International Institute of Information Technology, Hyderabad

About: International Institute of Information Technology, Hyderabad is a education organization based out in Hyderabad, India. It is known for research contribution in the topics: Computer science & Authentication. The organization has 2048 authors who have published 3677 publications receiving 45319 citations. The organization is also known as: IIIT Hyderabad & International Institute of Information Technology (IIIT).

Understanding the thermostability and activity of Bacillus subtilis lipase mutants: insights from molecular dynamics simulations.

Abstract: Improving the thermostability of industrial enzymes is an important protein engineering challenge. Point mutations, induced to increase thermostability, affect the structure and dynamics of the target protein in several ways and thus can also affect its activity. There appears to be no general rules for improving the thermostabilty of enzymes without adversely affecting their enzymatic activity. We report MD simulations, of wild type Bacillus subtilis lipase (WT) and its six progressively thermostable mutants (2M, 3M, 4M, 6M, 9M, and 12M), performed at different temperatures, to address this issue. Less thermostable mutants (LTMs), 2M to 6M, show WT-like dynamics at all simulation temperatures. However, the two more thermostable mutants (MTMs) show the required flexibility at appropriate temperature ranges and maintain conformational stability at high temperature. They show a deep and rugged free-energy landscape, confining them within a near-native conformational space by conserving noncovalent interactions, and thus protecting them from possible aggregation. In contrast, the LTMs having marginally higher thermostabilities than WT show greater probabilities of accessing non-native conformations, which, due to aggregation, have reduced possibilities of reverting to their respective native states under refolding conditions. Our analysis indicates the possibility of nonadditive effects of point mutations on the conformational stability of LTMs.

Designing Secure User Authentication Protocol for Big Data Collection in IoT-Based Intelligent Transportation System

Abstract: Secure access of the real-time data from the Internet-of-Things (IoT) smart devices (e.g., vehicles) by a legitimate external party (user) is an important security service for big data collection in the IoT-based intelligent transportation system (ITS). To deal with this important issue, we design a new three-factor user authentication scheme, called UAP-BCIoT, which relies on elliptic-curve cryptography (ECC). The mutual authentication between the user and an IoT device happens via the semitrusted cloud-gateway (CG) node in UAP-BCIoT. UAP-BCIoT supports several functionality features needed for IoT-based ITS environment including IoT smart device credential validation and big data analytics. A detailed security analysis is conducted based on the defined threat model to show that UAP-BCIoT is resilient against many known attacks. A thorough comparative study reveals that UAP-BCIoT supports better security, offers various functionality attributes, and also provides similar costs in communication as well computation as compared to other relevant schemes Finally, the practical demonstration of the proposed UAP-BCIoT is also provided to measure its impact on the network performance parameters.

Retrieval from document image collections

Abstract: This paper presents a system for retrieval of relevant documents from large document image collections. We achieve effective search and retrieval from a large collection of printed document images by matching image features at word-level. For representations of the words, profile-based and shape-based features are employed. A novel DTW-based partial matching scheme is employed to take care of morphologically variant words. This is useful for grouping together similar words during the indexing process.The system supports cross-lingual search using OM-Trans transliteration and a dictionary-based approach. System-level issues for retrieval (eg. scalability, effective delivery etc.) are addressed in this paper.

Novel Reversible `TSG' Gate and Its Application for Designing Components of Primitive Reversible/Quantum ALU

Abstract: In recent years, reversible logic has emerged as a promising computing paradigm having application in low power CMOS, quantum computing, nanotechnology, and optical computing The classical set of gates such as AND, OR, and EXOR are not reversible This paper utilizes a new 4*4 reversible gate called TSG gate to build the components of a primitive reversible/quantum ALU The most significant aspect of the TSG gate is that it can work singly as a reversible full adder, that is reversible full adder can now be implemented with a single gate only A Novel reversible 4:2 compressor is also designed from the TSG gate which is later used to design a novel 8times8 reversible Wallace tree multiplier It is proved that the adder, 4:2 compressor and multiplier architectures designed using the TSG gate are better than their counterparts available in literature, in terms of number of reversible gates and garbage outputs This is perhaps, the first attempt to design a reversible 4:2 compressor and a reversible Wallace tree multiplier as far as existing literature and our knowledge is concerned Thus, this paper provides an initial threshold to build more complex systems which can execute complicated operations using reversible logic