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Institution

International Centre for Diarrhoeal Disease Research, Bangladesh

FacilityDhaka, Bangladesh
About: International Centre for Diarrhoeal Disease Research, Bangladesh is a facility organization based out in Dhaka, Bangladesh. It is known for research contribution in the topics: Population & Vibrio cholerae. The organization has 3103 authors who have published 5238 publications receiving 226880 citations. The organization is also known as: SEATO Cholera Research Laboratory & Bangladesh International Centre for Diarrhoeal Disease Research.


Papers
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Journal ArticleDOI
04 Jan 2016-Vaccine
TL;DR: It is demonstrated that a mobile phone intervention can improve vaccination coverage in rural hard-to-reach and urban street dweller communities in Bangladesh and should serve as an example to other low-income countries with high mobile phone usage.

98 citations

Journal ArticleDOI
21 Oct 2010-Nature
TL;DR: It is found that acquisition and chromosomal integration of the TLC-Knφ1 genome restored a perfect dif site and normal morphology to V. cholerae wild-type and mutant strains with dif− filamentation phenotypes.
Abstract: It has been known since the 1990s that the cholera toxin genes in Vibrio cholerae are found in the integrated bacteriophage CTXΦ, located in the V. cholerae genome adjacent to toxin-linked cryptic (TLC), a chromosomal DNA element of unknown function. TLC is now shown to correspond to the genome of TLCΦ, a satellite filamentous phage that uses the morphogenesis genes of a third filamentous phage (fs2Φ) to form infectious particles. By reconstructing the events that lead to the acquisition of phage DNA and comparing these to the genome of pandemic strains, Hassan et al. obtain a model of how virulent V. cholerae strains evolve to become successful human pathogens. Bacterial chromosomes often carry integrated genetic elements (such as plasmids and prophages) that contribute to the evolutionary fitness of the host bacterium. In Vibrio cholerae, a prophage encodes cholera toxin. Here, the events that led to the acquisition of phage DNA have been reconstructed, revealing the cooperative interactions between multiple filamentous phages that contributed to the emergence of virulent V. cholerae strains. Bacterial chromosomes often carry integrated genetic elements (for example plasmids, transposons, prophages and islands) whose precise function and contribution to the evolutionary fitness of the host bacterium are unknown. The CTXφ prophage, which encodes cholera toxin in Vibrio cholerae1, is known to be adjacent to a chromosomally integrated element of unknown function termed the toxin-linked cryptic (TLC)2. Here we report the characterization of a TLC-related element that corresponds to the genome of a satellite filamentous phage (TLC-Knφ1), which uses the morphogenesis genes of another filamentous phage (fs2φ) to form infectious TLC-Knφ1 phage particles. The TLC-Knφ1 phage genome carries a sequence similar to the dif recombination sequence, which functions in chromosome dimer resolution using XerC and XerD recombinases3. The dif sequence is also exploited by lysogenic filamentous phages (for example CTXφ) for chromosomal integration of their genomes. Bacterial cells defective in the dimer resolution often show an aberrant filamentous cell morphology3,4. We found that acquisition and chromosomal integration of the TLC-Knφ1 genome restored a perfect dif site and normal morphology to V. cholerae wild-type and mutant strains with dif− filamentation phenotypes. Furthermore, lysogeny of a dif− non-toxigenic V. cholerae with TLC-Knφ1 promoted its subsequent toxigenic conversion through integration of CTXφ into the restored dif site. These results reveal a remarkable level of cooperative interactions between multiple filamentous phages in the emergence of the bacterial pathogen that causes cholera.

98 citations

Journal ArticleDOI
TL;DR: There is an urgent need for Bangladesh to identify the arsenic (As) contaminated tubewells (TWs) in order to assess the health risks and initiate appropriate mitigation measures, and field test kits offer the only practical tool within the time frame and financial resources available for screening and assessment of the As contaminated TWs as well as their monitoring than that of the laboratory measurement.

98 citations

Journal ArticleDOI
TL;DR: It is confirmed that low socio-economic groups and poor hygiene and sanitation groups were most vulnerable to flood-related diarrhoea.
Abstract: This paper identifies groups vulnerable to the effect of flooding on hospital visits due to diarrhoea during and after a flood event in 1998 in Dhaka, Bangladesh. The number of observed cases of cholera and non-cholera diarrhoea per week was compared to expected normal numbers during the flood and post-flood periods, obtained as the season-specific average over the two preceding and subsequent years using Poisson generalised linear models. The expected number of diarrhoea cases was estimated in separate models for each category of potential modifying factors: sex, age, socio-economic status and hygiene and sanitation practices. During the flood, the number of cholera and non-cholera diarrhoea cases was almost six and two times higher than expected, respectively. In the post-flood period, the risk of non-cholera diarrhoea was significantly higher for those with lower educational level, living in a household with a nonconcrete roof, drinking tube-well water (vs. tap water), using a distant water source and unsanitary toilets. The risk for cholera was significantly higher for those drinking tube-well water and those using unsanitary toilets. This study confirms that low socio-economic groups and poor hygiene and sanitation groups were most vulnerable to flood-related diarrhoea.

98 citations

Journal ArticleDOI
TL;DR: It is suggested that household food security is a determinant of child growth in rural Bangladesh, and that it may be necessary to ensure food security of these poor rural households to prevent highly prevalent undernutrition in this population and in similar settings elsewhere in the world.
Abstract: Abstract Objective Despite a strong relationship between household food security and the health and nutritional status of adults and older children, the association of household food security with the growth of infants and young children has not been adequately studied, particularly in developing countries. We examined the association between household food security and subsequent growth of infants and young children in rural Bangladesh. Design We followed 1343 children from birth to 24 months of age who were born in the Maternal and Infant Nutrition Intervention in Matlab (MINIMat) study in rural Bangladesh. A food security scale was created from data collected on household food security from the mothers during pregnancy. Data on weight and length were collected monthly in the first year and quarterly in the second year of life. Anthropometric indices were calculated relative to the 2006 WHO child growth standards. Growth trajectories were modelled using multilevel models for change controlling for possible confounders. Results Household food security was associated (P < 0·05) with greater subsequent weight and length gain in this cohort. Attained weight, length and anthropometric indices from birth to 24 months were higher (P < 0·001) among those who were in food-secure households. Proportions of underweight and stunting were significantly (P < 0·05) lower in food-secure households. Conclusions These results suggest that household food security is a determinant of child growth in rural Bangladesh, and that it may be necessary to ensure food security of these poor rural households to prevent highly prevalent undernutrition in this population and in similar settings elsewhere in the world.

98 citations


Authors

Showing all 3121 results

NameH-indexPapersCitations
Stanley Falkow13434962461
Myron M. Levine12378960865
Roger I. Glass11647449151
Robert F. Breiman10547343927
Harry B. Greenberg10043334941
Barbara J. Stoll10039042107
Andrew M. Prentice9955046628
Robert H. Gilman9690343750
Robert E. Black9220156887
Johan Ärnlöv9138690490
Juan Jesus Carrero8952266970
John D. Clemens8950628981
William A. Petri8550726906
Toshifumi Hibi8280828674
David A. Sack8043723320
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20235
202234
2021494
2020414
2019391
2018334