Institution
International Centre for Diarrhoeal Disease Research, Bangladesh
Facility•Dhaka, Bangladesh•
About: International Centre for Diarrhoeal Disease Research, Bangladesh is a facility organization based out in Dhaka, Bangladesh. It is known for research contribution in the topics: Population & Vibrio cholerae. The organization has 3103 authors who have published 5238 publications receiving 226880 citations. The organization is also known as: SEATO Cholera Research Laboratory & Bangladesh International Centre for Diarrhoeal Disease Research.
Topics: Population, Vibrio cholerae, Cholera, Public health, Health care
Papers published on a yearly basis
Papers
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University of Maryland, Baltimore1, Aga Khan University2, International Centre for Diarrhoeal Disease Research, Bangladesh3, Medical Research Council4, University of Barcelona5, Centers for Disease Control and Prevention6, Norwegian Institute of Public Health7, Tel Aviv University8, University of Melbourne9, University of Virginia10
TL;DR: The enormous African/Asian Cryptosporidium disease burden warrants investments to develop vaccines, diagnostics and therapies.
Abstract: Background
The importance of Cryptosporidium as a pediatric enteropathogen in developing countries is recognized.
Methods
Data from the Global Enteric Multicenter Study (GEMS), a 3-year, 7-site, case-control study of moderate-to-severe diarrhea (MSD) and GEMS-1A (1-year study of MSD and less-severe diarrhea [LSD]) were analyzed. Stools from 12,110 MSD and 3,174 LSD cases among children aged <60 months and from 21,527 randomly-selected controls matched by age, sex and community were immunoassay-tested for Cryptosporidium. Species of a subset of Cryptosporidium-positive specimens were identified by PCR; GP60 sequencing identified anthroponotic C. parvum. Combined annual Cryptosporidium-attributable diarrhea incidences among children aged <24 months for African and Asian GEMS sites were extrapolated to sub-Saharan Africa and South Asian regions to estimate region-wide MSD and LSD burdens. Attributable and excess mortality due to Cryptosporidium diarrhea were estimated.
Findings
Cryptosporidium was significantly associated with MSD and LSD below age 24 months. Among Cryptosporidium-positive MSD cases, C. hominis was detected in 77.8% (95% CI, 73.0%-81.9%) and C. parvum in 9.9% (95% CI, 7.1%-13.6%); 92% of C. parvum tested were anthroponotic genotypes. Annual Cryptosporidium-attributable MSD incidence was 3.48 (95% CI, 2.27–4.67) and 3.18 (95% CI, 1.85–4.52) per 100 child-years in African and Asian infants, respectively, and 1.41 (95% CI, 0.73–2.08) and 1.36 (95% CI, 0.66–2.05) per 100 child-years in toddlers. Corresponding Cryptosporidium-attributable LSD incidences per 100 child-years were 2.52 (95% CI, 0.33–5.01) and 4.88 (95% CI, 0.82–8.92) in infants and 4.04 (95% CI, 0.56–7.51) and 4.71 (95% CI, 0.24–9.18) in toddlers. We estimate 2.9 and 4.7 million Cryptosporidium-attributable cases annually in children aged <24 months in the sub-Saharan Africa and India/Pakistan/Bangladesh/Nepal/Afghanistan regions, respectively, and ~202,000 Cryptosporidium-attributable deaths (regions combined). ~59,000 excess deaths occurred among Cryptosporidium-attributable diarrhea cases over expected if cases had been Cryptosporidium-negative.
Conclusions
The enormous African/Asian Cryptosporidium disease burden warrants investments to develop vaccines, diagnostics and therapies.
173 citations
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TL;DR: Assessment of prevalence of arsenic exposure through drinking water and skin lesions in Bangladesh showed sex, age, and socioeconomic differentials in both exposure andSkin lesions clearly showed the urgency of effective arsenic mitigation activities.
Abstract: Study objective: To assess prevalence of arsenic exposure through drinking water and skin lesions, and their variation by geographical area, age, sex, and socioeconomic conditions. Design, setting, and participants: Skin lesion cases were identified by screening the entire population above 4 years of age (n = 166 934) living in Matlab, a rural area in Bangladesh, during January 2002 and August 2003. The process of case identification involved initial skin examinations in the field, followed by verification by physicians in a clinic, and final confirmation by two independent experts reviewing photographs. The tubewell water arsenic concentrations (n = 13 286) were analysed by atomic absorption spectrometry. Drinking water history since 1970 was obtained for each person. Exposure information was constructed using drinking water histories and data on water arsenic concentrations. Main results: The arsenic concentrations ranged from Conclusions: The result showed sex, age, and socioeconomic differentials in both exposure and skin lesions. Findings clearly showed the urgency of effective arsenic mitigation activities.
172 citations
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TL;DR: The efficacy of the macrolide agent azithromycin for treating shigellosis was evaluated and the oral form of the extended-spectrum cephalosporin cefixime, although active in vitro against multidrug-resistant Shigella strains, was ineffective in achieving clinical and bacteriologic cure.
Abstract: Background: Treatment of shigellosis is currently limited by the high prevalence of multidrug-resistant strains of Shigella. Objective: To determine the efficacy of azithromycin in the treatment of...
172 citations
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Aga Khan University1, University of Virginia2, Federal University of Ceará3, National Institutes of Health4, Johns Hopkins University5, Pennsylvania State University6, University of Venda7, International Centre for Diarrhoeal Disease Research, Bangladesh8, Christian Medical College & Hospital9, Haydom Lutheran Hospital10, Tribhuvan University11, Kathmandu12, Haukeland University Hospital13, Duke University14, University of Illinois at Chicago15, Temple University16, University of Bergen17
TL;DR: The MAL-ED study represents a novel analytical framework and explicitly evaluates multiple putative EE pathways in combination and using an unprecedented quantity of data to demonstrate that enteric infection alters both fecal markers of inflammation and permeability.
171 citations
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TL;DR: Physical abuse by a partner during pregnancy is an independent risk factor for LBW, and low birth weight was associated with physical partner abuse even after adjustment for age, parity, smoking, and socioeconomic status.
171 citations
Authors
Showing all 3121 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stanley Falkow | 134 | 349 | 62461 |
Myron M. Levine | 123 | 789 | 60865 |
Roger I. Glass | 116 | 474 | 49151 |
Robert F. Breiman | 105 | 473 | 43927 |
Harry B. Greenberg | 100 | 433 | 34941 |
Barbara J. Stoll | 100 | 390 | 42107 |
Andrew M. Prentice | 99 | 550 | 46628 |
Robert H. Gilman | 96 | 903 | 43750 |
Robert E. Black | 92 | 201 | 56887 |
Johan Ärnlöv | 91 | 386 | 90490 |
Juan Jesus Carrero | 89 | 522 | 66970 |
John D. Clemens | 89 | 506 | 28981 |
William A. Petri | 85 | 507 | 26906 |
Toshifumi Hibi | 82 | 808 | 28674 |
David A. Sack | 80 | 437 | 23320 |