Institution
International Centre for Diarrhoeal Disease Research, Bangladesh
Facility•Dhaka, Bangladesh•
About: International Centre for Diarrhoeal Disease Research, Bangladesh is a facility organization based out in Dhaka, Bangladesh. It is known for research contribution in the topics: Population & Vibrio cholerae. The organization has 3103 authors who have published 5238 publications receiving 226880 citations. The organization is also known as: SEATO Cholera Research Laboratory & Bangladesh International Centre for Diarrhoeal Disease Research.
Topics: Population, Vibrio cholerae, Cholera, Diarrhea, Health care
Papers published on a yearly basis
Papers
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TL;DR: Home fortification with small-quantity LNSs, but not MNP, during the first 1000 d improved child linear growth and head size in rural Bangladesh.
77 citations
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TL;DR: PCR-based serotyping of Streptococcus pneumoniae strains in Asia could improve ascertainment of pneumococcal serotype distributions, especially for meningitis in settings with high prior use of antibiotics.
Abstract: BACKGROUND: PCR-based serotyping of Streptococcus pneumoniae has been proposed as a simpler approach than conventional methods, but has not been applied to strains in Asia where serotypes are diverse and different from other part of the world. Furthermore, PCR has not been used to determine serotype distribution in culture-negative meningitis cases. METHODOLOGY: Thirty six serotype-specific primers, 7 newly designed and 29 previously published, were arranged in 7 multiplex PCR sets, each in new hierarchies designed for overall serotype distribution in Bangladesh, and specifically for meningitis and non-meningitis isolates. Culture-negative CSF specimens were then tested directly for serotype-specific sequences using the meningitis-specific set of primers. PCR-based serotyping of 367 strains of 56 known serotypes showed 100% concordance with quellung reaction test. The first 7 multiplex reactions revealed the serotype of 40% of all, and 31% and 48% non-meningitis and meningitis isolates, respectively. By redesigning the multiplex scheme specifically for non-meningitis or meningitis, the quellung reaction of 43% and 48% of respective isolates could be identified. Direct examination of 127 culture-negative CSF specimens, using the meningitis-specific set of primers, yielded serotype for 51 additional cases. CONCLUSIONS: This PCR approach, could improve ascertainment of pneumococcal serotype distributions, especially for meningitis in settings with high prior use of antibiotics.
77 citations
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TL;DR: Adjunct therapy with butyrate during shigellosis led to early reduction of inflammation and enhanced LL-37 expression in the rectal epithelia with prolonged release of LL-36 in the stool and improvement in rectal histopathology.
Abstract: Treatment of shigellosis in rabbits with butyrate reduces clinical severity and counteracts the downregulation of cathelicidin (CAP-18) in the large intestinal epithelia Here, we aimed to evaluate whether butyrate can be used as an adjunct to antibiotics in the treatment of shigellosis in patients A randomized, double-blind, placebo-controlled, parallel-group designed clinical trial was conducted Eighty adult patients with shigellosis were randomized to either the Intervention group (butyrate, n = 40) or the Placebo group (normal saline, n = 40) The Intervention group was given an enema containing sodium butyrate (80 mM), twice daily for 3 days, while the Placebo group received the same dose of normal saline The primary endpoint of the trial was to assess the efficacy of butyrate in improving clinical, endoscopic and histological features of shigellosis The secondary endpoint was to study the effect of butyrate on the induction of antimicrobial peptides in the rectum Clinical outcomes were assessed and concentrations of antimicrobial peptides (LL-37, human beta defensin1 [HBD-1] and human beta defensin 3 [HBD-3]) and pro-inflammatory cytokines (interleukin-1β [IL-1β] and interleukin-8 [IL-8]) were measured in the stool Sigmoidoscopic and histopathological analyses, and immunostaining of LL-37 in the rectal mucosa were performed in a subgroup of patients Compared with placebo, butyrate therapy led to the early reduction of macrophages, pus cells, IL-8 and IL-1β in the stool and improvement in rectal histopathology Butyrate treatment induced LL-37 expression in the rectal epithelia Stool concentration of LL-37 remained significantly higher in the Intervention group on days 4 and 7 Adjunct therapy with butyrate during shigellosis led to early reduction of inflammation and enhanced LL-37 expression in the rectal epithelia with prolonged release of LL-37 in the stool ClinicalTrialsgov, NCT00800930
77 citations
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TL;DR: The value of gaining in-depth understanding of household food insecurity is affirms, and in many situations, this approach, rather than translating questions developed elsewhere, may best lead to suitable experience-based measures of food insecurity.
Abstract: This research aimed to gain in-depth understanding of the experience of household food insecurity in rural Bangladesh and to develop a direct measure of it from this understanding. Using naturalistic, emergent inquiry, in-depth interviews were conducted with 21 rural women living in diverse situations using a semistructured interview guide. Two analytic strategies classified households on food insecurity and elicited themes that were the basis for classification. Survey questions were developed to capture themes, and were revised after review, field testing, and ranking and pile-sorting exercises. Four gradations of severity of food insecurity resulted, based on nine themes: meals, cooking, rice, fish, perishable foods, snacks, festival food, other expenditures and management strategies. The emergent conceptualization of food insecurity differs from that found from naturalistic research in other countries. The developed food insecurity measure has 11 questions. This research affirms the value of gaining in-depth understanding of household food insecurity. In many situations, this approach, rather than translating questions developed elsewhere, may best lead to suitable experience-based measures of food insecurity.
77 citations
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World Health Organization1, University of Bergen2, Save the Children3, University of London4, University of São Paulo5, University of Edinburgh6, Bandim Health Project7, University of Khartoum8, Kathmandu Medical College9, University of Alabama at Birmingham10, International Centre for Diarrhoeal Disease Research, Bangladesh11, Johns Hopkins University12, Universidade Federal de Pelotas13, University of Southern Denmark14, Yale University15, Translational Health Science and Technology Institute16, University of Aberdeen17, Aga Khan University18, University of North Carolina at Chapel Hill19, Charité20, State University of Campinas21, University of Alberta22, University College London23, National Institutes of Health24, RTI International25, All India Institute of Medical Sciences26, Yıldırım Beyazıt University27, University of Oxford28, Wellcome Trust29, Bill & Melinda Gates Foundation30, Moi University31, University of Southampton32, University of California, San Francisco33, Pakistan Institute of Medical Sciences34, University of Technology, Sydney35, Japan International Cooperation Agency36, Saint Louis University37, Shaheed Suhrawardy Medical College38, Karolinska Institutet39, McGill University40, University of Manchester41, Dalhousie University42, University of Toronto43, University of Amsterdam44, University of Malawi45, Boston Children's Hospital46, United States Agency for International Development47, University of Tübingen48, University of Tennessee Health Science Center49, University of Calgary50, University of Georgia51, Ministry of Health and Family Welfare52, University of Kinshasa53, Utrecht University54, Rice University55, Edith Cowan University56, New York State Office for People With Developmental Disabilities57, Médecins Sans Frontières58
TL;DR: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list.
Abstract: BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025. METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts. RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour. CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.
77 citations
Authors
Showing all 3121 results
Name | H-index | Papers | Citations |
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Stanley Falkow | 134 | 349 | 62461 |
Myron M. Levine | 123 | 789 | 60865 |
Roger I. Glass | 116 | 474 | 49151 |
Robert F. Breiman | 105 | 473 | 43927 |
Harry B. Greenberg | 100 | 433 | 34941 |
Barbara J. Stoll | 100 | 390 | 42107 |
Andrew M. Prentice | 99 | 550 | 46628 |
Robert H. Gilman | 96 | 903 | 43750 |
Robert E. Black | 92 | 201 | 56887 |
Johan Ärnlöv | 91 | 386 | 90490 |
Juan Jesus Carrero | 89 | 522 | 66970 |
John D. Clemens | 89 | 506 | 28981 |
William A. Petri | 85 | 507 | 26906 |
Toshifumi Hibi | 82 | 808 | 28674 |
David A. Sack | 80 | 437 | 23320 |