Institution
Instituto Politécnico Nacional
Education•Mexico City, Mexico•
About: Instituto Politécnico Nacional is a education organization based out in Mexico City, Mexico. It is known for research contribution in the topics: Population & Control theory. The organization has 43351 authors who have published 63315 publications receiving 938532 citations. The organization is also known as: Instituto Politécnico Nacional & Instituto Politecnico Nacional.
Topics: Population, Control theory, Thin film, Catalysis, Nonlinear system
Papers published on a yearly basis
Papers
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TL;DR: A high number of medications tested in preclinical models of endometriosis due to their theoretic capacity of disrupting important pathophysiologic pathways of the disease, such as inflammatory response, angiogenesis and cell survival, proliferation, migration, adhesion, and invasion were effective.
141 citations
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TL;DR: A review provides a summary of tetracycline's multiple mechanisms of action as a means to understand their beneficial effects, including their ability to act as reactive oxygen species scavengers and anti-inflammatory agents.
140 citations
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29 Aug 2017TL;DR: This study demonstrates how bioinformatics tools, such as metagenome functional prediction from 16S rRNA genes, can help understand biological systems and reveal microbial interactions in controlled systems (e.g., bioreactors) and uncovered butyrate-producing microbial communities and possible metabolic routes in a controlled fermentation system aimed atbutyrate production.
Abstract: Butyrate is a common fatty acid produced in important fermentative systems, such as the human/animal gut and other H 2 production systems. Despite its importance, there is little information on the partnerships between butyrate producers and other bacteria. The objective of this work was to uncover butyrate-producing microbial communities and possible metabolic routes in a controlled fermentation system aimed at butyrate production. The butyrogenic reactor was operated at 37°C and pH 5.5 with a hydraulic retention time of 31 h and a low hydrogen partial pressure (PH 2 ). High-throughput sequencing and metagenome functional prediction from 16S rRNA data showed that butyrate production pathways and microbial communities were different during batch (closed) and continuous-mode operation. Lactobacillaceae , Lachnospiraceae , and Enterococcaceae were the most abundant phylotypes in the closed system without PH 2 control, whereas Prevotellaceae , Ruminococcaceae , and Actinomycetaceae were the most abundant phylotypes under continuous operation at low PH 2 . Putative butyrate producers identified in our system were from Prevotellaceae , Clostridiaceae , Ruminococcaceae , and Lactobacillaceae . Metagenome prediction analysis suggests that nonbutyrogenic microorganisms influenced butyrate production by generating butyrate precursors such as acetate, lactate, and succinate. 16S rRNA gene analysis suggested that, in the reactor, a partnership between identified butyrogenic microorganisms and succinate (i.e., Actinomycetaceae ), acetate (i.e., Ruminococcaceae and Actinomycetaceae ), and lactate producers (i.e., Ruminococcaceae and Lactobacillaceae ) took place under continuous-flow operation at low PH 2 . IMPORTANCE This study demonstrates how bioinformatics tools, such as metagenome functional prediction from 16S rRNA genes, can help understand biological systems and reveal microbial interactions in controlled systems (e.g., bioreactors). Results obtained from controlled systems are easier to interpret than those from human/animal studies because observed changes may be specifically attributed to the design conditions imposed on the system. Bioinformatics analysis allowed us to identify potential butyrogenic phylotypes and associated butyrate metabolism pathways when we systematically varied the PH 2 in a carefully controlled fermentation system. Our insights may be adapted to butyrate production studies in biohydrogen systems and gut models, since butyrate is a main product and a crucial fatty acid in human/animal colon health.
140 citations
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University of Eastern Piedmont1, Ljubljana University Medical Centre2, University of Bristol3, Medical University of Silesia4, University Hospital of Wales5, Medisch Spectrum Twente6, Helsinki University Central Hospital7, Masaryk University8, Instituto Politécnico Nacional9, John Radcliffe Hospital10, Charles University in Prague11, Ludwig Maximilian University of Munich12, Academy for Urban School Leadership13, Medical University of Łódź14, French Institute of Health and Medical Research15, Hospital Universitario de Canarias16, Oulu University Hospital17, Turku University Hospital18, Aix-Marseille University19, Saarland University20, University of Padua21, Jagiellonian University Medical College22
TL;DR: The COVID-19 pandemic had significant impact on the treatment of patients with STEMI, with a 19% reduction in PPCI procedures, especially among patients suffering from hypertension, and a longer delay to treatment, which may have contributed to the increased mortality during the pandemic.
140 citations
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TL;DR: The results indicate that P. interruptus does not maintain a single homogenous population, despite extreme dispersal potential, and contribute to a growing number of studies showing that low FST and high family structure across populations can coexist, illuminating the foundations of cryptic genetic patterns and the nature of marine dispersal.
Abstract: We combine kinship estimates with traditional F-statistics to explain contemporary drivers of population genetic differentiation despite high gene flow. We investigate range-wide population genetic structure of the California spiny (or red rock) lobster (Panulirus interruptus) and find slight, but significant global population differentiation in mtDNA (ΦST = 0.006, P = 0.001; Dest_Chao = 0.025) and seven nuclear microsatellites (FST = 0.004, P < 0.001; Dest_Chao = 0.03), despite the species’ 240- to 330-day pelagic larval duration. Significant population structure does not correlate with distance between sampling locations, and pairwise FST between adjacent sites often exceeds that among geographically distant locations. This result would typically be interpreted as unexplainable, chaotic genetic patchiness. However, kinship levels differ significantly among sites (pseudo-F16,988 = 1.39, P = 0.001), and ten of 17 sample sites have significantly greater numbers of kin than expected by chance (P < 0.05). Moreover, a higher proportion of kin within sites strongly correlates with greater genetic differentiation among sites (Dest_Chao, R2 = 0.66, P < 0.005). Sites with elevated mean kinship were geographically proximate to regions of high upwelling intensity (R2 = 0.41, P = 0.0009). These results indicate that P. interruptus does not maintain a single homogenous population, despite extreme dispersal potential. Instead, these lobsters appear to either have substantial localized recruitment or maintain planktonic larval cohesiveness whereby siblings more likely settle together than disperse across sites. More broadly, our results contribute to a growing number of studies showing that low FST and high family structure across populations can coexist, illuminating the foundations of cryptic genetic patterns and the nature of marine dispersal.
140 citations
Authors
Showing all 43548 results
Name | H-index | Papers | Citations |
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Giacomo Bruno | 158 | 1687 | 124368 |
Giuseppe Mancia | 145 | 1369 | 139692 |
Giorgio Maggi | 135 | 1323 | 90270 |
Salvatore Nuzzo | 133 | 1533 | 91600 |
Giuseppe Iaselli | 133 | 1514 | 91558 |
Marcello Abbrescia | 132 | 1400 | 84486 |
Louis Antonelli | 132 | 1089 | 83916 |
Donato Creanza | 132 | 1452 | 89206 |
Alexis Pompili | 131 | 1437 | 86312 |
Gabriella Pugliese | 131 | 1309 | 88714 |
Giovanna Selvaggi | 131 | 1159 | 83274 |
Heriberto Castilla-Valdez | 130 | 1659 | 93912 |
Ricardo Lopez-Fernandez | 129 | 1213 | 81575 |
Cesare Calabria | 128 | 1095 | 76784 |
Paolo Vitulo | 128 | 1120 | 79498 |