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Showing papers by "Instituto Superior Técnico published in 2015"


Journal ArticleDOI
TL;DR: A range of mechanisms underpinning the resilience of ecosystem functions across three ecological scales are identified and biodiversity, encompassing variation from within species to across landscapes, may be crucial for the longer-term resilience ofcosystem functions and the services that they underpin.
Abstract: Accelerating rates of environmental change and the continued loss of global biodiversity threaten functions and services delivered by ecosystems. Much ecosystem monitoring and management is focused on the provision of ecosystem functions and services under current environmental conditions, yet this could lead to inappropriate management guidance and undervaluation of the importance of biodiversity. The maintenance of ecosystem functions and services under substantial predicted future environmental change (i.e., their ‘resilience’) is crucial. Here we identify a range of mechanisms underpinning the resilience of ecosystem functions across three ecological scales. Although potentially less important in the short term, biodiversity, encompassing variation from within species to across landscapes, may be crucial for the longer-term resilience of ecosystem functions and the services that they underpin.

871 citations


Journal ArticleDOI
TL;DR: In this article, the state-of-the-art multispectral pansharpening techniques for hyperspectral data were compared with some of the state of the art methods for multi-spectral panchambering.
Abstract: Pansharpening aims at fusing a panchromatic image with a multispectral one, to generate an image with the high spatial resolution of the former and the high spectral resolution of the latter. In the last decade, many algorithms have been presented in the literatures for pansharpening using multispectral data. With the increasing availability of hyperspectral systems, these methods are now being adapted to hyperspectral images. In this work, we compare new pansharpening techniques designed for hyperspectral data with some of the state-of-the-art methods for multispectral pansharpening, which have been adapted for hyperspectral data. Eleven methods from different classes (component substitution, multiresolution analysis, hybrid, Bayesian and matrix factorization) are analyzed. These methods are applied to three datasets and their effectiveness and robustness are evaluated with widely used performance indicators. In addition, all the pansharpening techniques considered in this paper have been implemented in a MATLAB toolbox that is made available to the community.

620 citations


Journal ArticleDOI
A. Aab1, P. Abreu2, Marco Aglietta3, Marco Aglietta4  +640 moreInstitutions (64)
TL;DR: The Pierre Auger Observatory as mentioned in this paper, the world's largest cosmic ray observatory, has been in successful operation since completion in 2008 and has recorded data from an exposure exceeding 40,000 km$^2$ sr yr.
Abstract: The Pierre Auger Observatory, located on a vast, high plain in western Argentina, is the world's largest cosmic ray observatory. The objectives of the Observatory are to probe the origin and characteristics of cosmic rays above $10^{17}$ eV and to study the interactions of these, the most energetic particles observed in nature. The Auger design features an array of 1660 water-Cherenkov particle detector stations spread over 3000 km$^2$ overlooked by 24 air fluorescence telescopes. In addition, three high elevation fluorescence telescopes overlook a 23.5 km$^2$, 61 detector infill array. The Observatory has been in successful operation since completion in 2008 and has recorded data from an exposure exceeding 40,000 km$^2$ sr yr. This paper describes the design and performance of the detectors, related subsystems and infrastructure that make up the Auger Observatory.

615 citations


Journal ArticleDOI
TL;DR: The parallel power computing of Graphics Computing Units (GPUs) is used to accelerate DualSPHysics by up to two orders of magnitude compared to the performance of the serial version.

550 citations


Journal ArticleDOI
TL;DR: This review provides for a concise overview of heterocyclic active compounds and families and their main applications in medicine, focusing on those suitable for cancer therapy while simultaneously addressing main biochemical modes of action, biological targets, structure-activity relationships as well as intrinsic limitation issues in the use of these compounds.
Abstract: The majority of heterocycle compounds and typically common heterocycle fragments present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility and unique physicochemical properties, have poised them as true cornerstones of medicinal chemistry. Apart from the already marketed drugs, there are many other being investigated for their promising activity against several malignancies. In particular, anticancer research has been capitalizing on the intrinsic versatility and dynamic core scaffold of these compounds. Nevertheless, as for any other promising anticancer drugs, heterocyclic compounds do not come without shortcomings. In this review, we provide for a concise overview of heterocyclic active compounds and families and their main applications in medicine. We shall focus on those suitable for cancer therapy while simultaneously addressing main biochemical modes of action, biological targets, structure-activity relationships as well as intrinsic limitation issues in the use of these compounds. Finally, considering the advent of nanotechnology for effective selective targeting of drugs, we shall discuss fundamental aspects and considerations on nanovectorization of such compounds that may improve pharmacokinetic/pharmacodynamic properties of heterocycles.

399 citations


Journal ArticleDOI
TL;DR: In this article, the effects of permafrost thaw on lakes and streams in the Arctic were explored, where the authors explored the effect of both thermokarst (thawing and collapse of ice-rich permaculture) and deepening of the active layer (the surface soil layer that thaws and refreezes each year).
Abstract: . The Arctic is a water-rich region, with freshwater systems covering about 16 % of the northern permafrost landscape. Permafrost thaw creates new freshwater ecosystems, while at the same time modifying the existing lakes, streams, and rivers that are impacted by thaw. Here, we describe the current state of knowledge regarding how permafrost thaw affects lentic (still) and lotic (moving) systems, exploring the effects of both thermokarst (thawing and collapse of ice-rich permafrost) and deepening of the active layer (the surface soil layer that thaws and refreezes each year). Within thermokarst, we further differentiate between the effects of thermokarst in lowland areas vs. that on hillslopes. For almost all of the processes that we explore, the effects of thaw vary regionally, and between lake and stream systems. Much of this regional variation is caused by differences in ground ice content, topography, soil type, and permafrost coverage. Together, these modifying factors determine (i) the degree to which permafrost thaw manifests as thermokarst, (ii) whether thermokarst leads to slumping or the formation of thermokarst lakes, and (iii) the manner in which constituent delivery to freshwater systems is altered by thaw. Differences in thaw-enabled constituent delivery can be considerable, with these modifying factors determining, for example, the balance between delivery of particulate vs. dissolved constituents, and inorganic vs. organic materials. Changes in the composition of thaw-impacted waters, coupled with changes in lake morphology, can strongly affect the physical and optical properties of thermokarst lakes. The ecology of thaw-impacted lakes and streams is also likely to change; these systems have unique microbiological communities, and show differences in respiration, primary production, and food web structure that are largely driven by differences in sediment, dissolved organic matter, and nutrient delivery. The degree to which thaw enables the delivery of dissolved vs. particulate organic matter, coupled with the composition of that organic matter and the morphology and stratification characteristics of recipient systems will play an important role in determining the balance between the release of organic matter as greenhouse gases (CO2 and CH4), its burial in sediments, and its loss downstream. The magnitude of thaw impacts on northern aquatic ecosystems is increasing, as is the prevalence of thaw-impacted lakes and streams. There is therefore an urgent need to quantify how permafrost thaw is affecting aquatic ecosystems across diverse Arctic landscapes, and the implications of this change for further climate warming.

381 citations


Journal ArticleDOI
TL;DR: This work reviews the medicinal applications proposed for vanadium compounds with particular emphasis on the more recent publications and concludes that the potential ofVanadium compounds to treat type 2 diabetes is still an open question and therapies using vanadium compound for e.g. antitumor and anti-parasitic related diseases remain promising.

373 citations


Journal ArticleDOI
TL;DR: In this paper, the authors present a framework for forecasting cosmological constraints from future neutral hydrogen intensity mapping experiments at low to intermediate redshifts, and establish a simple way of comparing such surveys with optical galaxy redshift surveys.
Abstract: We present a framework for forecasting cosmological constraints from future neutral hydrogen intensity mapping experiments at low to intermediate redshifts. In the process, we establish a simple way of comparing such surveys with optical galaxy redshift surveys. We explore a wide range of experimental configurations and assess how well a number of cosmological observables (the expansion rate, growth rate, and angular diameter distance) and parameters (the densities of dark energy and dark matter, spatial curvature, the dark energy equation of state, etc.) will be measured by an extensive roster of upcoming experiments. A number of potential contaminants and systematic effects are also studied in detail. The overall picture is encouraging?if autocorrelation calibration can be controlled to a sufficient level, Phase I of the Square Kilometre Array should be able to constrain the dark energy equation of state about as well as a DETF Stage IV galaxy redshift survey like Euclid, in roughly the same time frame.

347 citations


Journal ArticleDOI
TL;DR: In this paper, the authors analyzed the mechanical performance of concrete with recycled aggregates from construction and demolition waste (CDW) from various locations in Portugal and concluded that the use of RA worsens most of the properties tested, especially when fine RA are used.

318 citations


Journal ArticleDOI
TL;DR: A survey on MDE is presented based on a unified conceptual model that clearly identifies and relates these essential concepts, namely the concepts of system, model, metamodel, modeling language, transformations, software platform, and software product.

318 citations


Journal ArticleDOI
TL;DR: It is shown that, by using a compact laser-driven setup, ion-free electron–positron plasmas with unique characteristics can be produced, and their charge neutrality, high-density and small divergence finally open up the possibility of studying electron– Positron Plasmas in controlled laboratory experiments.
Abstract: Electron-positron pair plasmas represent a unique state of matter, whereby there exists an intrinsic and complete symmetry between negatively charged (matter) and positively charged (antimatter) particles. These plasmas play a fundamental role in the dynamics of ultra-massive astrophysical objects and are believed to be associated with the emission of ultra-bright gamma-ray bursts. Despite extensive theoretical modelling, our knowledge of this state of matter is still speculative, owing to the extreme difficulty in recreating neutral matter-antimatter plasmas in the laboratory. Here we show that, by using a compact laser-driven setup, ion-free electron-positron plasmas with unique characteristics can be produced. Their charge neutrality (same amount of matter and antimatter), high-density and small divergence finally open up the possibility of studying electron-positron plasmas in controlled laboratory experiments.

Journal ArticleDOI
TL;DR: In this article, the authors present a survey on the development and use of Artificial Neural Network (ANN) models in structural reliability analysis, identifying the different types of ANNs, the methods of structural reliability assessment that are typically used, the techniques proposed for ANN training set improvement and also some applications of ANN approximations to structural design and optimization problems.

Journal ArticleDOI
TL;DR: In this article, the authors analyzed the durability performance of concrete with recycled aggregates (RA) from construction and demolition waste (CDW) from various locations in Portugal and concluded that the use of RA is highly detrimental.

Journal ArticleDOI
TL;DR: In this paper, the effect of incorporating recycled aggregates, sourced from construction and demolition waste, on the carbonation behavior of concrete is reviewed and a statistical analysis is presented on the effect that introducing increasing amounts of recycled aggregate concrete on carbonation depth and coefficient of accelerated carbonation is presented.
Abstract: This paper reviews the effect of incorporating recycled aggregates, sourced from construction and demolition waste, on the carbonation behaviour of concrete. It identifies various influencing aspects related to the use of recycled aggregates, such as replacement level, size and origin, as well as the influence of curing conditions, use of chemical admixtures and additions, on carbonation over a long period of time. A statistical analysis on the effect of introducing increasing amounts of recycled aggregates on the carbonation depth and coefficient of accelerated carbonation is presented. This paper also presents the use of existing methodologies to estimate the required accelerated carbonation resistance of a reinforced recycled aggregate concrete exposed to natural carbonation conditions with the use of accelerated carbonation tests. Results show clear increasing carbonation depths with increasing replacement levels when recycled aggregate concrete mixes are made with a similar mix design to that of the control natural aggregate concrete. The relationship between the compressive strength and coefficients of accelerated carbonation is similar between the control concrete and the recycled aggregate concrete mixes.

Journal ArticleDOI
TL;DR: In this paper, a systematic review of 119 publications, selected from 235, published over a period of 36 years from 1978 to 2014, relating to the effect on concrete compressive strength of the various aspects related to the use of recycled aggregates (RA) such as replacement level, size, origin, moisture content, exposure of the resulting concrete to different environmental conditions, use of chemical admixtures and additions, and strength development over time.
Abstract: This paper provides a systematic review of 119 publications, selected from 235, published over a period of 36 years from 1978 to 2014, relating to the effect on concrete compressive strength of the various aspects related to the use of recycled aggregates (RA) such as replacement level, size, origin, moisture content, exposure of the resulting concrete to different environmental conditions, use of chemical admixtures and additions, and strength development over time The data were collectively subjected to a statistical analysis, the results of which allowed producing a model for predicting concrete strength, based on the quality and content of the RA

Journal ArticleDOI
A. Aab1, P. Abreu2, Marco Aglietta3, Eun-Joo Ahn4  +490 moreInstitutions (65)
TL;DR: Al Almela, Daniel Alejandro as discussed by the authors, Federación Nacional de Investigaciones Cientificas y Tecnicas (FNCIT) and CONGESTO NACIONAL de Investigación Científicas (CICIT) of Argentina.
Abstract: Fil: Almela, Daniel Alejandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Parque Centenario. Instituto de Tecnologias en Deteccion y Astroparticulas; Argentina

Journal ArticleDOI
TL;DR: In this paper, a detailed mechanism of the pathways involved in CO 2 methanation over NiUSY catalysts is discussed in accordance with infrared spectroscopic data. Ni-impregnated USY zeolites with increasing Ni content (5, 10, 14% wt. ) were investigated by operando IR spectroscopy for both CO 2 adsorption and CO 2 meetinghanation conditions reaction.
Abstract: Ni-impregnated USY zeolites with increasing Ni content (5, 10, 14% wt. ) were investigated by operando IR spectroscopy for both CO 2 adsorption and CO 2 methanation conditions reaction. In-situ FTIR and TPD experiments highlighted a rather weak CO 2 adsorption, which occurs namely as carbonates or CO 2 linear complexes over cations ( e . g. , Na + ). Under methanation conditions, dissociated hydrogen reacts with carbonates and/or physisorbed CO 2 , leading to monodentate formates, then carbonyls (both adsorbed onto Ni 0 particles), and finally to methane. A detailed mechanism of the pathways involved in CO 2 methanation over NiUSY catalysts is then discussed in accordance with infrared spectroscopic data.

Journal ArticleDOI
TL;DR: PEDOT PSS was, for the first time, used to elongate human NSC through the application of pulsed current, impacting on their differentiation towards neurons and contributing to longer neurites.

Journal ArticleDOI
TL;DR: In this article, the main types of both homogeneous and supported vanadium catalysts and the most efficient catalytic systems in different reactions are presented and compared, and the proposed mechanisms of various catalytic oxidation processes are also outlined.

Journal ArticleDOI
TL;DR: In this article, a quasi-adiabatic, fully-relativistic analysis of the evolution of the superradiant instabilities of spinning black holes (BHs) is presented.
Abstract: Superradiant instabilities of spinning black holes (BHs) can be used to impose strong constraints on ultralight bosons, thus turning BHs into effective particle detectors. However, very little is known about the development of the instability and whether its nonlinear time evolution accords to the linear intuition. For the first time, we attack this problem by studying the impact of gravitational-wave (GW) emission and gas accretion on the evolution of the instability. Our quasi-adiabatic, fully-relativistic analysis shows that: (i) GW emission does not have a significant effect on the evolution of the BH, (ii) accretion plays an important role, and (iii) although the mass of the scalar cloud developed through superradiance can be a sizeable fraction of the BH mass, its energy-density is very low and backreaction is negligible. Thus, massive BHs are well described by the Kerr geometry even if they develop bosonic clouds through superradiance. Using Monte Carlo methods and very conservative assumptions, we provide strong support to the validity of the linearized analysis and to the bounds of previous studies.

Journal ArticleDOI
TL;DR: The results show that color constancy improves the classification of multisource images, increasing the sensitivity of a bag-of-features system from 71.0% to 79.7% and the specificity from 55.2% to 76% using only 1-D RGB histograms as features.
Abstract: Robustness is one of the most important characteristics of computer-aided diagnosis systems designed for dermoscopy images. However, it is difficult to ensure this characteristic if the systems operate with multisource images acquired under different setups. Changes in the illumination and acquisition devices alter the color of images and often reduce the performance of the systems. Thus, it is important to normalize the colors of dermoscopy images before training and testing any system. In this paper, we investigate four color constancy algorithms: Gray World, max-RGB, Shades of Gray, and General Gray World. Our results show that color constancy improves the classification of multisource images, increasing the sensitivity of a bag-of-features system from 71.0% to 79.7% and the specificity from 55.2% to 76% using only 1-D RGB histograms as features.

Journal ArticleDOI
TL;DR: A ratiometric fluorescent nanoprobe based on terbium functionalized carbon dots was designed to detect dipicolinic acid (DPA) as an anthrax biomarker with high selectivity and sensitivity.

Journal ArticleDOI
TL;DR: In this paper, the authors present a comparative study on the most relevant existing viscoelastic contact force models for simple solid impact problems with the sole purpose of comparing the performance of the various models and examining the corresponding system behavior.

Journal ArticleDOI
TL;DR: In this paper, the physical, chemical and mineralogical characteristics of fine recycled aggregates obtained from crushed concrete waste, comparing them with two types of natural fine aggregates from different origins, are assessed.

Journal ArticleDOI
TL;DR: In this article, a case study of students who enrolled in more than one program in environmental and/or sustainability science (bachelor, master, and doctorate), offered by Universidade Aberta, the Portuguese Distance Learning University, was analyzed.

Journal ArticleDOI
TL;DR: In this paper, a systematic literature review is provided, based on the identification, appraisal, selection and synthesis of publications relating to the effect of incorporating recycled aggregates, sourced from construction and demolition wastes, on the tensile strength of concrete.

Journal ArticleDOI
TL;DR: The aims of the benchmark are to assess the dispersion of results on the same simulation study cases, to demonstrate the accuracy of numerical methodologies and simulation models and to identify the best suited modelling approaches to study pantograph–catenary interaction.
Abstract: This paper describes the results of a voluntary benchmark initiative concerning the simulation of pantograph-catenary interaction, which was proposed and coordinated by Politecnico di Milano and pa ...

Journal ArticleDOI
TL;DR: The ability of vanadium to interfere with the metabolic processes involving Ca2+ and Mg2+, connected with its versatility to undergo changes in coordination geometry, allow V to influence the function of a large variety of phosphate-metabolizing enzymes and vanadate(V) salts and compounds have been frequently used either as inhibitors of these enzymes, or as probes to study the mechanisms of their reactions and catalytic cycle.

Journal ArticleDOI
TL;DR: In this paper, the authors compare evolutionary predictions of double compact object merger rate densities with initial and forthcoming LIGO/Virgo upper limits, and find that due to the cosmological reach of advanced detectors, current conversion methods of population synthesis predictions into merger rates are insufficient.
Abstract: We compare evolutionary predictions of double compact object merger rate densities with initial and forthcoming LIGO/Virgo upper limits. We find that: (i) Due to the cosmological reach of advanced detectors, current conversion methods of population synthesis predictions into merger rate densities are insufficient. (ii) Our optimistic models are a factor of 18 below the initial LIGO/Virgo upper limits for BH-BH systems, indicating that a modest increase in observational sensitivity (by a factor of 2.5) may bring the first detections or first gravitational wave constraints on binary evolution. (iii) Stellar-origin massive BH-BH mergers should dominate event rates in advanced LIGO/Virgo and can be detected out to redshift z=2 with templates including inspiral, merger, and ringdown. Normal stars (<150 Msun) can produce such mergers with total redshifted mass up to 400 Msun. (iv) High black hole natal kicks can severely limit the formation of massive BH-BH systems (both in isolated binary and in dynamical dense cluster evolution), and thus would eliminate detection of these systems even at full advanced LIGO/Virgo sensitivity. We find that low and high black hole natal kicks are allowed by current observational electromagnetic constraints. (v) The majority of our models yield detections of all types of mergers (NS-NS, BH-NS, BH-BH) with advanced detectors. Numerous massive BH-BH merger detections will indicate small (if any) natal kicks for massive BHs.

Journal ArticleDOI
Georges Aad1, Brad Abbott2, Jalal Abdallah3, S. Abdel Khalek4  +2810 moreInstitutions (209)
TL;DR: In this article, a search for a heavy, CP-odd Higgs boson decaying into a Z boson and a 125 GeV h, with the ATLAS detector at the LHC is presented.