Institution
Instituto Politécnico Nacional
Education•Mexico City, Mexico•
About: Instituto Politécnico Nacional is a education organization based out in Mexico City, Mexico. It is known for research contribution in the topics: Population & Context (language use). The organization has 43351 authors who have published 63315 publications receiving 938532 citations. The organization is also known as: Instituto Politécnico Nacional & Instituto Politecnico Nacional.
Topics: Population, Context (language use), Catalysis, Control theory, Thin film
Papers published on a yearly basis
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Nencki Institute of Experimental Biology1, Federal University of Rio de Janeiro2, Leibniz Institute for Neurobiology3, Fundación Instituto Leloir4, Pompeu Fabra University5, Virginia Commonwealth University6, Instituto Politécnico Nacional7, Florey Institute of Neuroscience and Mental Health8, Cross River University of Technology9, Hebrew University of Jerusalem10, Baylor College of Medicine11, University of Copenhagen12, University College London13, University of the Witwatersrand14, West Bengal University of Health Sciences15, University of Würzburg16, University of Connecticut Health Center17, University of Texas MD Anderson Cancer Center18
TL;DR: Basic concepts of synapse structure and function are discussed, and a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders as well as neurodegenerative disorders are provided.
Abstract: Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases. This notion has led to the concept of synaptopathies as brain diseases with synapse defects as shared pathogenic features. In this review, which was initiated at the 13th International Society for Neurochemistry Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer and Parkinson disease). We finally discuss the appropriateness and potential implications of gathering synapse diseases under a single term. Understanding common causes and intrinsic differences in disease-associated synaptic dysfunction could offer novel clues toward synapse-based therapeutic intervention for neurological and neuropsychiatric disorders. In this Review, which was initiated at the 13th International Society for Neurochemistry (ISN) Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer's and Parkinson's diseases), gathered together under the term of synaptopathies. Read the Editorial Highlight for this article on page 783.
230 citations
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TL;DR: This systematic review is to evaluate the consistency between definitions of DRE in the literature and the official definition in the International League Against Epilepsy guidelines, and to estimate the incidence, prevalence, and risk factors for DRE.
Abstract: Objective The definition of drug-resistant epilepsy (DRE) affects case identification and treatment, and impacts prevalence or incidence estimates and health burden estimation in epidemiology. The objective of this systematic review is to evaluate the consistency between definitions of DRE in the literature and the official definition in the International League Against Epilepsy (ILAE) guidelines, and to estimate the incidence, prevalence, and risk factors for DRE. Methods MEDLINE and EMBASE were searched for observational studies of DRE published between January 1980 and July 2015. The definitions of DRE in these studies were compared with the definition in the ILAE guidelines. Random-effect model meta-analyses were used to generate pooled estimates of prevalence or incidence and pooled odds ratios of the association with risk factors. Results Thirty-five studies met inclusion criteria, including 13 080 epilepsy patients and 3941 patients with DRE. The definition of DRE varied widely across studies, with only 12% meeting the requirements of the ILAE definition. The pooled prevalence proportion of DRE among epilepsy patients was 0.30 (95% confidence interval [CI] 0.19-0.42), and the pooled incidence proportion was 0.15 (95% CI 0.11-0.19). Age at onset, symptomatic epilepsy, abnormal neuroimaging findings, abnormal electroencephalography results, history of mental retardation, neuropsychiatric disorders, febrile seizure, and status epilepticus increased risk for DRE. Significance There are limited high-quality data available on DRE. Lack of consistency in definitions limits the ability to obtain robust estimates on the burden of DRE. More data based on the ILAE definition from well-designed epidemiologic studies are needed to generate accurate and reliable results.
229 citations
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TL;DR: In this article, the authors present an overview on microalgae with particular emphasis as a source for energy (biofuel/electricity) and new materials and discuss the critical issues involved in production of micro algae and their use, future R&D to overcome these, including the work initiated by the Federal University of Parana, UFPR, in Brazil are discussed.
Abstract: Increasing energy demands, predicted fossil fuels shortage in the near future, and environmental concerns due to the production of greenhouse gas carbon dioxide on their combustion have motivated the search for alternative ‘clean’ energy sources. Among many resources for this, microalgae have been found to be most promising due to their high production capacity of vegetable oils. They possess a high growth rate, need abundantly available solar light and CO2, and thus are more photosynthetically efficient than oil crops. Also, they tolerate high concentration of salts allowing the use of any type of water for the agriculture and the possibility of production using innovative compact photobioreactors. In addition, microalgae are a potential source of biomass, which may have great biodiversity and consequent variability in their biochemical composition. This paper presents an overview on microalgae with particular emphasis as a source for energy (biofuel/electricity) and new materials. Critical issues involved in production of microalgae and their use, future R & D to overcome these, including the work initiated by the authors at Federal University of Parana, UFPR, in Brazil are discussed. Copyright © 2010 John Wiley & Sons, Ltd.
229 citations
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TL;DR: Integrating conventional parameters and gene mutations significantly improves risk stratification of CMML patients, providing a robust basis for clinical decision-making and a reliable tool for clinical trials.
229 citations
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Michigan State University1, National Autonomous University of Mexico2, Universidad Michoacana de San Nicolás de Hidalgo3, Michigan Technological University4, University of Utah5, University of Maryland, College Park6, Polytechnic University of Puerto Rico7, University of Wisconsin-Madison8, National Institute of Astrophysics, Optics and Electronics9, Benemérita Universidad Autónoma de Puebla10, University of Guadalajara11, Pennsylvania State University12, Los Alamos National Laboratory13, George Mason University14, Colorado State University15, University of California, Irvine16, University of New Mexico17, Georgia Institute of Technology18, Instituto Politécnico Nacional19, Universidad Autónoma del Estado de Hidalgo20, University of New Hampshire21, University of California, Santa Cruz22, University of Alabama23, CINVESTAV24
TL;DR: The High Altitude Water Cherenkov (HAWC) observatory as mentioned in this paper is an array of large water-cherenkov detectors sensitive to gamma rays and hadronic cosmic rays in the energy band between 100 GeV and 100 TeV.
228 citations
Authors
Showing all 43548 results
Name | H-index | Papers | Citations |
---|---|---|---|
Giacomo Bruno | 158 | 1687 | 124368 |
Giuseppe Mancia | 145 | 1369 | 139692 |
Giorgio Maggi | 135 | 1323 | 90270 |
Salvatore Nuzzo | 133 | 1533 | 91600 |
Giuseppe Iaselli | 133 | 1514 | 91558 |
Marcello Abbrescia | 132 | 1400 | 84486 |
Louis Antonelli | 132 | 1089 | 83916 |
Donato Creanza | 132 | 1452 | 89206 |
Alexis Pompili | 131 | 1437 | 86312 |
Gabriella Pugliese | 131 | 1309 | 88714 |
Giovanna Selvaggi | 131 | 1159 | 83274 |
Heriberto Castilla-Valdez | 130 | 1659 | 93912 |
Ricardo Lopez-Fernandez | 129 | 1213 | 81575 |
Cesare Calabria | 128 | 1095 | 76784 |
Paolo Vitulo | 128 | 1120 | 79498 |