Institution
International Centre for Diarrhoeal Disease Research, Bangladesh
Facility•Dhaka, Bangladesh•
About: International Centre for Diarrhoeal Disease Research, Bangladesh is a facility organization based out in Dhaka, Bangladesh. It is known for research contribution in the topics: Population & Vibrio cholerae. The organization has 3103 authors who have published 5238 publications receiving 226880 citations. The organization is also known as: SEATO Cholera Research Laboratory & Bangladesh International Centre for Diarrhoeal Disease Research.
Topics: Population, Vibrio cholerae, Cholera, Diarrhea, Health care
Papers published on a yearly basis
Papers
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TL;DR: It is concluded that sialylation of C. jejuni LOS is not only a risk factor for development of post-infectious symptoms, but is also associated with increased severity of enteric disease.
93 citations
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TL;DR: Although the first introduction of G9 isolates in the Belgian population was recorded in 1997, G9 strains were able to establish themselves quickly as the predominant genotype, indicating the urgent consideration of the G9 moiety in rotavirus vaccines.
93 citations
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TL;DR: E. histolytica infection was prevalent in this population, with most infections asymptomatic and diarrhea associated with both the amount of parasite and the composition of the microbiota, and a high parasite burden and expansion of the Prevotella copri level was associated with diarrhea.
Abstract: Children in developing countries are continually exposed to enteric pathogens [1–4]. This results in high rates of morbidity and mortality, especially in infants [5]. The outcome of an Entamoeba histolytica exposure can be diarrhea, dysentery, or amebic liver abscess, with the latter occurring mainly in men [6]. Disease, however, occurs in a minority of E. histolytica infections (approximately 20%) [6]. While both host and parasite factors contribute to outcome, they do not entirely explain susceptibility [7–9].
A prospective longitudinal study of enteric pathogens in a slum community in Dhaka, Bangladesh, has provided a rich data set to identify parameters important for protection and disease. It has been previously shown that children in this study cohort who are malnourished at birth are more susceptible to amebiasis and in general experience more-severe diarrhea [2]. There is evidence in support of both passive and active acquired immunity. Infants with mothers with high levels of breast milk anti-galactose/N-acetylgalactosamine (Gal/GalNAc) lectin immunoglobulin A (IgA) had fewer E. histolytica infections, and children with fecal IgA anti-Gal/GalNAc lectin IgA also had a lower incidence of new infection [10, 11].
Weaning and the introduction of supplementary food into the diet is known to trigger changes in the bacterial composition of the microbiome that include increases in Prevotellaceae and Bacteroides species [12, 13]. The first 2 years of life in general is a period of rapid immune and microbiome maturation, which, in this population, may be disrupted by malnutrition and environmental insult [13–15].
Here we describe the natural history of amebiasis in the first 2 years of life in infants from an urban slum in Dhaka. The cumulative incidence of amebic infection and diarrhea, the association of protection with anti-Gal/GalNAc lectin IgA, the impact of parasite burden on symptoms, and potential role of Prevotella copri in E. histolytica diarrhea are described.
93 citations
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TL;DR: The study found the same three risk factors for the two biotypes of cholera including proximity to surface water, high population density, and poor educational level.
93 citations
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TL;DR: Zinc-deficient Bangladeshi infants showed improvements in growth rate and a reduced incidence of acute lower respiratory infection after zinc supplementation, and supplementation improved only biochemical zinc status.
93 citations
Authors
Showing all 3121 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stanley Falkow | 134 | 349 | 62461 |
Myron M. Levine | 123 | 789 | 60865 |
Roger I. Glass | 116 | 474 | 49151 |
Robert F. Breiman | 105 | 473 | 43927 |
Harry B. Greenberg | 100 | 433 | 34941 |
Barbara J. Stoll | 100 | 390 | 42107 |
Andrew M. Prentice | 99 | 550 | 46628 |
Robert H. Gilman | 96 | 903 | 43750 |
Robert E. Black | 92 | 201 | 56887 |
Johan Ärnlöv | 91 | 386 | 90490 |
Juan Jesus Carrero | 89 | 522 | 66970 |
John D. Clemens | 89 | 506 | 28981 |
William A. Petri | 85 | 507 | 26906 |
Toshifumi Hibi | 82 | 808 | 28674 |
David A. Sack | 80 | 437 | 23320 |