Instituto Superior Técnico

About: Instituto Superior Técnico is a based out in . It is known for research contribution in the topics: Catalysis & Finite element method. The organization has 10085 authors who have published 30226 publications receiving 667524 citations. The organization is also known as: IST & Instituto Superior Tecnico.

Lipopolysaccharide modification in Gram-negative bacteria during chronic infection

Abstract: The Gram-negative bacterial lipopolysaccharide (LPS) is a major component of the outer membrane that plays a key role in host-pathogen interactions with the innate immune system. During infection, bacteria are exposed to a host environment that is typically dominated by inflammatory cells and soluble factors, including antibiotics, which provide cues about regulation of gene expression. Bacterial adaptive changes including modulation of LPS synthesis and structure are a conserved theme in infections, irrespective of the type or bacteria or the site of infection. In general, these changes result in immune system evasion, persisting inflammation and increased antimicrobial resistance. Here, we review the modifications of LPS structure and biosynthetic pathways that occur upon adaptation of model opportunistic pathogens (Pseudomonas aeruginosa, Burkholderia cepacia complex bacteria, Helicobacter pylori and Salmonella enterica) to chronic infection in respiratory and gastrointestinal sites. We also discuss the molecular mechanisms of these variations and their role in the host-pathogen interaction.

Rates and properties of type Ia supernovae as a function of mass and star-formation in their host galaxies

Abstract: (ABRIDGED) We show that Type Ia supernovae (SNe Ia) are formed within both very young and old stellar populations, with observed rates that depend on the stellar mass and mean star-formation rates (SFRs) of their host galaxies. Models where the SN Ia rate depends solely on host galaxy stellar mass are ruled out with 99% confidence. Our analysis is based on 100 spectroscopically-confirmed SNe Ia, plus 24 photometrically-classified events, all from the Supernova Legacy Survey (SNLS) and distributed over 0.2

Sets of "non-typical" points have full topological entropy and full hausdorff dimension

Abstract: For subshifts of finite type, conformal repellers, and conformal horseshoes, we prove that the set of points where the pointwise dimensions, local entropies, Lyapunov exponents, and Birkhoff averages do not exist simultaneously, carries full topological entropy and full Hausdorff dimension. This follows from a much stronger statement formulated for a class of symbolic dynamical systems which includes subshifts with the specification property. Our proofs strongly rely on the multifractal analysis of dynamical systems and constitute a non-trivial mathematical application of this theory.