Institution
International Agency for Research on Cancer
Government•Lyon, France•
About: International Agency for Research on Cancer is a government organization based out in Lyon, France. It is known for research contribution in the topics: Population & Cancer. The organization has 2989 authors who have published 9010 publications receiving 929752 citations. The organization is also known as: IARC.
Topics: Population, Cancer, Breast cancer, Risk factor, European Prospective Investigation into Cancer and Nutrition
Papers published on a yearly basis
Papers
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TL;DR: The burden of esophageal cancer by histological subtype is expected to rise dramatically across high-income countries and has already or will surpass ESCC incidence in the coming years, especially among men.
277 citations
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TL;DR: A detailed banded chromosome analysis was performed in five established Ewing's sarcoma cell lines originating from four unrelated patients in relapse, suggesting that t(11;22)(q24;q12) is a chromosomal change specific to ES cells, in which the rearranged chromosome #22 could be the consistent karyotypic feature and the crucial step in terms of cell proliferation.
277 citations
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TL;DR: It is suggested that percentage dense area is a stronger breast cancer risk factor than absolute dense area, but it is unclear whether the association is independent ofabsolute dense area.
Abstract: Results Among premenopausal women (n = 1776 case patients; n = 2834 control subjects), summary odds ratios were 1.37 (95% CI = 1.29 to 1.47) for absolute dense area, 0.78 (95% CI = 0.71 to 0.86) for absolute nondense area, and 1.52 (95% CI = 1.39 to 1.66) for percentage dense area when pooling estimates adjusted for age, body mass index, and parity. Corresponding odds ratios among postmenopausal women (n = 6643 case patients; n = 11 187 control subjects) were 1.38 (95% CI = 1.31 to 1.44), 0.79 (95% CI = 0.73 to 0.85), and 1.53 (95% CI = 1.44 to 1.64). After additional adjustment for absolute dense area, associations between absolute nondense area and breast cancer became attenuated or null in several studies and summary odds ratios became 0.82 (95% CI = 0.71 to 0.94; Pheterogeneity = .02) for premenopausal and 0.85 (95% CI = 0.75 to 0.96; Pheterogeneity < .01) for postmenopausal women. Conclusions The results suggest that percentage dense area is a stronger breast cancer risk factor than absolute dense area. Absolute nondense area was inversely associated with breast cancer risk, but it is unclear whether the association is independent of absolute dense area.
274 citations
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TL;DR: Although germline APC mutations are a well established cause of familial colon and brain tumors (Turcot syndrome), this study provides the first evidence that APC mutation are also operative in a subset of sporadic medulloblastomas.
Abstract: The cerebellar medulloblastoma (WHO Grade IV) is a highly malignant, invasive embryonal tumor with preferential manifestation in children. Several molecular alterations appear to be involved, including isochromosome 17q and the p53, PTCH , and β-catenin gene mutations. In this study, 46 sporadic medulloblastomas were screened for the presence of mutations in genes of the Wnt signaling pathway ( APC and β-catenin). Single-strand conformational polymorphism (SSCP) analysis followed by direct DNA sequencing revealed 3 miscoding APC mutations in 2 (4.3%) medulloblastomas. One case contained a GCA→GTA mutation at codon 1296 (Ala→Val), and another case had double point mutations at codons 1472 (GTA→ATA, Val→Ile) and 1495 (AGT→GGT, Ser→Gly). Miscoding β-catenin mutations were detected in 4 tumors (8.7%). Three of these were located at codon 33 (TCT →TTT, Ser→Phe. and another at codon 37 (TCT→GCT, Ser→Ala). Adenomatous polyposis coli ( APC ) gene and β-catenin mutations were mutually exclusive and occurred in a total of 6 of 46 cases (13%). Although germline APC mutations are a well established cause of familial colon and brain tumors (Turcot syndrome), this study provides the first evidence that APC mutations are also operative in a subset of sporadic medulloblastomas.
274 citations
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International Agency for Research on Cancer1, University of Sydney2, Karolinska Institutet3, Cancer Council Victoria4, University of Leeds5, Tel Aviv University6, Sheba Medical Center7, University of Mainz8, University of Tampere9, Radiation and Nuclear Safety Authority10, Bielefeld University11, National Institute for Occupational Safety and Health12, University of Western Australia13, Claude Bernard University Lyon 114, Istituto Superiore di Sanità15, University of Ottawa16, Health Protection Agency17, University of British Columbia18, University of Nottingham19, Université du Québec20, Massey University21, German Cancer Research Center22, Université de Montréal23, Tokyo Metropolitan University24, Keio University25, National Institute of Occupational Health26, University of Auckland27
TL;DR: The INTERPHONE study is the largest case–control study to date investigating risks related to mobile phone use and to other potential risk factors for the tumours of interest and includes 2,765 glioma, 2,425 meningiomas, 1,121 acoustic neurinoma, 109 malignant parotid gland tumour cases and 7,658 controls.
Abstract: The very rapid worldwide increase in mobile phone use in the last decade has generated considerable interest in the possible health effects of exposure to radio frequency (RF) fields. A multinational case-control study, INTERPHONE, was set-up to investigate whether mobile phone use increases the risk of cancer and, more specifically, whether the RF fields emitted by mobile phones are carcinogenic. The study focused on tumours arising in the tissues most exposed to RF fields from mobile phones: glioma, meningioma, acoustic neurinoma and parotid gland tumours. In addition to a detailed history of mobile phone use, information was collected on a number of known and potential risk factors for these tumours. The study was conducted in 13 countries. Australia, Canada, Denmark, Finland, France, Germany, Israel, Italy, Japan, New Zealand, Norway, Sweden, and the UK using a common core protocol. This paper describes the study design and methods and the main characteristics of the study population. INTERPHONE is the largest case-control study to date investigating risks related to mobile phone use and to other potential risk factors for the tumours of interest and includes 2,765 glioma, 2,425 meningioma, 1,121 acoustic neurinoma, 109 malignant parotid gland tumour cases and 7,658 controls. Particular attention was paid to estimating the amount and direction of potential recall and participation biases and their impact on the study results.
274 citations
Authors
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Name | H-index | Papers | Citations |
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David J. Hunter | 213 | 1836 | 207050 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Elio Riboli | 158 | 1136 | 110499 |
Silvia Franceschi | 155 | 1340 | 112504 |
Stephen J. Chanock | 154 | 1220 | 119390 |
Paolo Boffetta | 148 | 1455 | 93876 |
Timothy J. Key | 146 | 808 | 90810 |
Hans-Olov Adami | 145 | 908 | 83473 |
Joseph J.Y. Sung | 142 | 1240 | 92035 |
Heiner Boeing | 140 | 1024 | 92580 |
Anne Tjønneland | 139 | 1345 | 91556 |
Kim Overvad | 139 | 1196 | 86018 |
Sheila Bingham | 136 | 519 | 67332 |
Pasi A. Jänne | 136 | 685 | 89488 |
Peter Kraft | 135 | 821 | 82116 |