International School for Advanced Studies

About: International School for Advanced Studies is a education organization based out in Trieste, Friuli-Venezia Giulia, Italy. It is known for research contribution in the topics: Galaxy & Dark matter. The organization has 3751 authors who have published 13433 publications receiving 588454 citations. The organization is also known as: SISSA & Scuola Internazionale Superiore di Studi Avanzati.

Somatosensory cortical neuronal population activity across states of anaesthesia

Abstract: Experiments were carried out to learn about changes in sensory cortical processing associated with different levels of anaesthesia. Traditionally this question has been addressed by studying single neurons. Because state changes are likely to influence the relationships between neurons, the present experiments were undertaken to investigate the spatial and temporal firing patterns distributed across cortex. Using 5 x 5 or 10 x 10 microelectrode arrays, spontaneous and stimulus-evoked activity of multineuron clusters was recorded from rat somatosensory 'barrel' cortex (the whisker representation) during a light surgical stage of urethane anaesthesia, and after two supplemental doses of urethane which led to intermediate and deep levels of anaesthesia. At all depths of anaesthesia, spontaneously occurring action potentials at a single electrode tended to be clustered into 'bursts.' With increasing anaesthetic depth, bursts became more prominent and rhythmic, and increasingly synchronized between cortical barrel-columns. Burst frequency decreased and fewer spikes occurred outside bursts, leading to a decrease in the overall spontaneous firing rate. The cortical territory engaged by individual whiskers contracted with increasing depth of anaesthesia, leading to the spatial segregation of whisker representations. At all stages of anaesthesia, whisker stimulation produced the maximal cortical response when delivered close to burst onset. These observations show that ongoing spontaneous activity modulates sensory response properties and makes peripheral tactile information accessible to a cortical territory whose size is determined by the phase of burst cycle. The possible significance of the cyclic cortical responsiveness encountered during urethane anaesthesia to cortical processing in awake rats is considered.

Exploring cosmic origins with CORE: Inflation

Abstract: We forecast the scientific capabilities to improve our understanding of cosmic inflation of CORE, a proposed CMB space satellite submitted in response to the ESA fifth call for a medium-size mission opportunity. The CORE satellite will map the CMB anisotropies in temperature and polarization in 19 frequency channels spanning the range 60–600 GHz. CORE will have an aggregate noise sensitivity of 1.7 μK⋅ arcmin and an angular resolution of 5' at 200 GHz. We explore the impact of telescope size and noise sensitivity on the inflation science return by making forecasts for several instrumental configurations. This study assumes that the lower and higher frequency channels suffice to remove foreground contaminations and complements other related studies of component separation and systematic effects, which will be reported in other papers of the series "Exploring Cosmic Origins with CORE." We forecast the capability to determine key inflationary parameters, to lower the detection limit for the tensor-to-scalar ratio down to the 10−3 level, to chart the landscape of single field slow-roll inflationary models, to constrain the epoch of reheating, thus connecting inflation to the standard radiation-matter dominated Big Bang era, to reconstruct the primordial power spectrum, to constrain the contribution from isocurvature perturbations to the 10−3 level, to improve constraints on the cosmic string tension to a level below the presumptive GUT scale, and to improve the current measurements of primordial non-Gaussianities down to the fNLlocal < 1 level. For all the models explored, CORE alone will improve significantly on the present constraints on the physics of inflation. Its capabilities will be further enhanced by combining with complementary future cosmological observations.

Electron-vibron interactions in charged fullerenes. I. Berry phases.

Abstract: A simple model for electron-vibron interactions on charged fullerenes ${\mathrm{C}}_{60}^{\mathit{n}\mathrm{\ensuremath{-}}}$, n=1,...,5, is solved both at weak and strong couplings. We consider a single ${\mathit{H}}_{\mathit{g}}$ vibrational multiplet interacting with ${\mathit{t}}_{1\mathit{u}}$ electrons. At strong coupling the semiclassical dynamical Jahn-Teller theory is valid. The Jahn-Teller distortions are unimodal for n=1,2,4,5 electrons, and bimodal for 3 electrons. The distortions are quantized as rigid-body pseudorotators which are subject to geometrical Berry phases. These impose ground-state degeneracies and dramatically change zero-point energies. Exact diagonalization shows that the semiclassical level degeneracies and ordering survive well into the weak-coupling regime. At weak coupling, we discover an enhancement factor of 5/2 for the pair binding energies over their classical values. This has potentially important implications for superconductivity in fullerides, and demonstrates the shortcoming of Migdal-Eliashberg theory for molecular crystals.