Istanbul Technical University

About: Istanbul Technical University is a education organization based out in Istanbul, Turkey. It is known for research contribution in the topics: Fuzzy logic & Large Hadron Collider. The organization has 12889 authors who have published 25081 publications receiving 518242 citations. The organization is also known as: İstanbul Teknik Üniversitesi & Technical University of Istanbul.

A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin κ C as a Compatible Prognostic Marker in Human Solid Tumors

Abstract: Purpose: Although the central role of the immune system for tumor prognosis is generally accepted, a single robust marker is not yet available. Experimental Design: On the basis of receiver operating characteristic analyses, robust markers were identified from a 60-gene B cell–derived metagene and analyzed in gene expression profiles of 1,810 breast cancer; 1,056 non–small cell lung carcinoma (NSCLC); 513 colorectal; and 426 ovarian cancer patients. Protein and RNA levels were examined in paraffin-embedded tissue of 330 breast cancer patients. The cell types were identified with immunohistochemical costaining and confocal fluorescence microscopy. Results: We identified immunoglobulin κ C (IGKC) which as a single marker is similarly predictive and prognostic as the entire B-cell metagene. IGKC was consistently associated with metastasis-free survival across different molecular subtypes in node-negative breast cancer ( n = 965) and predicted response to anthracycline-based neoadjuvant chemotherapy ( n = 845; P Conclusion: Our findings provide IGKC as a novel diagnostic marker for risk stratification in human cancer and support concepts to exploit the humoral immune response for anticancer therapy. It could be validated in several independent cohorts and carried out similarly well in RNA from fresh frozen as well as from paraffin tissue and on protein level by immunostaining. Clin Cancer Res; 18(9); 2695–703. ©2012 AACR.

One-Pot Synthesis of ABC Type Triblock Copolymers via in situ Click [3 + 2] and Diels−Alder [4 + 2] Reactions

Abstract: We report a one-pot synthesis of ABC triblock copolymers of poly(ethylene glycol)− (PEG−) polystyrene− (PS−) poly(methyl methacrylate) (PMMA), and poly(e-caprolactone)− (PCL−) PS−PMMA by combining in situ click [3 + 2] and Diels−Alder [4 + 2] reactions. For this purpose, furan-protected maleimide end-functionalized PMMA, PS with α-anthracene and ω-azide end-functionality, and PEG or PCL with an alkyne end-functional group were reacted in N,N-dimehtylformamide (DMF) for 36 h at 120 °C in order to give the corresponding triblock copolymers. All polymeric precursors with narrow molecular weight distribution and well-defined chain-end functionalities were achieved from living polymerization methods, except PEG. The obtained polymers were characterized by 1H NMR (250 MHz), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC) measurements.

Measurement of inclusive jet and dijet production in pp collisions at root s=7 TeV using the ATLAS detector

Abstract: Inclusive jet and dijet cross sections have been measured in proton-proton collisions at a centre-of-mass energy of 7 TeV using the ATLAS detector at the Large Hadron Collider. The cross sections were measured using jets clustered with the anti-kT algorithm with parameters R=0.4 and R=0.6. These measurements are based on the 2010 data sample, consisting of a total integrated luminosity of 37 inverse picobarns. Inclusive jet double-differential cross sections are presented as a function of jet transverse momentum, in bins of jet rapidity. Dijet double-differential cross sections are studied as a function of the dijet invariant mass, in bins of half the rapidity separation of the two leading jets. The measurements are performed in the jet rapidity range |y|<4.4, covering jet transverse momenta from 20 GeV to 1.5 TeV and dijet invariant masses from 70 GeV to 5 TeV. The data are compared to expectations based on next-to-leading order QCD calculations corrected for non-perturbative effects, as well as to next-to-leading order Monte Carlo predictions. In addition to a test of the theory in a new kinematic regime, the data also provide sensitivity to parton distribution functions in a region where they are currently not well-constrained.