Istanbul Technical University

About: Istanbul Technical University is a education organization based out in Istanbul, Turkey. It is known for research contribution in the topics: Fuzzy logic & Large Hadron Collider. The organization has 12889 authors who have published 25081 publications receiving 518242 citations. The organization is also known as: İstanbul Teknik Üniversitesi & Technical University of Istanbul.

Observation of a new χb state in radiative transitions to Y(1S) and Y(2S) at ATLAS

Abstract: The χb(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider at √s=7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb-1, these states are reconstructed through their radiative decays to Υ(1S,2S) with Υ→μ+μ-. In addition to the mass peaks corresponding to the decay modes χb(1P,2P)→Υ(1S)γ, a new structure centered at a mass of 10.530±0.005(stat)±0.009(syst) GeV is also observed, in both the Υ(1S)γ and Υ(2S)γ decay modes. This structure is interpreted as the χb(3P) system.

Accurate and high output impedance current mirror suitable for CMOS current output stages

Abstract: An accurate, very-high-output-resistance active-feedback cascode current mirror has been proposed and compared with a previously reported accurate cascode current mirror. Comparisons have shown that, besides higher accuracy and output resistance, the proposed circuit has no residual error, but has a wider output voltage swing, a much higher PSRR, and an easier and more flexible design.

Benzoxazine-Based Thermosets with Autonomous Self-Healing Ability

Abstract: A self-healing strategy for poly(propylene oxide)s bearing benzoxazine units (PPO-Benz) through supramolecular attractions is described. Poly(propylene oxide) bisamine (PPO) with a molecular wieght of 2000 Da was reacted with formaldehyde and bisphenol A to yield desired PPO-Benz with 12 360 Da. The cross-linked polymer films were then prepared by solvent casting of suitable compositions of PPO-Benz and carboxlic acid containing benzoxazine monomer (Carb-Benz) in chloroform followed by thermal ring-opening reaction of benzoxazine groups at 200 °C. Thermal curing and thermal stability of the film and final products were investigated. It was demonstrated that the self-healing capacity of the films was improved by employing Carb-Benz in the formulation.

Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway

Abstract: Overactivation of PI3K/Akt/mTOR is linked with carcinogenesis and serves a potential molecular therapeutic target in treatment of various cancers. Herein, we report the synthesis of trisubstituted-imidazoles and identified 2-chloro-3-(4, 5-diphenyl-1H-imidazol-2-yl) pyridine (CIP) as lead cytotoxic agent. Naive Base classifier model of in silico target prediction revealed that CIP targets RAC-beta serine/threonine-protein kinase which comprises the Akt. Furthermore, CIP downregulated the phosphorylation of Akt, PDK and mTOR proteins and decreased expression of cyclin D1, Bcl-2, survivin, VEGF, procaspase-3 and increased cleavage of PARP. In addition, CIP significantly downregulated the CXCL12 induced motility of breast cancer cells and molecular docking calculations revealed that all compounds bind to Akt2 kinase with high docking scores compared to the library of previously reported Akt2 inhibitors. In summary, we report the synthesis and biological evaluation of imidazoles that induce apoptosis in breast cancer cells by negatively regulating PI3K/Akt/mTOR signaling pathway.

Measurement of ZZ production in pp collisions at √ = 7 TeV and limits on anomalous ZZZ and ZZγ couplings with the ATLAS detector

Abstract: A measurement of the ZZ production cross section in proton-proton collisions at root s = 7 TeV using data recorded by the ATLAS experiment at the Large Hadron Collider is presented. In a data sample corresponding to an integrated luminosity of 4.6 fb(-1) collected in 2011, events are selected that are consistent either with two Z bosons decaying to electrons or muons or with one Z boson decaying to electrons or muons and a second Z boson decaying to neutrinos. The ZZ((*)) -> l(+)l(-)l'(+)l'(-) and ZZ -> l(+)l(-) nu(nu) over bar cross sections are measured in restricted phase-space regions. These results are then used to derive the total cross section for ZZ events produced with both Z bosons in the mass range 66 to 116 GeV, sigma(tot)(ZZ) = 6.7 +/- 0.7 (stat.) (+0.4)(-0.3) (syst.) +/- 0.3 (lumi.) pb, which is consistent with the Standard Model prediction of 5.89(-0.18)(+0.22) pb calculated at next-to-leading order in QCD. The normalized differential cross sections in bins of various kinematic variables are presented. Finally, the differential event yield as a function of the transverse momentum of the leading Z boson is used to set limits on anomalous neutral triple gauge boson couplings in ZZ production.