR: In this paper, the physical mechanism behind the enhanced adhesion of mushroom-shaped adhesive microstructures is explained theoretically and a tool to predict adhesive performance depending on the geometry, mechanical properties of the material, and energy of adhesion is presented.
Abstract: The superlative adhesive properties of some biological attachment systems, such as those of geckos, spiders, and insects, have inspired researchers from different fields (e.g. biology, physics and engineering) to conceive and design man-made microstructured surfaces that might mimic their performance. Among the several proposed designs, very recently mushroom-shaped adhesive microstructures have drawn the interest of scientists and engineers, because experiments have proved their superiority compared to other micro- and nano-structures. In this article, we explain theoretically the physical mechanism behind the enhanced adhesion of such microstructures, and provide for the first time a useful tool to predict adhesive performance depending on the geometry, mechanical properties of the material, and energy of adhesion. Our theoretical predictions are strongly supported by the available experimental data. The present study can streamline the optimisation of adhesive microstructures for industrial applications.
TL;DR: In this paper, the authors examine the need for large-scale, sustainable changes, and the effects of citizens' active participation and design co-operating to realize such changes, concluding that when participatory design is intended as an approach aiming at broad and complex transformation processes its t...
Abstract: This paper examines the need for large-scale, sustainable changes, and the effects of citizens' active participation and design co-operating to realise such changes. Section 1, starting from Pelle Ehn's last contribution, deals with participatory design and how it can be extended from the traditional idea of participation as the integration of users in projects, to the concept of participation as the interaction of active groups of citizens with open and articulated processes in the direction of socio-technical changes. Section 2 introduces the idea of planning by projects strategy and presents five design projects. Section 3 discusses how participatory design can be extended to give a rationale for these large-scale projects and what designers did in practice: triggered citizens’ interest, aligned their motivations and empowered their capabilities. The idea emerging from this discussion is that when participatory design is intended as an approach aiming at broad and complex transformation processes its t...
TL;DR: It is shown how these families can be conveniently viewed within a common ejection chain framework which sheds light on their similarities and differences, and gives clues about the nature of potential enhancements to today's best methods that may provide additional gains in solving large and difficult TSPs.
TL;DR: In this article, the principal component analysis (PCA) was used to identify volatile and non-volatile compounds produced during the fermentation-drying process of cacao beans, and relations between compounds and fermentation and drying day were associated with dynamics of these compounds.
TL;DR: In this paper, the authors studied the performance of three types of bifunctional catalysts: Pt/H-Y, Pt/ZSM-5, and sulfided NiMo/γ-Al2O3.
Abstract: As an alternative way to produce diesel hydrocarbons, the hydrocracking of rapeseed oil was studied on three different types of bifunctional catalysts: Pt/H-Y, Pt/H-ZSM-5, and sulfided NiMo/γ-Al2O3. Experiments were carried out in a batch reactor over a temperature range of 300−400 °C and initial hydrogen pressures from 5 to 11 MPa. The reaction time was limited to 3 h to prevent a high degree of cracking. The Pt-zeolite catalysts had a strong catalytic activity for both cracking and hydrogenation reactions, and therefore a higher severity was required to reach a relatively high oil conversion into liquid hydrocarbons. With dependence on the activity of the acid sites of the catalysts, the results show a trade-off between the yield of green diesel and the degree of isomerization, which had a direct effect on the cold properties of the diesel. Among the three catalysts, hydrocracking on Ni-Mo/γ-Al2O3 gave the highest yield of liquid hydrocarbons in the boiling range of the diesel fraction, i.e., green dies...
TL;DR: This study confirms a previously reported, but frequently questioned, association between exposure to iAs and diabetes, and is the first to link the risk of diabetes to the production of one of the most toxic metabolites of iAs, DMAsIII.
Abstract: Human exposures to inorganic arsenic (iAs) have been linked to an increased risk of diabetes mellitus. Recent laboratory studies showed that methylated trivalent metabolites of iAs may play key roles in the diabetogenic effects of iAs. Our study examined associations between chronic exposure to iAs in drinking water, metabolism of iAs, and prevalence of diabetes in arsenicosis-endemic areas of Mexico. We used fasting blood glucose (FBG), fasting plasma insulin (FPI), oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), and insulin resistance (HOMA-IR) to characterize diabetic individuals. Arsenic levels in drinking water and urine were determined to estimate exposure to iAs. Urinary concentrations of iAs and its trivalent and pentavalent methylated metabolites were measured to assess iAs metabolism. Associations between diabetes and iAs exposure or urinary metabolites of iAs were estimated by logistic regression with adjustment for age, sex, hypertension and obesity. The prevalence of diabetes was positively associated with iAs in drinking water (OR 1.13 per 10 ppb, p < 0.01) and with the concentration of dimethylarsinite (DMAsIII) in urine (OR 1.24 per inter-quartile range, p = 0.05). Notably, FPI and HOMA-IR were negatively associated with iAs exposure (β -2.08 and -1.64, respectively, p < 0.01), suggesting that the mechanisms of iAs-induced diabetes differ from those underlying type-2 diabetes, which is typically characterized by insulin resistance. Our study confirms a previously reported, but frequently questioned, association between exposure to iAs and diabetes, and is the first to link the risk of diabetes to the production of one of the most toxic metabolites of iAs, DMAsIII.
20 Jun 2011
TL;DR: While the RTT between users and data centers plays a role in the video server selection process, a variety of other factors may influence this selection including load-balancing, diurnal effects, variations across DNS servers within a network, limited availability of rarely accessed video, and the need to alleviate hot-spots that may arise due to popular video content.
Abstract: In this paper, we conduct a detailed study of the YouTube CDN with a view to understanding the mechanisms and policies used to determine which data centers users download video from. Our analysis is conducted using week-long datasets simultaneously collected from the edge of five networks - two university campuses and three ISP networks - located in three different countries. We employ state-of-the-art delay-based geolocation techniques to find the geographical location of YouTube servers. A unique aspect of our work is that we perform our analysis on groups of related YouTube flows. This enables us to infer key aspects of the system design that would be difficult to glean by considering individual flows in isolation. Our results reveal that while the RTT between users and data centers plays a role in the video server selection process, a variety of other factors may influence this selection including load-balancing, diurnal effects, variations across DNS servers within a network, limited availability of rarely accessed video, and the need to alleviate hot-spots that may arise due to popular video content.
TL;DR: In this paper, the authors reported the discovery of 100 MeV γ -rays from the binary system PSR B1259−63/LS 2883 using the Large Area Telescope (LAT) on board Fermi.
Abstract: We report on the discovery of 100 MeV γ -rays from the binary system PSR B1259−63/LS 2883 using the Large Area Telescope (LAT) on board Fermi. The system comprises a radio pulsar in orbit around a Be star. We report on LAT observations from near apastron to ∼128 days after the time of periastron, tp, on 2010 December 15. No γ -ray emission was detected from this source when it was far from periastron. Faint γ -ray emission appeared as the pulsar approached periastron. At ∼tp + 30 days, the 100 MeV γ -ray flux increased over a period of a few days to a peak flux 20-30 times that seen during the pre-periastron period, but with a softer spectrum. For the following month, it was seen to be variable on daily timescales, but remained at ∼(1-4) × 10−6 cm−2 s−1 before starting to fade at ∼tp +57 days. The total γ -ray luminosity observed during this period is comparable to the spin-down power of the pulsar. Simultaneous radio and X-ray observations of the source showed no corresponding dramatic changes in radio and X-ray flux between the pre-periastron and post-periastron flares. We discuss possible explanations for the observed γ -ray-only flaring of the source.
21 Mar 2011
TL;DR: A novel module developed for the simulation of the LTE technology with the ns-3 simulator focuses mainly on modeling the E-UTRA part of the system, with a particular attention on the aspects related to the channel, PHY and MAC layers.
Abstract: In this paper, we present a novel module developed for the simulation of the LTE technology with the ns-3 simulator. It focuses mainly on modeling the E-UTRA part of the system, with a particular attention on the aspects related to the channel, PHY and MAC layers. First we discuss the overall modeling assumptions according to which the module was designed. Subsequently, we describe in detail the architecture of the module and its components. Finally, we discuss an example simulation scenario.
TL;DR: In this article, the passivation and passivation breakdown of AISI 304 in alkaline solutions of different pH (pH from 13 to 9), simulating the interstitial concrete electrolyte was studied.
TL;DR: In this article, the chemical constituents (phenolic compounds, macronutrients, sugars, fatty acids, tocopherols and ascorbic acid) of four wild edible mushrooms widely appreciated in gastronomy were described and compared.
TL;DR: In this paper, a high-pressure fixed-bed flow reaction system was used to produce bio-hydrogenated diesel and liquefied petroleum gas (LPG) fuel from jatropha oil.
Abstract: Biohydrogenated diesel (BHD) and liquefied petroleum gas (LPG) fuel were produced by the hydrotreatment of vegetable oils over Ni–Mo-based catalysts in a high-pressure fixed-bed flow reaction system at 350 °C under 4 MPa of hydrogen. Because triglycerides and free fatty acids underwent the hydrogenation and deoxidization at the same time during the reaction, various vegetable oils (jatropha oil, palm oil, and canola oil) were converted to mixed paraffins by the one-step hydrotreatment process although they contained quite different amounts of free fatty acids. Ni-Mo/SiO2 formed n-C18H38, n-C17H36, n-C16H34, and n-C15H32 as predominant products in the hydrotreatment of jatropha oil. These long normal hydrocarbons had high melting points and thus gave the liquid hydrocarbon product over Ni-Mo/SiO2 a high pour point of 20 °C. Either Ni-Mo/H-Y or Ni-Mo/H-ZSM-5 was not suitable for producing BHD from jatropha oil because a large amount of gasoline-ranged hydrocarbons was formed on the strong acid sites of zeol...
TL;DR: In this article, a detailed statistical analysis of the correlation between radio and gamma-ray emission of the active galactic nuclei (AGNs) detected by Fermi during its first year of operation, with the largest data sets ever used for this purpose, is presented.
Abstract: We present a detailed statistical analysis of the correlation between radio and gamma-ray emission of the active galactic nuclei (AGNs) detected by Fermi during its first year of operation, with the largest data sets ever used for this purpose We use both archival interferometric 84 GHz data (from the Very Large Array and ATCA, for the full sample of 599 sources) and concurrent single-dish 15 GHz measurements from the Owens Valley Radio Observatory (OVRO, for a sub sample of 199 objects) Our unprecedentedly large sample permits us to assess with high accuracy the statistical significance of the correlation, using a surrogate data method designed to simultaneously account for common-distance bias and the effect of a limited dynamical range in the observed quantities We find that the statistical significance of a positive correlation between the centimeter radio and the broadband (E > 100 MeV) gamma-ray energy flux is very high for the whole AGN sample, with a probability of < 10(-7) for the correlation appearing by chance Using the OVRO data, we find that concurrent data improve the significance of the correlation from 16 x 10(-6) to 90 x 10(-8) Our large sample size allows us to study the dependence of correlation strength and significance on specific source types and gamma-ray energy band We find that the correlation is very significant (chance probability < 10(-7)) for both flat spectrum radio quasars and BL Lac objects separately; a dependence of the correlation strength on the considered gamma-ray energy band is also present, but additional data will be necessary to constrain its significance
TL;DR: It is demonstrated that autophagy is a key degradation pathway, with beclin-1 playing a significant role in alleviating Machado-Joseph disease pathogenesis.
Abstract: Machado–Joseph disease, also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 misfolding, intracellular accumulation of aggregates and neuronal degeneration. Here we investigated the implication of autophagy, the major pathway for organelle and protein turnover, in the accumulation of mutant ataxin-3 aggregates and neurodegeneration found in Machado–Joseph disease and we assessed whether specific stimulation of this pathway could mitigate the disease. Using tissue from patients with Machado–Joseph disease, transgenic mice and a lentiviral-based rat model, we found an abnormal expression of endogenous autophagic markers, accumulation of autophagosomes and decreased levels of beclin-1, a crucial protein in the early nucleation step of autophagy. Lentiviral vector-mediated overexpression of beclin-1 led to stimulation of autophagic flux, mutant ataxin-3 clearance and overall neuroprotective effects in neuronal cultures and in a lentiviral-based rat model of Machado–Joseph disease. These data demonstrate that autophagy is a key degradation pathway, with beclin-1 playing a significant role in alleviating Machado–Joseph disease pathogenesis.
* Abbreviations
: Atg
: autophagic related protein
DARPP-32
: dopamine-and-cyclic AMP-regulated phosphoprotein of 32 kDa
p62
: sequestosome 1/p62 protein
TL;DR: It is shown that mice fed for 15 days with (–)‐epicatechin (present in dark chocolate) had improved exercise performance accompanied by an increased number of capillaries in the hindlimb muscle and an increased amount of muscle mitochondria as well as signalling for mitochondrial biogenesis, suggesting that (–).
Abstract: The flavanol (-)-epicatechin, a component of cacao (cocoa), has been shown to have multiple health benefits in humans. Using 1-year-old male mice, we examined the effects of 15 days of (-)-epicatechin treatment and regular exercise on: (1) exercise performance, (2) muscle fatigue, (3) capillarity, and (4) mitochondrial biogenesis in mouse hindlimb and heart muscles. Twenty-five male mice (C57BL/6N) were randomized into four groups: (1) water, (2) water-exercise (W-Ex), (3) (-)-epicatechin ((-)-Epi), and (4) (-)-epicatechin-exercise ((-)-Epi-Ex). Animals received 1 mg kg(-1) of (-)-epicatechin or water (vehicle) via oral gavage (twice daily). Exercise groups underwent 15 days of treadmill exercise. Significant increases in treadmill performance (∼50%) and enhanced in situ muscle fatigue resistance (∼30%) were observed with (-)-epicatechin. Components of oxidative phosphorylation complexes, mitofilin, porin, nNOS, p-nNOS, and Tfam as well as mitochondrial volume and cristae abundance were significantly higher with (-)-epicatechin treatment for hindlimb and cardiac muscles than exercise alone. In addition, there were significant increases in skeletal muscle capillarity. The combination of (-)-epicatechin and exercise resulted in further increases in oxidative phosphorylation-complex proteins, mitofilin, porin and capillarity than (-)-epicatechin alone. These findings indicate that (-)-epicatechin alone or in combination with exercise induces an integrated response that includes structural and metabolic changes in skeletal and cardiac muscles resulting in greater endurance capacity. These results, therefore, warrant the further evaluation of the underlying mechanism of action of (-)-epicatechin and its potential clinical application as an exercise mimetic.
TL;DR: The paper aims to review the major research achievements in the last decade, the current status, and the future directions of the BEM in the next decade.
Abstract: Sponsored by the U.S. National Science Foundation, a workshop on the boundary element method (BEM) was held on the campus of the University of Akron during September 1–3, 2010 (NSF, 2010, “Workshop on the Emerging Applications and Future Directions of the Boundary Element Method,” University of Akron, Ohio, September 1–3). This paper was prepared after this workshop by the organizers and participants based on the presentations and discussions at the workshop. The paper aims to review the major research achievements in the last decade, the current status, and the future directions of the BEM in the next decade. The review starts with a brief introduction to the BEM. Then, new developments in Green's functions, symmetric Galerkin formulations, boundary meshfree methods, and variationally based BEM formulations are reviewed. Next, fast solution methods for efficiently solving the BEM systems of equations, namely, the fast multipole method, the pre-corrected fast Fourier transformation method, and the adaptive cross approximation method are presented. Emerging applications of the BEM in solving microelectromechanical systems, composites, functionally graded materials, fracture mechanics, acoustic, elastic and electromagnetic waves, time-domain problems, and coupled methods are reviewed. Finally, future directions of the BEM as envisioned by the authors for the next five to ten years are discussed. This paper is intended for students, researchers, and engineers who are new in BEM research and wish to have an overview of the field. Technical details of the BEM and related approaches discussed in the review can be found in the Reference section with more than 400 papers cited in this review.
TL;DR: The establishment of cDNA libraries and comparative gene expression studies in pungent and non-pungent chili pepper fruits has identified candidate genes possibly involved in capsaicinoid biosynthesis.
Abstract: Capsicum species produce fruits that synthesize and accumulate unique hot compounds known as capsaicinoids in placental tissues The capsaicinoid biosynthetic pathway has been established, but the enzymes and genes participating in this process have not been extensively studied or characterized Capsaicinoids are synthesized through the convergence of two biosynthetic pathways: the phenylpropanoid and the branched-chain fatty acid pathways, which provide the precursors phenylalanine, and valine or leucine, respectively Capsaicinoid biosynthesis and accumulation is a genetically determined trait in chili pepper fruits as different cultivars or genotypes exhibit differences in pungency; furthermore, this characteristic is also developmentally and environmentally regulated The establishment of cDNA libraries and comparative gene expression studies in pungent and non-pungent chili pepper fruits has identified candidate genes possibly involved in capsaicinoid biosynthesis Genetic and molecular approaches have also contributed to the knowledge of this biosynthetic pathway; however, more studies are necessary for a better understanding of the regulatory process that accounts for different accumulation levels of capsaicinoids in chili pepper fruits
TL;DR: ICARUS T600 as mentioned in this paper is the first large mass (760 tons) example of a new generation of detectors able to combine the imaging capabilities of the old famous ''bubble chamber'' with the excellent energy measurement of huge electronic detectors.
Abstract: Important open questions are still present in fundamental Physics and Cosmology, like the nature of Dark Matter, the matter-antimatter asymmetry and the validity of the Standard Model of particle interactions. Addressing these questions requires a new generation of massive particle detectors to explore the subatomic and astrophysical worlds. ICARUS T600 is the first large mass (760 tons) example of a new generation of detectors able to combine the imaging capabilities of the old famous ``bubble chamber'' with the excellent energy measurement of huge electronic detectors. ICARUS T600 now operates at the Gran Sasso underground laboratory and is used to study cosmic rays, neutrino oscillations and the proton decay. The potential for doing physics of this novel telescope is presented through a few examples of neutrino interactions reconstructed with unprecedented detail. Detector design and early operation are also reported.