Institution
International School for Advanced Studies
Education•Trieste, Friuli-Venezia Giulia, Italy•
About: International School for Advanced Studies is a education organization based out in Trieste, Friuli-Venezia Giulia, Italy. It is known for research contribution in the topics: Galaxy & Dark matter. The organization has 3751 authors who have published 13433 publications receiving 588454 citations. The organization is also known as: SISSA & Scuola Internazionale Superiore di Studi Avanzati.
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TL;DR: This work identifies a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 (Uchl1), a gene involved in brain function and neurodegenerative diseases, and identifies a new functional class of lncRNAs.
Abstract: Most of the mammalian genome is transcribed. This generates a vast repertoire of transcripts that includes protein-coding messenger RNAs, long non-coding RNAs (lncRNAs) and repetitive sequences, such as SINEs (short interspersed nuclear elements). A large percentage of ncRNAs are nuclear-enriched with unknown function. Antisense lncRNAs may form sense-antisense pairs by pairing with a protein-coding gene on the opposite strand to regulate epigenetic silencing, transcription and mRNA stability. Here we identify a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 (Uchl1), a gene involved in brain function and neurodegenerative diseases. Antisense Uchl1 increases UCHL1 protein synthesis at a post-transcriptional level, hereby identifying a new functional class of lncRNAs. Antisense Uchl1 activity depends on the presence of a 5' overlapping sequence and an embedded inverted SINEB2 element. These features are shared by other natural antisense transcripts and can confer regulatory activity to an artificial antisense to green fluorescent protein. Antisense Uchl1 function is under the control of stress signalling pathways, as mTORC1 inhibition by rapamycin causes an increase in UCHL1 protein that is associated to the shuttling of antisense Uchl1 RNA from the nucleus to the cytoplasm. Antisense Uchl1 RNA is then required for the association of the overlapping sense protein-coding mRNA to active polysomes for translation. These data reveal another layer of gene expression control at the post-transcriptional level.
844 citations
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TL;DR: In this paper, the authors acknowledge the support from the ERC Consolidator Grant (CRA 1.05.01.94) and Partial Support Agreement (PSA) for the STARKEY project.
Abstract: We acknowledge the support from the ERC Consolidator
Grant funding scheme (project STARKEY, G.A. n. 615604).
L.G. and T.S.R. acknowledge partial support from PRIN INAF
2014—CRA 1.05.01.94.05.
843 citations
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INAF1, Pennsylvania State University2, University of Milan3, Goddard Space Flight Center4, National Research Council5, Kavli Institute for Theoretical Physics6, International School for Advanced Studies7, Weizmann Institute of Science8, University of Nevada, Las Vegas9, Nanjing University10, Polaris Industries11, University of Leicester12, Sonoma State University13, Universities Space Research Association14, Los Alamos National Laboratory15
TL;DR: A supernova is caught in the act of exploding, directly observing the shock break-out, which indicates that the GRB progenitor was a Wolf–Rayet star.
Abstract: A link between long γ-ray bursts (GRBs) and supernovae has been established, but whether there is a similar relationship between the weaker and softer X-ray flashes and supernovae is unclear. GRB/XRF 060218, spotted by the Swift satellite on 18 February this year, may supply that missing link. In the first of four papers on this novel burster, Campana et al. report the sighting of the X-ray signature of a shock break-out, possible evidence of a supernova in progress. Pian et al. report the optical discovery of a type Ic supernova 2006aj associated with GRB/XRF 060218. Soderberg et al. report radio and X-ray observations that show that XRF 060218 is 100 times less energetic than, but of a type that is ten times more common than cosmological GRBs. Mazzali et al. modelled the spectra and light curve of SN 2006aj to show that it had a much smaller explosion energy and ejected much less mass than other GRB-supernovae, suggesting that it was produced by a star with a mass was only about 20 times that of the Sun, leaving behind a neutron star, rather than a black hole. Observations of the close gamma-ray burst GRB 060218 and its connection to supernova SN 2006aj reveal the break-out of a shock wave driven by a mildly relativistic shell into the dense wind surrounding the GRB progenitor. These observation catch a supernova in the act of exploding. Although the link between long γ-ray bursts (GRBs) and supernovae has been established1,2,3,4, hitherto there have been no observations of the beginning of a supernova explosion and its intimate link to a GRB. In particular, we do not know how the jet that defines a γ-ray burst emerges from the star's surface, nor how a GRB progenitor explodes. Here we report observations of the relatively nearby GRB 060218 (ref. 5) and its connection to supernova SN 2006aj (ref. 6). In addition to the classical non-thermal emission, GRB 060218 shows a thermal component in its X-ray spectrum, which cools and shifts into the optical/ultraviolet band as time passes. We interpret these features as arising from the break-out of a shock wave driven by a mildly relativistic shell into the dense wind surrounding the progenitor7. We have caught a supernova in the act of exploding, directly observing the shock break-out, which indicates that the GRB progenitor was a Wolf–Rayet star.
835 citations
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01 Sep 2015TL;DR: In this article, the authors provide a thorough introduction to the mathematical and algorithmic aspects of certified reduced basis methods for parametrized partial differential equations, including model construction, error estimation and computational efficiency.
Abstract: This book provides a thorough introduction to the mathematical and algorithmic aspects of certified reduced basis methods for parametrized partial differential equations. Central aspects ranging from model construction, error estimation and computational efficiency to empirical interpolation methods are discussed in detail for coercive problems. More advanced aspects associated with time-dependent problems, non-compliant and non-coercive problems and applications with geometric variation are also discussed as examples.
831 citations
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TL;DR: In this paper, the implications of Planck data for models of dark energy (DE) and modified gravity (MG) beyond the standard cosmological constant scenario were studied, and it was shown that the density of DE at early times has to be below 2% of the critical density, even when forced to play a role for z < 50.
Abstract: We study the implications of Planck data for models of dark energy (DE) and modified gravity (MG) beyond the standard cosmological constant scenario. We start with cases where the DE only directly affects the background evolution, considering Taylor expansions of the equation of state w(a), as well as principal component analysis and parameterizations related to the potential of a minimally coupled DE scalar field. When estimating the density of DE at early times, we significantly improve present constraints and find that it has to be below ~2% (at 95% confidence) of the critical density, even when forced to play a role for z < 50 only. We then move to general parameterizations of the DE or MG perturbations that encompass both effective field theories and the phenomenology of gravitational potentials in MG models. Lastly, we test a range of specific models, such as k-essence, f(R) theories, and coupled DE. In addition to the latest Planck data, for our main analyses, we use background constraints from baryonic acoustic oscillations, type-Ia supernovae, and local measurements of the Hubble constant. We further show the impact of measurements of the cosmological perturbations, such as redshift-space distortions and weak gravitational lensing. These additional probes are important tools for testing MG models and for breaking degeneracies that are still present in the combination of Planck and background data sets. All results that include only background parameterizations (expansion of the equation of state, early DE, general potentials in minimally-coupled scalar fields or principal component analysis) are in agreement with ΛCDM. When testing models that also change perturbations (even when the background is fixed to ΛCDM), some tensions appear in a few scenarios: the maximum one found is ~2σ for Planck TT+lowP when parameterizing observables related to the gravitational potentials with a chosen time dependence; the tension increases to, at most, 3σ when external data sets are included. It however disappears when including CMB lensing.
816 citations
Authors
Showing all 3802 results
Name | H-index | Papers | Citations |
---|---|---|---|
Sabino Matarrese | 155 | 775 | 123278 |
G. de Zotti | 154 | 718 | 121249 |
J. González-Nuevo | 144 | 500 | 108318 |
Matt J. Jarvis | 144 | 1064 | 85559 |
Carlo Baccigalupi | 137 | 518 | 104722 |
L. Toffolatti | 136 | 376 | 95529 |
Michele Parrinello | 133 | 637 | 94674 |
Marzio Nessi | 129 | 1046 | 78641 |
Luigi Danese | 128 | 394 | 92073 |
Lidia Smirnova | 127 | 944 | 75865 |
Michele Pinamonti | 126 | 846 | 69328 |
David M. Alexander | 125 | 652 | 60686 |
Davide Maino | 124 | 410 | 88117 |
Dipak Munshi | 124 | 365 | 84322 |
Peter Onyisi | 114 | 694 | 60392 |