Showing papers by "Istanbul University published in 1988"
Journal Article•
TL;DR: Pathergy test was positive in 6/18 and 5/19 carried HLA-B5, suggesting that the previously established association of HLA -B5 in Behçet's syndrome is mainly true for hospital based populations, and was less commonly positive in milder disease.
Abstract: We conducted a field survey to establish the prevalence of Behcet's syndrome among all the inhabitants aged 10 years or older in a village in northern Turkey. The prevalence of Behcet's syndrome was 19/5,131. There were 13 females and 6 males. None had eye involvement. Pathergy test was positive in 6/18 (33%) and 5/19 carried HLA-B5 (26%), suggesting that the previously established association of HLA-B5 in Behcet's syndrome is mainly true for hospital based populations. Moreover, the pathergy test was less commonly positive in milder disease.
189 citations
TL;DR: Both plasma lipid peroxide levels and erythrocyte susceptibility to lipid peroxidation were significantly increased in Parkinson's disease and the results suggest that ery Throcyte membrane integrity may be impaired in Parkinson't disease.
59 citations
TL;DR: In this article, the suitability of Turkish sulphur olive oil monoester as a diesel fuel substitute has been investigated, and some preliminary laboratory tests concerning the applicability of the fuel oil monoeater as an industrial byproduct such as crude fuel oil has been performed.
Abstract: Esterification of Turkish sulphur olive oil with different types of straight- and branched-chain monohydric alcohols has been investigated. Reaction conditions such as temperature and time have been evaluated, and monoester yield has been determined. As the alcohol component, direct application of an industrial byproduct such as crude fuel oil has been investigated. Finally some preliminary laboratory tests concerning the suitability of the fuel oil monoester as a diesel fuel substitute have been performed.
52 citations
TL;DR: In this paper, the axial ligands of dichloro[tetra(15-crown-5)phthalocyaninato]silicon or -tin have been converted into dihydroxy derivatives by hydrolysis in aqueous Et3N.
Abstract: Group-IV-A phthalocyanines with four crown ether substituents have been prepared from 4′,5′-dicyanobenzo(15-crown-5), 4′,5′-diiminoisoindolino(15-crown-5), or metal-free phthalocyanine and the corresponding metal salts. The axial ligands of dichloro[tetra(15-crown-5)phthalocyaninato]silicon or -tin have been converted into dihydroxy derivatives by hydrolysis in aqueous Et3N. The catalytic effect of H2O-free CaC12 in quinoline is used for the polycondensation of dihydroxysilicon-phthalocyanine to cofacially arrayed polymers. The thermal stability of group-IV-A-metal phthalocyanines is confirmed by the higher initial decomposition points (290–440°) compared to those of the corresponding transition-metal phthalocyanines.
48 citations
TL;DR: Six new compounds from the root extracts of Salvia hypargeia, in addition to the known diterpenoids cryptanol and horminone, showed antibacterial activity, while hypargenin F was also active against Mycobacterium tuberculosis.
Abstract: From the root extracts of Salvia hypargeia, in addition to the known diterpenoids cryptanol and horminone, six new abietane diterpenoids were isolated. The structures of the new and the known compounds were established by spectral data. The new compounds, hypargenins A, B, C, D, and F, showed antibacterial activity, while hypargenin F was also active against Mycobacterium tuberculosis. Hypargenin E did not exhibit antibacterial activity.
46 citations
TL;DR: Human growth hormone treatment cannot make up a deficit in height prognosis already present at diagnosis, but prevents further loss of stature, which is why early diagnosis is important.
46 citations
TL;DR: In this paper, approximate boundary conditions on a sheet simulating an anisotropic thin layer are derived using previously derived general boundary relations, which depend on the concept of distribution and do not require complicated mathematical representations or unproved equivalence principles.
Abstract: Approximate boundary conditions on a sheet simulating an anisotropic thin layer are derived using previously derived general boundary relations. The method depends on the concept of distribution and does not require complicated mathematical representations or unproved equivalence principles.
41 citations
TL;DR: It is concluded that amyloidosis associated with Behçet's disease is a secondary AA amyloidsosis occurring as an intrinsic manifestation of Behçett's disease.
Abstract: The association of amyloidosis with Behcet's disease has infrequently been reported in published works. Twenty four such cases have been observed in the world, of which 12 are from Turkey, including eight of ours. In all our eight cases renal biopsy showed amyloidosis of type AA. Behcet's disease of male preponderance, long duration, complete type, multiple organ involvement, and positive skin pathergy test were the main characteristics of all 24 cases of Behcet's disease with amyloidosis. We conclude that amyloidosis associated with Behcet's disease is a secondary AA amyloidosis occurring as an intrinsic manifestation of Behcet's disease.
36 citations
TL;DR: Two Turkish sibs, products of a second cousin marriage, with tetramelic syndactyly, ectodermal dysplasia, cleft lip and palate, renal anomalies, and mental retardation are reported.
Abstract: Two Turkish sibs, products of a second cousin marriage, with tetramelic syndactyly, ectodermal dysplasia, cleft lip and palate, renal anomalies, and mental retardation are reported. Similarities between these two brothers and previously reported cases and their mode of transmission are discussed.
31 citations
TL;DR: In this paper, a two-dimensional theory of gravity with dynamical metric and torsion in the context of string theory has been studied and the eigenmodes for fluctuations of the solutions of the equations are also investigated.
24 citations
TL;DR: The distributions of the alkaloids colchicine, 2-demethyldemecolcine, 3-demethylcolchicines, demecol cine, and 3- DemethyldEMecolCine in the corms, stems, leaves, flowers, and seeds of COLCHICUM CILICICUM were analysed by HPLC.
Abstract: The distributions of the alkaloids colchicine, 2-demethylcolchicine, 3-demethylcolchicine, demecolcine, 2-demethyldemecolcine, and 3-demethyldemecolcine in the corms, stems, leaves, flowers, and seeds of COLCHICUM CILICICUM were analysed by HPLC. In addition, the alkaloids cornigerine, N-formyl- N-deacetylcolchicine, N-methyl-demecolcine, beta-lumicolchicine, gamma-lumicolchicine, beta-lumidemecolcine, gamma-lumidemecolcine, and N-ethoxycarbonyldemecolcine were identified, the last named being reported for the first time from a COLCHICUM species. The flavones luteolin and apigenin were isolated and benzoic, 2-hydroxy-6-methoxybenzoic, and vanillic acids were also detected.
Journal Article•
TL;DR: Results show that cholesterol feeding leads to the stimulation of hepatic lipid peroxidation as well as impairment of glutathione-related enzyme activities in rats.
Abstract: Liver cholesterol, phospholipid, triglyceride, lipid peroxide and glutathione levels as well as glutathione peroxidase and glutathione transferase activities were determined in rats fed a high-cholesterol (2%, w/w), high-cholic acid (0.5%, w/w) diet for 3 months. Cholesterol feeding caused an increase in hepatic cholesterol and triglyceride levels, but no change was observed in hepatic phospholipid levels. In addition, a significant increase in hepatic lipid peroxide levels and a significant decrease in glutathione peroxidase and glutathione transferase activities have been observed. However, hepatic glutathione content after cholesterol feeding remained unchanged. These results show that cholesterol feeding leads to the stimulation of hepatic lipid peroxidation as well as impairment of glutathione-related enzyme activities in rats.
TL;DR: The root extract of Ruta chalepensis yielded a new alkaloid chaloridone in addition to skimmianine, kokusaginine and graveoline as discussed by the authors.
TL;DR: In this paper, the aerial parts of Lavandula stoechas were elucidated by spectral methods and the compounds identified as longipin-2-ene-7β,9α-diol-1 -one and longipina-2.7β-9α -diol 1 -one 9-monoacetate were identified.
TL;DR: In this article, a low-molecular-weight model polymers with only one phthalocyanine unit (3a, b) were prepared from tetracyanodibenzo-18-crown-6 (2a), where the cyano end groups were partially converted into imido groups during the cyclotetramerization reaction.
Abstract: (18-Crown-6)-bridged phthalocyanine network polymers 4–8 as well as a low-molecular-weight model compounds with only one phthalocyanine unit (3a, b) were prepared from tetracyanodibenzo-18-crown-6 (2a). The cyano end groups were partially converted into imido groups during the cyclotetramerization reaction, as detected from the IR spectra. In order to obtain structurally uniform compounds with the same end groups, the C N groups were hydrolyzed into imido groups with conc. sulfuric acid. The metal-free phthalocyanine polymer 4a was obtained by the reaction of 2a either with hydroquinone or PbO in ethylene glycol. The chlorides of Cu(II), Ni(II), and Co(II) were empolyed in order to synthesize the corresponding metal-phthalocyanine polymer, and Fe(CO)5 was used for the preparation of the Fe-analog 7a. For the preparation of the Co-containing polymer 8a ammonium molybdate has to be added as catalyst. The selectivity of 7a for Rb+ was found to be highest in the heterogeneous phase extraction experiments. Polymers 4–8 are also capable of binding silver from aqueous and methanolic solutions.
TL;DR: The aerial parts of Achillea sintenisii afforded in addition to known compounds a new costunolide, Sintenin whose structure was elucidated by spectral methods as discussed by the authors.
Journal Article•
TL;DR: In this paper, a solution for estimating the time of concentration for a diverging watershed is obtained for estimating a watershed's watershed length, slope, roughness, and rainfall excess.
Abstract: A solution is obtained for estimating the time of concentration for a diverging watershed. A comparison of concentration times for diverging and plane surfaces is made to examine the influence of the degree of divergence for a diverging watershed on the time of concentration. Assuming that the physical characteristics such as watershed length, slope, roughness and rainfall excess are the same, an expression of the ratio of the time of concentration for a diverging surface to that for a plane surface is derived. The expression is solved numerically, and evaluated graphically. The results can be used easily for practical purposes.
TL;DR: Gil-Vernet antireflux procedure has been carried out for Refluxing renal units, yielding a positive outcome in all, with disappearance of refluxing in 94% of the renal units with grade II, III and IV vesicoureteral reflux.
TL;DR: In this paper, the hydrodynamic behavior of two laterally interconnected subchannels under two-phase flow conditions has been studied and the experimental results on void fractions, liquid mass flow rates and pressures in the channels have been compared with the predictions of the COBRA-III-C and COBra-IV subchannel computer codes and in general a reasonable agreement has been obtained.
TL;DR: The prevalence of HLA‐DR2 was 25/50 (50%) among patients with lepromatous leprosy in Turkey and the prevalence of the same alleles among healthy controls was 13/ 50 (26%).
Abstract: Among 50 patients with lepromatous leprosy and borderline lepromatous leprosy in Turkey, the prevalence of HLA-DR2 was 25/50 (50%). The prevalence of the same alleles among 50 healthy controls was 13/50 (26%).
TL;DR: The chloroform extract of the leaves of Onopordon tauricum yielded 10 sesquiterpene lactones, including elamanolide and four new eudesmanolides.
TL;DR: The flavonoid sulphate derivatives are shown to be present in SILYBUM genus for the first time.
Abstract: Flavonolignan compounds have been isolated from the fruits of SILYBUM MARIANUM subsp. ANATOLICUM and kaempferol 3-sulphate and other flavonoid compounds have been isolated from the aerial parts and were identified. The flavonoid sulphate derivatives are shown to be present in SILYBUM genus for the first time.
TL;DR: Parvaquone was used in 13 cattle naturally infected with theileria annulata and 11 were discharged in fairly good condition and two died of tropical theileriosis on the sixth day after commencement of treatment.
Abstract: Parvaquone was used in 13 cattle naturally infected withTheileria annulata. Blood smears and lymph node biopsy smears were taken, stained and examined for the presence of the piroplasm and schizont stages of the parasite respectively. Smears were examined before and on the third, fifth and seventh day after commencement of therapy. Two doses of parvaquone were injected in the neck intramuscularly at 10mg/kg bodyweight at 48 hour intervals. Of the 13 cattle treated 11 were discharged in fairly good condition and two died of tropical theileriosis on the sixth day after commencement of treatment.
TL;DR: A 16-year-old boy came to the authors' dermatology clinic with cutaneous changes on the sun-exposed areas in October 1980 with the diagnosis of Rothmund-Thomson syndrome, but there were some additional, unusual symptoms such as swan neck deformity of the fifth finger and dorsal hyperflexion of the thumb.
Abstract: A 16-year-old boy came to our dermatology clinic with cutaneous changes on the sun-exposed areas in October 1980. On examination, there was a poikilodermatous appearance of the face, ears, neck, forearms, and dorsum of the hands (Figs. 1-3). Dermatoglyphics were absent, and there were palmoplantar keratoses and fissures. The skin of the body was also mildly atrophic and dry. There were atrophic scars on the knees and elbows. Saddle nose was a significant feature (Fig. 1). The patient's hair was normal, but eyebrows and beard Were sparse. His toenails were thick and fragile. Tooth abnormality was also apparent. He was small in stature (152 cm height and 37 kg weight), and his bone age was determined to be 12 by radiologic examination. According to his parents, the first abnormality had begun when he was 2 years old with toenail deformity. Tooth abnormalities developed when he was 7 years old, and the skin changes began to occur in the following years. All these symptoms led us to make the diagnosis of Rothmund-Thomson syndrome, but there were some additional, unusual symptoms such as swan neck deformity of the fifth finger (Fig. 2) and dorsal hyperflexion of the thumb. The most noticeable additional symptom was numerous, yellowish papules localized on the extremities. They were small (1-5 mm), hard, dome-shaped papules (Figs. 3, 4).
TL;DR: The aerial parts of Tanacetum heterotomum were elucidated by spectral methods in this article, enabling the discovery of spiroketalenoletherpolyine and a new sesquiterpene-coumarin ether.
TL;DR: The majority (82.3%) of all cases examined by the Division of Narcotic Drugs Research Laboratories of the Council of Forensic Medicine of Turkey, related to Cannabis products, and heroin represented 16.7% and all other controlled drugs made up the remaining 1%.