Instituto Superior Técnico

About: Instituto Superior Técnico is a based out in . It is known for research contribution in the topics: Catalysis & Finite element method. The organization has 10085 authors who have published 30226 publications receiving 667524 citations. The organization is also known as: IST & Instituto Superior Tecnico.

Study of the rare decays of B s 0 and B 0 mesons into muon pairs using data collected during 2015 and 2016 with the ATLAS detector

Abstract: A study of the decays B0 s ! + and B0 ! + has been performed using 26 : 3 fb of 13TeV LHC proton-proton collision data collected with the ATLAS detector in 2015 and 2016. Since the detector resolut ...

DNA adducts derived from administration of acrylamide and glycidamide to mice and rats.

Abstract: Acrylamide (AA) is an important industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in chronic rodent bioassays. Recent findings of AA in many common starchy foods have sparked renewed interest in determining toxic mechanisms and in understanding the cancer, neurotoxicity, and reproductive risks from typical human exposures. Dosing mice and rats with AA (50 mg/kg) led to presence of glycidamide (GA) in serum and tissues. Furthermore, GA-derived DNA adducts of adenine and guanine were formed in all tissues examined, including both target tissues identified in rodent carcinogenicity bioassays and in non-target tissues. Dosing rats and mice with an equimolar amount of GA typically produced higher levels of DNA adducts than observed with AA. Kinetics of DNA adduct formation and accumulation were measured following oral administration of a single dose of AA (50 mg/kg) or from repeat dosing (1 mg/kg/day), respectively. The formation of these DNA adducts is consistent with previously reported mutagenicity of AA and GA in vitro, which involved reaction of GA with adenine and guanine bases. These results provide strong support for a genotoxic mechanism of AA carcinogenicity in rodents. The kinetic/biomarker approaches described here may represent a meaningful way to extrapolate cancer risks to actual human exposures from food, which are much lower.

Coherent structures in unsteady swirling jet flow

Abstract: An LDA technique and phase-averaging analysis were used to study unsteady precessing flow in a model vortex burner. Detailed measurements were made for Re=15,000 and S=1.01. On the basis of the analysis of phase-averaged data and vortex detection by the λ2-technique of Joeng and Hussain (1995), three precessing spiral vortex structures were identified: primary vortex (PV), inner secondary vortex (ISV), and outer secondary vortex (OSV). The PV is the primary and most powerful structure as it includes primary vorticity generated by the swirler; the ISV and OSV are considered here as secondary vortical structures. The jet breakdown zone is the conjunction of a pair of co-rotating co-winding spiral vortices, PV and ISV. The interesting new feature described is that the secondary vortices form a three-dimensional vortex dipole with a helical geometry. The effect of coupling of secondary vortices was suggested as a mechanism of enhanced stability reflected in their increased axial extent.