International School for Advanced Studies

About: International School for Advanced Studies is a education organization based out in Trieste, Friuli-Venezia Giulia, Italy. It is known for research contribution in the topics: Galaxy & Dark matter. The organization has 3751 authors who have published 13433 publications receiving 588454 citations. The organization is also known as: SISSA & Scuola Internazionale Superiore di Studi Avanzati.

Accurate and efficient description of protein vibrational dynamics: comparing molecular dynamics and Gaussian models.

Abstract: Current all-atom potential based molecular dynamics (MD) allows the identification of a protein's functional motions on a wide-range of timescales, up to few tens of nanoseconds. However, functional, large-scale motions of proteins may occur on a timescale currently not accessible by all-atom potential based MD. To avoid the massive computational effort required by this approach, several simplified schemes have been introduced. One of the most satisfactory is the Gaussian network approach based on the energy expansion in terms of the deviation of the protein backbone from its native configuration. Here, we consider an extension of this model that captures in a more realistic way the distribution of native interactions due to the introduction of effective side-chain centroids. Since their location is entirely determined by the protein backbone, the model is amenable to the same exact and computationally efficient treatment as previous simpler models. The ability of the model to describe the correlated motion of protein residues in thermodynamic equilibrium is established through a series of successful comparisons with an extensive (14 ns) MD simulation based on the AMBER potential of HIV-1 protease in complex with a peptide substrate. Thus, the model presented here emerges as a powerful tool to provide preliminary, fast yet accurate characterizations of protein near-native motion.

Gluino Contribution to Radiative B Decays: Organization of QCD Corrections and Leading Order Results

Abstract: The gluino-induced contributions to the decay b → s are investigated in supersymmetric frameworks with generic sources of flavour violation. It is shown that, when QCD corrections are taken into account, the relevant operator basis of the Standard Model effective Hamiltonian gets enlarged to

A new generation of PARSEC-COLIBRI stellar isochrones including the TP-AGB phase

Abstract: We introduce a new generation of PARSEC-COLIBRI stellar isochrones that include a detailed treatment of the thermally-pulsing asymptotic giant branch (TP-AGB) phase, and covering a wide range of initial metallicities (0.0001

Origin of spontaneous symmetry breaking in theories with large extra dimensions

Abstract: We suggest that the electroweak Higgs particles can be identified with extra-dimensional components of the gauge fields, which after compactification on a certain topologically non-trivial background become tachyonic and condense. If the tachyonic mass is a tree level effect, the natural scale of the gauge symmetry breaking is set by the inverse radius of the internal space, which, in case of the electroweak symmetry, must be around $\sim 1/$TeV. We discuss the possibility of a vanishing tree level mass for the Higgs. In such a scenario the tachyonic mass can be induced by quantum loops and can be naturally smaller than the compactification scale. We give an example in which this possibility can be realized. Starting from an Einstein--Yang--Mills theory coupled to fermions in 10-dimensions, we are able to reproduce the spectrum of the Standard Model like chiral fermions and Higgs type scalars in 4-dimensions upon compactifying on ${\mathbb{C}}P^1\times {\mathbb{C}}P^2$. The existence of a monopole solution on ${\mathbb{C}}P^1$ and a self dual U(1) instanton on ${\mathbb{C}}P^2$ are essential in obtaining chiral fermions as well as tachyonic or massless scalars in 4-dimensions. We give a simple rule which helps us to identify the presence of tachyons on the monopole background on $S^2$.