International School for Advanced Studies

About: International School for Advanced Studies is a education organization based out in Trieste, Friuli-Venezia Giulia, Italy. It is known for research contribution in the topics: Galaxy & Dark matter. The organization has 3751 authors who have published 13433 publications receiving 588454 citations. The organization is also known as: SISSA & Scuola Internazionale Superiore di Studi Avanzati.

The master space of n=1 gauge theories

Abstract: The full moduli space of a class of = 1 supersymmetric gauge theories is studied. For gauge theories living on a stack of D3-branes at Calabi-Yau singularities , is a combination of the mesonic and baryonic branches. In consonance with the mathematical literature, the single brane moduli space is called the master space . Illustrating with a host of explicit examples, we exhibit many algebro-geometric properties of the master space such as when is toric Calabi-Yau, behaviour of its Hilbert series, its irreducible components and its symmetries. In conjunction with the plethystic programme, we investigate the counting of BPS gauge invariants, baryonic and mesonic, using the geometry of and show how its refined Hilbert series not only engenders the generating functions for the counting but also beautifully encode ``hidden'' global symmetries of the gauge theory which manifest themselves as symmetries of the complete moduli space for N number of branes.

Optimal Strokes for Low Reynolds Number Swimmers: An Example

Abstract: Swimming, i.e., being able to advance in the absence of external forces by performing cyclic shape changes, is particularly demanding at low Reynolds numbers. This is the regime of interest for micro-organisms and micro- or nano-robots. We focus in this paper on a simple yet representative example: the three-sphere swimmer of Najafi and Golestanian (Phys. Rev. E, 69, 062901–062904, 2004). For this system, we show how to cast the problem of swimming in the language of control theory, prove global controllability (which implies that the three-sphere swimmer can indeed swim), and propose a numerical algorithm to compute optimal strokes (which turn out to be suitably defined sub-Riemannian geodesics).

Extremely hard GRB spectra prune down the forest of emission models

Abstract: We consider the evidence for very hard low energy spectra during the prompt phase of Gamma-Ray Bursts (GRB). In particular we examine the spectral evolution of GRB 980306 together with the detailed analysis of some other bursts already presented in the literature (GRB 911118, GRB 910807, GRB 910927 and GRB 970111), and check for the significance of their hardness (i.e. extremely steep spectral slopes below the EFE peak) by applying dierent tests. These bursts, detected by the Burst And Transient Source Experiment (BATSE) in the30 keV-2 MeV energy range, are suciently bright to allow time resolved spectral studies on time intervals of the order of tenths of a second. We discuss the hard spectra of these bursts and their evolution in the context of several non-thermal emission models, which all appear inadequate to account for these cases. The extremely hard spectra, which are detected in the early part of the BATSE light curve, are also compared with a black body spectral model: the resulting fits are remarkably good, except for an excess at high energies (in several cases) which could be simply accounted for by the presence of a supra-thermal component. The findings on the possible thermal character of the evolving spectrum and the implications on the GRB physical scenario are considered in the frameworks of photospheric models for a fireball which is becoming optically thin, and of Compton drag models, in which the fireball boosts "ambient" seed photons by its own bulk motion. Both models, according to simple estimates, appear to be qualitatively and quantitatively consistent with the found spectral characteristics, although their possible caveats are discussed.

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

Abstract: Recent evidence indicates synaptic dysfunction as an early mechanism affected in neuroinflammatory diseases, such as multiple sclerosis, which are characterized by chronic microglia activation. However, the mode(s) of action of reactive microglia in causing synaptic defects are not fully understood. In this study, we show that inflammatory microglia produce extracellular vesicles (EVs) which are enriched in a set of miRNAs that regulate the expression of key synaptic proteins. Among them, miR-146a-5p, a microglia-specific miRNA not present in hippocampal neurons, controls the expression of presynaptic synaptotagmin1 (Syt1) and postsynaptic neuroligin1 (Nlg1), an adhesion protein which play a crucial role in dendritic spine formation and synaptic stability. Using a Renilla-based sensor, we provide formal proof that inflammatory EVs transfer their miR-146a-5p cargo to neuron. By western blot and immunofluorescence analysis we show that vesicular miR-146a-5p suppresses Syt1 and Nlg1 expression in receiving neurons. Microglia-to-neuron miR-146a-5p transfer and Syt1 and Nlg1 downregulation do not occur when EV-neuron contact is inhibited by cloaking vesicular phosphatidylserine residues and when neurons are exposed to EVs either depleted of miR-146a-5p, produced by pro-regenerative microglia, or storing inactive miR-146a-5p, produced by cells transfected with an anti-miR-146a-5p. Morphological analysis reveals that prolonged exposure to inflammatory EVs leads to significant decrease in dendritic spine density in hippocampal neurons in vivo and in primary culture, which is rescued in vitro by transfection of a miR-insensitive Nlg1 form. Dendritic spine loss is accompanied by a decrease in the density and strength of excitatory synapses, as indicated by reduced mEPSC frequency and amplitude. These findings link inflammatory microglia and enhanced EV production to loss of excitatory synapses, uncovering a previously unrecognized role for microglia-enriched miRNAs, released in association to EVs, in silencing of key synaptic genes.

Holographic entanglement plateaux

Abstract: We consider the entanglement entropy for holographic field theories in finite volume. We show that the Araki-Lieb inequality is saturated for large enough subregions, implying that the thermal entropy can be recovered from the knowledge of the region and its complement. We observe that this actually is forced upon us in holographic settings due to non-trivial features of the causal wedges associated with a given boundary region. In the process, we present an infinite set of extremal surfaces in Schwarzschild-AdS geometry anchored on a given entangling surface. We also offer some speculations regarding the homology constraint required for computing holographic entanglement entropy.