Islamic Azad University

About: Islamic Azad University is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Population & Adsorption. The organization has 83635 authors who have published 113437 publications receiving 1275049 citations. The organization is also known as: Azad University.

Cytotoxic effect of magnetic iron oxide nanoparticles synthesized via seaweed aqueous extract

Abstract: Magnetic iron oxide nanoparticles (Fe3O4 MNPs) are among the most useful metal nanoparticles for multiple applications across a broad spectrum in the biomedical field, including the diagnosis and treatment of cancer. In previous work, we synthesized and characterized Fe3O4 MNPs using a simple, rapid, safe, efficient, one-step green method involving reduction of ferric chloride solution using brown seaweed (Sargassum muticum) aqueous extract containing hydroxyl, carboxyl, and amino functional groups mainly relevant to polysaccharides, which acts as a potential stabilizer and metal reductant agent. The aim of this study was to evaluate the in vitro cytotoxic activity and cellular effects of these Fe3O4 MNPs. Their in vitro anticancer activity was demonstrated in human cell lines for leukemia (Jurkat cells), breast cancer (MCF-7 cells), cervical cancer (HeLa cells), and liver cancer (HepG2 cells). The cancer cells were treated with different concentrations of Fe3O4 MNPs, and an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay was used to test for cytotoxicity, resulting in an inhibitory concentration 50 (IC50) value of 23.83±1.1 μg/mL (HepG2), 18.75±2.1 μg/mL (MCF-7), 12.5±1.7 μg/mL (HeLa), and 6.4±2.3 μg/mL (Jurkat) 72 hours after treatment. Therefore, Jurkat cells were selected for further investigation. The representative dot plots from flow cytometric analysis of apoptosis showed that the percentages of cells in early apoptosis and late apoptosis were increased. Cell cycle analysis showed a significant increase in accumulation of Fe3O4 MNP-treated cells at sub-G1 phase, confirming induction of apoptosis by Fe3O4 MNPs. The Fe3O4 MNPs also activated caspase-3 and caspase-9 in a time-response fashion. The nature of the biosynthesis and therapeutic potential of Fe3O4 MNPs could pave the way for further research on the green synthesis of therapeutic agents, particularly in nanomedicine, to assist in the treatment of cancer.

Homotopy simulation of nanofluid dynamics from a non-linearly stretching isothermal permeable sheet with transpiration

Abstract: In this article we derive semi-analytical/numerical solutions for transport phenomena (momentum, heat and mass transfer) in a nanofluid regime adjacent to a nonlinearly porous stretching sheet by means of the Homotopy analysis method (HAM). The governing equations are reduced to a nonlinear, coupled, non-similar, ordinary differential equation system via appropriate similarity transformations. This system is solved under physically realistic boundary conditions to compute stream function, velocity, temperature and concentration function distributions. The results of the present study are compared with numerical quadrature solutions employing a shooting technique with excellent correlation. Furthermore the current HAM solutions demonstrate very good correlation with the non-transpiring finite element solutions of Rana and Bhargava (Commun. Nonlinear Sci. Numer. Simul. 17:212–226, 2012). The influence of stretching parameter, transpiration (wall suction/injection) Prandtl number, Brownian motion parameter, thermophoresis parameter and Lewis number on velocity, temperature and concentration functions is illustrated graphically. Transpiration is shown to exert a substantial influence on flow characteristics. Applications of the study include industrial nanotechnological fabrication processes.