Showing papers by "Istanbul University published in 2017"
Aix-Marseille University1, Genentech2, Samsung Medical Center3, Seconda Università degli Studi di Napoli4, Wayne State University5, Pontifícia Universidade Católica do Rio Grande do Sul6, University of California, Los Angeles7, European Institute of Oncology8, Istanbul University9, Seoul National University Bundang Hospital10, University of California, Davis11
TL;DR: Overall survival was significantly longer with atezolizumab in the ITT and PD-L1-expression populations, and overall survival improvement was similar in patients with squamous non-squamous lung cancer.
3,496 citations
TL;DR: The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries, and the contributions of changes in prevalence versus population growth and ageing to the increase.
1,573 citations
TL;DR: The addition of abiraterone acetate and prednisone to androgen‐deprivation therapy significantly increased overall survival and radiographic progression‐free survival in men with newly diagnosed, metastatic, castration‐sensitive prostate cancer.
Abstract: BackgroundAbiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostate cancer We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer MethodsIn this double-blind, placebo-controlled, phase 3 trial, we randomly assigned 1199 patients to receive either androgen-deprivation therapy plus abiraterone acetate (1000 mg daily, given once daily as four 250-mg tablets) plus prednisone (5 mg daily) (the abiraterone group) or androgen-deprivation therapy plus dual placebos (the placebo group) The two primary end points were overall survival and radiographic progression-free survival ResultsAfter a median follow-up of 304 months at a planned interim analysis (after 406 patients had died), the median overall survival was significantly longer in the abiraterone group than in the placebo group (not rea
1,457 citations
Hammersmith Hospital1, Cancer Research UK2, Imperial College London3, University College London4, Royal North Shore Hospital5, Flinders University6, Monash University7, Ain Shams University8, French Institute of Health and Medical Research9, Charité10, University of Oldenburg11, Magna Græcia University12, Catholic University of the Sacred Heart13, University of Verona14, Tokyo Medical University15, Aichi Medical University16, King Abdulaziz Medical City17, Seoul National University Hospital18, Keimyung University19, University of Ulsan20, Inje University21, Universidad Francisco de Vitoria22, University of Amsterdam23, VU University Amsterdam24, Istanbul University25, University of Florence26, Conquest Hospital27, University of Exeter28, Anglia Ruskin University29, Emory University30, United States Department of Veterans Affairs31, University of Washington32, Stony Brook University33, Canterbury Christ Church University34, Duke University35, Hospital Clínico San Carlos36, Complutense University of Madrid37
TL;DR: Coronary revascularization guided by iFR was noninferior to revascularizations guided by FFR with respect to the risk of major adverse cardiac events at 1 year.
Abstract: BackgroundCoronary revascularization guided by fractional flow reserve (FFR) is associated with better patient outcomes after the procedure than revascularization guided by angiography alone. It is unknown whether the instantaneous wave-free ratio (iFR), an alternative measure that does not require the administration of adenosine, will offer benefits similar to those of FFR. MethodsWe randomly assigned 2492 patients with coronary artery disease, in a 1:1 ratio, to undergo either iFR-guided or FFR-guided coronary revascularization. The primary end point was the 1-year risk of major adverse cardiac events, which were a composite of death from any cause, nonfatal myocardial infarction, or unplanned revascularization. The trial was designed to show the noninferiority of iFR to FFR, with a margin of 3.4 percentage points for the difference in risk. ResultsAt 1 year, the primary end point had occurred in 78 of 1148 patients (6.8%) in the iFR group and in 83 of 1182 patients (7.0%) in the FFR group (difference i...
672 citations
University of Erlangen-Nuremberg1, University of Florence2, Utrecht University3, Paris Descartes University4, UCL Institute of Child Health5, Istanbul University6, Charles University in Prague7, University of Bonn8, VU University Amsterdam9, University of Paris10, University College London11, University of Grenoble12, University of Freiburg13, University of Greifswald14, University of Tübingen15, University of Ulm16, University of Lisbon17, University of Barcelona18, HCL Technologies19, Ludwig Maximilian University of Munich20
TL;DR: In patients with drug‐resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the second most common lesion in both groups.
Abstract: BackgroundDetailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. MethodsWe report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). ResultsThe onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of...
518 citations
TL;DR: A rapid search in PubMed shows that using "flow cytometry immunology" as a search term yields more than 68 000 articles, the first of which is not about lymphocytes as mentioned in this paper.
Abstract: The marriage between immunology and cytometry is one of the most stable and productive in the recent history of science. A rapid search in PubMed shows that, as of July 2017, using “flow cytometry immunology” as a search term yields more than 68 000 articles, the first of which, interestingly, is not about lymphocytes. It might be stated that, after a short engagement, the exchange of the wedding rings between immunology and cytometry officially occurred when the idea to link fluorochromes to monoclonal antibodies came about. After this, recognizing different types of cells became relatively easy and feasible not only by using a simple fluorescence microscope, but also by a complex and sometimes esoteric instrument, the flow cytometer that is able to count hundreds of cells in a single second, and can provide repetitive results in a tireless manner. Given this, the possibility to analyse immune phenotypes in a variety of clinical conditions has changed the use of the flow cytometer, which was incidentally invented in the late 1960s to measure cellular DNA by using intercalating dyes, such as ethidium bromide. The epidemics of HIV/AIDS in the 1980s then gave a dramatic impulse to the technology of counting specific cells, since it became clear that the quantification of the number of peripheral blood CD4+ T cells was crucial to follow the course of the infection, and eventually for monitoring the therapy. As a consequence, the development of flow cytometers that had to be easy-to-use in all clinical laboratories helped to widely disseminate this technology. Nowadays, it is rare to find an immunological paper or read a conference abstract in which the authors did not use flow cytometry as the main tool to dissect the immune system and identify its fine and complex functions. Of note, recent developments have created the sophisticated technology of mass cytometry, which is able to simultaneously identify dozens of molecules at the single cell level and allows us to better understand the complexity and beauty of the immune system.
454 citations
University of Leicester1, University of Maryland, College Park2, Goddard Space Flight Center3, Pennsylvania State University4, University College London5, Los Alamos National Laboratory6, California Institute of Technology7, Tel Aviv University8, University of Maryland, Baltimore County9, INAF10, University of Warwick11, Agenzia Spaziale Italiana12, Istanbul University13, Southern Utah University14, Clemson University15, National Science Foundation16, Universities Space Research Association17, University of Copenhagen18, Stockholm University19, Aoyama Gakuin University20
TL;DR: In this paper, ultraviolet and x-ray observations from the Nuclear Spectroscopic Telescope Array (NSTA) of the binary neutron star merger GW170817 were used to detect a high mass (≈0.03 solar masses) wind-driven outflow with moderate electron fraction.
Abstract: With the first direct detection of merging black holes in 2015, the era of gravitational wave (GW) astrophysics began. A complete picture of compact object mergers, however, requires the detection of an electromagnetic (EM) counterpart. We report ultraviolet (UV) and x-ray observations by Swift and the Nuclear Spectroscopic Telescope Array of the EM counterpart of the binary neutron star merger GW170817. The bright, rapidly fading UV emission indicates a high mass (≈0.03 solar masses) wind-driven outflow with moderate electron fraction (Ye ≈ 0.27). Combined with the x-ray limits, we favor an observer viewing angle of ≈30° away from the orbital rotation axis, which avoids both obscuration from the heaviest elements in the orbital plane and a direct view of any ultrarelativistic, highly collimated ejecta (a γ-ray burst afterglow).
373 citations
University of Leicester1, Goddard Space Flight Center2, University of Maryland, College Park3, Pennsylvania State University4, University College London5, Los Alamos National Laboratory6, California Institute of Technology7, Tel Aviv University8, University of Maryland, Baltimore County9, INAF10, University of Warwick11, Agenzia Spaziale Italiana12, Istanbul University13, Southern Utah University14, Clemson University15, National Science Foundation16, Universities Space Research Association17, University of Copenhagen18, Stockholm University19, Aoyama Gakuin University20
TL;DR: Ultraviolet and x-ray observations of a binary neutron star merger show a hot kilonova but no jet along the line of sight, which avoids both obscuration from the heaviest elements in the orbital plane and a direct view of any ultrarelativistic, highly collimated ejecta.
Abstract: With the first direct detection of merging black holes in 2015, the era of gravitational wave (GW) astrophysics began. A complete picture of compact object mergers, however, requires the detection of an electromagnetic (EM) counterpart. We report ultraviolet (UV) and X-ray observations by Swift and the Nuclear Spectroscopic Telescope ARray (NuSTAR) of the EM counterpart of the binary neutron star merger GW170817. The bright, rapidly fading ultraviolet emission indicates a high mass ($\approx0.03$ solar masses) wind-driven outflow with moderate electron fraction ($Y_{e}\approx0.27$). Combined with the X-ray limits, we favor an observer viewing angle of $\approx 30^{\circ}$ away from the orbital rotation axis, which avoids both obscuration from the heaviest elements in the orbital plane and a direct view of any ultra-relativistic, highly collimated ejecta (a gamma-ray burst afterglow).
308 citations
TL;DR: In this paper, the Higgs boson mass was measured in the H → ZZ → 4l (l = e, μ) decay channel and the signal strength modifiers for individual Higgs production modes were also measured.
Abstract: Properties of the Higgs boson are measured in the H → ZZ → 4l (l = e, μ) decay channel. A data sample of proton-proton collisions at $ \sqrt{s}=13 $ TeV, collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 35.9 fb$^{−1}$ is used. The signal strength modifier μ, defined as the ratio of the observed Higgs boson rate in the H → ZZ → 4l decay channel to the standard model expectation, is measured to be μ = 1.05$_{− 0.17}^{+ 0.19}$ at m$_{H}$ = 125.09 GeV, the combined ATLAS and CMS measurement of the Higgs boson mass. The signal strength modifiers for the individual Higgs boson production modes are also measured. The cross section in the fiducial phase space defined by the requirements on lepton kinematics and event topology is measured to be 2. 92$_{− 0.44}^{+ 0.48}$ (stat)$_{− 0.24}^{+ 0.28}$ (syst)fb, which is compatible with the standard model prediction of 2.76 ± 0.14 fb. Differential cross sections are reported as a function of the transverse momentum of the Higgs boson, the number of associated jets, and the transverse momentum of the leading associated jet. The Higgs boson mass is measured to be m$_{H}$ = 125.26 ± 0.21 GeV and the width is constrained using the on-shell invariant mass distribution to be Γ$_{H}$ < 1.10 GeV, at 95% confidence level.
290 citations
VU University Medical Center1, University of Crete2, North Shore-LIJ Health System3, Dresden University of Technology4, Karolinska Institutet5, New York University6, University of São Paulo7, University of Groningen8, National and Kapodistrian University of Athens9, University of Manchester10, University of Calgary11, Lupus Foundation of America12, University of Paris13, University of Pécs14, Semmelweis University15, Utrecht University16, University of Padua17, Charité18, University of Düsseldorf19, University of Birmingham20, Medical University of Graz21, Université catholique de Louvain22, University College London23, University of Cambridge24, University of Mainz25, Paris Descartes University26, Rio de Janeiro State University27, University of Paris-Sud28, Monash University29, University of Pisa30, Istanbul University31, University of Santo Tomas32, Johns Hopkins University33, Tel Aviv University34, Medical University of Vienna35, University of Brescia36, University of Toronto37, University of Porto38, University of Southern Denmark39, Veterans Health Administration40, Hairmyres Hospital41, National Institutes of Health42
TL;DR: An international task force of 60 specialists and patient representatives agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions, which provides a framework for testing different definitions of remission against long-term outcomes.
Abstract: Objectives Treat-to-target recommendations have identified ‘remission’ as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE. Methods An international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting. The level for agreement was set at 90%. Results The task force agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions: 1. Definitions of remission will be worded as follows: remission in SLE is a durable state characterised by …………………. (reference to symptoms, signs, routine labs). 2. For defining remission, a validated index must be used, for example, clinical systemic lupus erythematosus disease activity index (SLEDAI)=0, British Isles lupus assessment group (BILAG) 2004 D/E only, clinical European consensus lupus outcome measure (ECLAM)=0; with routine laboratory assessments included, and supplemented with physician9s global assessment. 3. Distinction is made between remission off and on therapy: remission off therapy requires the patient to be on no other treatment for SLE than maintenance antimalarials; and remission on therapy allows patients to be on stable maintenance antimalarials, low-dose corticosteroids (prednisone ≤5 mg/day), maintenance immunosuppressives and/or maintenance biologics. The task force also agreed that the most appropriate outcomes (dependent variables) for testing the prognostic value (construct validity) of potential remission definitions are: death, damage, flares and measures of health-related quality of life. Conclusions The work of this international task force provides a framework for testing different definitions of remission against long-term outcomes.
243 citations
TL;DR: In this article, a Monte Carlo method (CMSY) was used for estimating fisheries reference points from catch, resilience and qualitative stock status information on data-limited stocks, which gave good predictions of the maximum intrinsic rate of population increase r, unexploited stock size k and maximum sustainable yield MSY when validated against simulated data with known parameter values.
Abstract: This study presents a Monte Carlo method (CMSY) for estimating fisheries reference points from catch, resilience and qualitative stock status information on data-limited stocks. It also presents a Bayesian state-space implementation of the Schaefer production model (BSM), fitted to catch and biomass or catch-per-unit-of-effort (CPUE) data. Special emphasis was given to derive informative priors for productivity, unexploited stock size, catchability and biomass from population dynamics theory. Both models gave good predictions of the maximum intrinsic rate of population increase r, unexploited stock size k and maximum sustainable yield MSY when validated against simulated data with known parameter values. CMSY provided, in addition, reasonable predictions of relative biomass and exploitation rate. Both models were evaluated against 128 real stocks, where estimates of biomass were available from full stock assessments. BSM estimates of r, k and MSY were used as benchmarks for the respective CMSY estimates and were not significantly different in 76% of the stocks. A similar test against 28 data-limited stocks, where CPUE instead of biomass was available, showed that BSM and CMSY estimates of r, k and MSY were not significantly different in 89% of the stocks. Both CMSY and BSM combine the production model with a simple stock–recruitment model, accounting for reduced recruitment at severely depleted stock sizes.
TL;DR: It is demonstrated that iPSCs can generate YS macrophage‐like cells (iMacs) that differentiate into functional tissue‐resident macrophages‐ like cells upon receiving organ‐specific cues, thus providing a platform for modeling tissue‐ resident macrophAGE precursors.
TL;DR: In this paper, the authors present an evaluation system to help users assess the suitability of the available inventories for different types of earthquake-induced landslide studies and model development, as well as the underlying characteristics of landslide size, topographic slope, roughness, local relief, distance to streams, peak ground acceleration and peak ground velocity.
Abstract: Earthquake-induced landslide (EQIL) inventories are essential tools to extend our knowledge of the relationship between earthquakes and the landslides they can trigger. Regrettably, such inventories are difficult to generate and therefore scarce, and the available ones differ in terms of their quality and level of completeness. Moreover, access to existing EQIL inventories is currently difficult because there is no centralized database. To address these issues, we compiled EQIL inventories from around the globe based on an extensive literature study. The database contains information on 363 landslide-triggering earthquakes and includes 66 digital landslide inventories. To make these data openly available, we created a repository to host the digital inventories that we have permission to redistribute through the U.S. Geological Survey ScienceBase platform. It can grow over time as more authors contribute their inventories. We analyze the distribution of EQIL events by time period and location, more specifically breaking down the distribution by continent, country and mountain region. Additionally, we analyze frequency distributions of EQIL characteristics, such as the approximate area affected by landslides, total number of landslides, maximum distance from fault rupture zone, and distance from epicenter when the fault plane location is unknown. For the available digital EQIL inventories, we examine the underlying characteristics of landslide size, topographic slope, roughness, local relief, distance to streams, peak ground acceleration, peak ground velocity, and Modified Mercalli Intensity. Also, we present an evaluation system to help users assess the suitability of the available inventories for different types of EQIL studies and model development.
TL;DR: This review focuses on ER stress and UPR signaling mechanisms, and their potential roles in female and male reproductive physiopathology involving in menstrual cycle changes, gametogenesis, preimplantation embryo development, implantation and placentation, labor, endometriosis, pregnancy complications and preterm birth as well as reproductive system tumorigenesis.
Abstract: The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts directly or indirectly with several cell organelles i.e., Golgi bodies, mitochondria and proteasomes. The ER is usually associated with large numbers of attached ribosomes. During evolution, ER developed as the specific cellular site of synthesis, folding, modification and trafficking of secretory and cell-surface proteins. The ER is also the major intracellular calcium storage compartment that maintains cellular calcium homeostasis. During the production of functionally effective proteins, several ER-specific molecular steps sense quantity and quality of synthesized proteins as well as proper folding into their native structures. During this process, excess accumulation of unfolded/misfolded proteins in the ER lumen results in ER stress, the homeostatic coping mechanism that activates an ER-specific adaptation program, (the unfolded protein response; UPR) to increase ER-associated degradation of structurally and/or functionally defective proteins, thus sustaining ER homeostasis. Impaired ER homeostasis results in aberrant cellular responses, contributing to the pathogenesis of various diseases. Both female and male reproductive tissues undergo highly dynamic cellular, molecular and genetic changes such as oogenesis and spermatogenesis starting in prenatal life, mainly controlled by sex-steroids but also cytokines and growth factors throughout reproductive life. These reproductive changes require ER to provide extensive protein synthesis, folding, maturation and then their trafficking to appropriate cellular location as well as destroying unfolded/misfolded proteins via activating ER-associated degradation mediated proteasomes. Many studies have now shown roles for ER stress/UPR signaling cascades in the endometrial menstrual cycle, ovarian folliculogenesis and oocyte maturation, spermatogenesis, fertilization, pre-implantation embryo development and pregnancy and parturition. Conversely, the contribution of impaired ER homeostasis by severe/prolong ER stress-mediated UPR signaling pathways to several reproductive tissue pathologies including endometriosis, cancers, recurrent pregnancy loss and pregnancy complications associated with pre-term birth have been reported. This review focuses on ER stress and UPR signaling mechanisms, and their potential roles in female and male reproductive physiopathology involving in menstrual cycle changes, gametogenesis, preimplantation embryo development, implantation and placentation, labor, endometriosis, pregnancy complications and preterm birth as well as reproductive system tumorigenesis.
TL;DR: Response surface methodology (RSM) and artificial neural networks (ANN) were evaluated and compared in order to decide which method was the most appropriate to predict and optimize total phenolic content (TPC) and oleuropein yields in olive tree leaf extracts, obtained after solvent-free microwave-assisted extraction (SFMAE).
Abstract: Response surface methodology (RSM) and artificial neural networks (ANN) were evaluated and compared in order to decide which method was the most appropriate to predict and optimize total phenolic content (TPC) and oleuropein yields in olive tree leaf (Oleaeuropaea) extracts, obtained after solvent-free microwave-assisted extraction (SFMAE). The SFMAE processing conditions were: microwave irradiation power 250-350 W, extraction time 2-3 min, and the amount of sample 5-10 g. Furthermore, the antioxidant and antimicrobial activities of the olive leaf extracts, obtained under optimal extraction conditions, were assessed by several in vitro assays. ANN had better prediction performance for TPC and oleuropein yields compared to RSM. The optimum extraction conditions to recover both TPC and oleuropein were: irradiation power 250 W, extraction time 2 min, and amount of sample 5 g, independent of the method used for prediction. Under these conditions, the maximal yield of oleuropein (0.060 ± 0.012 ppm) was obtained and the amount of TPC was 2.480 ± 0.060 ppm. Moreover, olive leaf extracts obtained under optimum SFMAE conditions showed antibacterial activity against S.aureus and S.epidermidis, with a minimum inhibitory concentration (MIC) value of 1.25 mg/mL.
Hacettepe University1, University of Toronto2, University of Paris-Sud3, University College London4, University of California, San Diego5, German Center for Pediatric and Adolescent Rheumatology6, Charité7, Istanbul University8, Utrecht University9, Boston Children's Hospital10, Harvard University11, Alberta Children's Hospital12
TL;DR: The novel approach integrated traditional methods of evidence synthesis with expert consensus, web-based decision tools and innovative statistical methods to develop and validate diagnostic criteria forCryopyrin-associated periodic syndrome.
Abstract: Cryopyrin-associated periodic syndrome (CAPS) is a rare, heterogeneous disease entity associated with NLRP3 gene mutations and increased interleukin-1 (IL-1) secretion. Early diagnosis and rapid initiation of IL-1 inhibition prevent organ damage. The aim of the study was to develop and validate diagnostic criteria for CAPS. An innovative process was followed including interdisciplinary team building, item generation: review of CAPS registries, systematic literature review, expert surveys, consensus conferences for item refinement, item reduction and weighting using 1000Minds decision software. Resulting CAPS criteria were tested in large cohorts of CAPS cases and controls using correspondence analysis. Diagnostic models were explored using sensitivity analyses. The international team included 16 experts. Systematic literature and registry review identified 33 CAPS-typical items; the consensus conferences reduced these to 14. 1000Minds exercises ranked variables based on importance for the diagnosis. Correspondence analysis determined variables consistently associated with the diagnosis of CAPS using 284 cases and 837 controls. Seven variables were significantly associated with CAPS (p<0.001). The best diagnosis model included: Raised inflammatory markers (C-reactive protein/serum amyloid A) plus ≥two of six CAPS-typical symptoms: urticaria-like rash, cold-triggered episodes, sensorineural hearing loss, musculoskeletal symptoms, chronic aseptic meningitis and skeletal abnormalities. Sensitivity was 81%, specificity 94%. It performed well for all CAPS subtypes and regardless of NLRP3 mutation. The novel approach integrated traditional methods of evidence synthesis with expert consensus, web-based decision tools and innovative statistical methods and may serve as model for other rare diseases. These criteria will enable a rapid diagnosis for children and adults with CAPS.
TL;DR: Zirconia‐reinforced glass‐ceramic revealed higher mean translucency and biaxial flexural strength than resin nanoceramic, feldspathic ceramic, lithium disilicate ceramic, and dual‐network ceramic.
Abstract: Statement of problem Achieving natural tooth appearance with sufficient mechanical strength is one of the most challenging issues of computer-assisted design and computer-assisted manufacturing (CAD-CAM) materials. However, limited evidence is available regarding their optical and mechanical properties for proper and evidence-based material selection in clinical practice. Purpose The purpose of this in vitro study was to assess and compare the translucency and biaxial flexural strength of 5 monolithic CAD-CAM restorative materials. Material and methods Disk-shaped specimens (n=30) of each material (Lava Ultimate [LU], Vita Enamic [VE], Vitablocs Mark II [VMII], Vita Suprinity [VS], and IPS e.max CAD [IPS]) with a diameter of 12 mm and a thickness of 1.2 ±0.05 mm were prepared. A spectrophotometer was used to measure the translucency parameter. The specimens were then subjected to a biaxial flexure test using 3 balls and loaded with a piston in a universal testing machine at a cross-head speed of 0.5 mm/min until failure occurred (International Organization for Standardization standard 6872). Weibull statistics were used to evaluate the characteristic strength and reliability of each material. Chemical compositions were analyzed using an energy dispersive spectrometer, and microstructural analysis was conducted using scanning electron microscopy. Data were analyzed using 1-way ANOVA and the Tukey honest significant difference test (α=.05). Results Significant differences were found among the materials concerning translucency and biaxial flexural strength ( P Conclusions Based on the results of the present study, zirconia-reinforced glass-ceramic revealed higher mean translucency and biaxial flexural strength than resin nanoceramic, feldspathic ceramic, lithium disilicate ceramic, and dual-network ceramic.
TL;DR: There was no difference in the incidence and severity of chronic pain at 6 months in patients undergoing thoracotomy versus thoracoscopy and none of the preoperative psychosocial measurements were associated with chronic pain after thoracic surgery.
Abstract: Background:The goal of this study was to detect the predictors of chronic pain at 6 months after thoracic surgery from a comprehensive evaluation of demographic, psychosocial, and surgical factors.Methods:Thoracic surgery patients were enrolled 1 week before surgery and followed up 6 months postsurg
Newcastle University1, Charité2, Hospital Clínico San Carlos3, Universidad Camilo José Cela4, University of Manchester5, Erasmus University Rotterdam6, Karolinska University Hospital7, Boston Children's Hospital8, University of Leeds9, University of Sheffield10, Newcastle upon Tyne Hospitals NHS Foundation Trust11, University of Genoa12, Semmelweis University13, Ludwig Maximilian University of Munich14, Military Medical Academy15, Istanbul University16, Hacettepe University17
TL;DR: 12 specific recommendations for YP with jRMD focused on transitional care included: high-quality, multidisciplinary care starting in early adolescence; the integral role of a transition co-ordinator; transition policies and protocols; efficient communications; transfer documentation.
Abstract: To develop standards and recommendations for transitional care for young people (YP) with juvenile-onset rheumatic and musculoskeletal diseases (jRMD). The consensus process involved the following: (1) establishing an international expert panel to include patients and representatives from multidisciplinary teams in adult and paediatric rheumatology; (2) a systematic review of published models of transitional care in jRMDs, potential standards and recommendations, strategies for implementation and tools to evaluate services and outcomes; (3) setting the framework, developing the process map and generating a first draft of standards and recommendations; (4) further iteration of recommendations; (5) establishing consensus recommendations with Delphi methodology and (6) establishing standards and quality indicators. The final consensus derived 12 specific recommendations for YP with jRMD focused on transitional care. These included: high-quality, multidisciplinary care starting in early adolescence; the integral role of a transition co-ordinator; transition policies and protocols; efficient communications; transfer documentation; an open electronic-based platform to access resources; appropriate training for paediatric and adult healthcare teams; secure funding to continue treatments and services into adult rheumatology and the need for increased evidence to inform best practice. These consensus-based recommendations inform strategies to reach optimal outcomes in transitional care for YP with jRMD based on available evidence and expert opinion. They need to be implemented in the context of individual countries, healthcare systems and regulatory frameworks.
TL;DR: In this article, the authors investigated similarities and differences between van der Waals fluids and charged AdS black holes for the expansion of the T-P plane and determined the cooling-heating regions.
Abstract: In this paper, we study Joule–Thomson effects for charged AdS black holes. We obtain inversion temperatures and curves. We investigate similarities and differences between van der Waals fluids and charged AdS black holes for the expansion. We obtain isenthalpic curves for both systems in the T–P plane and determine the cooling–heating regions.
Tel Aviv Sourasky Medical Center1, University of Buenos Aires2, Leipzig University3, University of Milan4, Favaloro University5, Tel Aviv University6, Istanbul University7, L V Prasad Eye Institute8, Chiang Mai University9, University of Paris10, University of Sydney11, University of Coimbra12, University of Perugia13, Monterrey Institute of Technology and Higher Education14
TL;DR: In this paper, the authors investigated OCT biomarkers for DME treated by intravitreal dexamethasone (DEX) implant and found that OCT is useful in identifying various imaging findings in DME.
TL;DR: This review discusses pathophysiology of the neonatal HIE and its treatment options, including hypothermia, melatonin, allopurinol, topiramate, erythropoietin, N-acetylcyctein, magnesium sulphate and xenon.
Abstract: Introduction: Hypoxic ischemic encephalopathy (HIE) is the most important reason for morbidity and mortality in term-born infants. Understanding pathophysiology of the brain damage is essential for the early detection of patients with high risk for HIE and development of strategies for their treatments.Areas covered: This review discusses pathophysiology of the neonatal HIE and its treatment options, including hypothermia, melatonin, allopurinol, topiramate, erythropoietin, N-acetylcyctein, magnesium sulphate and xenon.Expert commentary: Several clinical studies have been performed in order to decrease the risk of brain injury due to difficulties in the early diagnosis and treatment, and to develop strategies for better long-term outcomes. Although currently standard treatment methods include therapeutic hypothermia for neonates with moderate to severe HIE, new supportive options are needed to enhance neuroprotective effects of the hypothermia, which should aim to reduce production of the free rad...
TL;DR: Accumulating evidence shows that biological agents such as anti-tumor necrosis factor agents, tocilizumab and rituximab could be used effectively in refractory cases and the mortality seems to be decreasing in recent years.
Abstract: Purpose of reviewTakayasu arteritis has long been considered as an uncommon disease, rather specific to the Far-East; however recent surveys show that the disease can be seen in all ethnicities around the world with increasing prevalence rates. Nowadays, it would not be fair to consider Takayasu art
Mustafa Kemal University1, Istanbul University2, Marmara University3, İnönü University4, Başkent University5, Yüzüncü Yıl University6, Dicle University7, Recep Tayyip Erdoğan University8, Uludağ University9, Gazi University10, Zonguldak Karaelmas University11, Maltepe University12, Selçuk University13, Bahçeşehir University14, Süleyman Demirel University15, Mersin University16, Imam Muhammad ibn Saud Islamic University17, Eskişehir Osmangazi University18
TL;DR: Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium, which was associated with higher Rankin score.
Abstract: Background Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients Methods All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution Results Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (166% versus 278%) The most frequent symptoms were headache (894%) and visual field defects (289%) in men, and headache (861%) and epileptic seizures (268%) in women Gynecological factors comprised the largest group in women, in particular puerperium (183%) Prothrombotic conditions (264%), mainly methylenetetrahydrofolate reductase mutation (63%) and Factor V Leiden mutation (51%), were the most common etiologies in both genders 81% of patients had infection-associated and 52% had malignancy-related etiology that was significantly higher in men and older age group Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score Epileptic seizures had no effect on prognosis Conclusions Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium Oral contraceptive use was not a prevalent risk factor in our cohort Malignancy, older age, and hemorrhagic infarcts had worse outcome
International Agency for Research on Cancer1, University of Hawaii2, Carlos III Health Institute3, Mayo Clinic4, National University of Singapore5, Harvard University6, University of Chile7, Brigham and Women's Hospital8, Boston University9, University of Hong Kong10, University of Oslo11, University of Southern California12, City of Hope National Medical Center13, Ninewells Hospital14, Queen Mary University of London15, The Royal Marsden NHS Foundation Trust16, Aga Khan University17, University of Malaya18, Nofer Institute of Occupational Medicine19, Gifu University20, University of Western Australia21, University of Melbourne22, Cancer Council Victoria23, Istanbul University24, Marmara University25, Utrecht University26, Isfahan University of Medical Sciences27, Jackson State University28, University College London29, Asan Medical Center30, University of the Witwatersrand31, Cancer Care Ontario32, Princess Margaret Cancer Centre33, Technion – Israel Institute of Technology34, Cairo University35, University of London36
TL;DR: Cross-sectional differences in MD by age and menopausal status in over 11,000 breast-cancer-free women aged 35–85 years are examined, suggesting that younger ages may be the more critical periods for lifestyle modifications aimed at breast density and breast cancer risk reduction.
Abstract: BACKGROUND: Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women worldwide is not known. METHODS AND FINDINGS: We examined cross-sectional differences in MD by age and menopausal status in over 11,000 breast-cancer-free women aged 35-85 years, from 40 ethnicity- and location-specific population groups across 22 countries in the International Consortium on Mammographic Density (ICMD). MD was read centrally using a quantitative method (Cumulus) and its square-root metrics were analysed using meta-analysis of group-level estimates and linear regression models of pooled data, adjusted for body mass index, reproductive factors, mammogram view, image type, and reader. In all, 4,534 women were premenopausal, and 6,481 postmenopausal, at the time of mammography. A large age-adjusted difference in percent MD (PD) between post- and premenopausal women was apparent (-0.46 cm [95% CI: -0.53, -0.39]) and appeared greater in women with lower breast cancer risk profiles; variation across population groups due to heterogeneity (I2) was 16.5%. Among premenopausal women, the √PD difference per 10-year increase in age was -0.24 cm (95% CI: -0.34, -0.14; I2 = 30%), reflecting a compositional change (lower dense area and higher non-dense area, with no difference in breast area). In postmenopausal women, the corresponding difference in √PD (-0.38 cm [95% CI: -0.44, -0.33]; I2 = 30%) was additionally driven by increasing breast area. The study is limited by different mammography systems and its cross-sectional rather than longitudinal nature. CONCLUSIONS: Declines in MD with increasing age are present premenopausally, continue postmenopausally, and are most pronounced over the menopausal transition. These effects were highly consistent across diverse groups of women worldwide, suggesting that they result from an intrinsic biological, likely hormonal, mechanism common to women. If cumulative breast density is a key determinant of breast cancer risk, younger ages may be the more critical periods for lifestyle modifications aimed at breast density and breast cancer risk reduction.
National Institutes of Health1, Manchester Academic Health Science Centre2, Wellcome Trust Sanger Institute3, University of Cincinnati Academic Health Center4, Cincinnati Children's Hospital Medical Center5, Hacettepe University6, Emory University7, Cleveland Clinic8, University of Utah9, Albert Einstein College of Medicine10, Stanford University11, Federal University of São Paulo12, University of Toronto13, University of Saskatchewan14, University College London15, University of Barcelona16, German Center for Pediatric and Adolescent Rheumatology17, Charité18, RWTH Aachen University19, Central Manchester University Hospitals NHS Foundation Trust20, University of Pittsburgh21, Icahn School of Medicine at Mount Sinai22, The Centre for Applied Genomics23, Karolinska Institutet24, University of Granada25, University of Liège26, Pompeu Fabra University27, Istanbul University28
TL;DR: The hypothesis that sJIA is a unique disease process and argues for a different classification framework is supported and research to improve sJia therapy should target its unique genetics and specific pathophysiological pathways.
Abstract: Objectives Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA (sJIA) is a rare form of JIA characterised by systemic inflammation. sJIA is distinguished from other forms of JIA by unique clinical features and treatment responses that are similar to autoinflammatory diseases. However, approximately half of children with sJIA develop destructive, long-standing arthritis that appears similar to other forms of JIA. Using genomic approaches, we sought to gain novel insights into the pathophysiology of sJIA and its relationship with other forms of JIA.
Methods We performed a genome-wide association study of 770 children with sJIA collected in nine countries by the International Childhood Arthritis Genetics Consortium. Single nucleotide polymorphisms were tested for association with sJIA. Weighted genetic risk scores were used to compare the genetic architecture of sJIA with other JIA subtypes.
Results The major histocompatibility complex locus and a locus on chromosome 1 each showed association with sJIA exceeding the threshold for genome-wide significance, while 23 other novel loci were suggestive of association with sJIA. Using a combination of genetic and statistical approaches, we found no evidence of shared genetic architecture between sJIA and other common JIA subtypes.
Conclusions The lack of shared genetic risk factors between sJIA and other JIA subtypes supports the hypothesis that sJIA is a unique disease process and argues for a different classification framework. Research to improve sJIA therapy should target its unique genetics and specific pathophysiological pathways.
TL;DR: In this paper, gas separation performance of 6FDA-DAM-ZIF-11 mixed matrix membranes (MMMs) with various ZIF11 percentages (0, 10, 20, 30) were investigated.
TL;DR: The primary goals of treatment are to eliminate active disease, to normalize joint function, to preserve normal growth and to prevent long-term joint damage.
Abstract: Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis. Seropositive polyarticular juvenile idiopathic arthritis, an analogue of adult rheumatoid arthritis, is seen in less than 10% of paediatric patients. Seronegative polyarticular juvenile idiopathic arthritis, an entity more specific for childhood, appears with widespread large- and small-joint involvement. Enthesitis-related arthritis is a separate disease subtype, characterized by enthesitis and asymmetric lower-extremity arthritis. This disease subtype represents the childhood form of adult spondyloarthropathies, with human leukocyte antigen-B27 positivity and uveitis but commonly without axial skeleton involvement. Juvenile psoriatic arthritis is characterized by a psoriatic rash, accompanied by arthritis, nail pitting and dactylitis. Disease complications can vary from growth retardation and osteoporosis secondary to treatment and disease activity, to life-threatening macrophage activation syndrome with multi-organ insufficiency. With the advent of new therapeutics over the past 15 years, there has been a marked improvement in juvenile idiopathic arthritis treatment and long-term outcome, without any sequelae. The treatment of juvenile idiopathic arthritis patients involves teamwork, including an experienced paediatric rheumatologist, an ophthalmologist, an orthopaedist, a paediatric psychiatrist and a physiotherapist. The primary goals of treatment are to eliminate active disease, to normalize joint function, to preserve normal growth and to prevent long-term joint damage. Timely and aggressive treatment is important to provide early disease control. The first-line treatment includes disease-modifying anti-rheumatic drugs (methotrexate, sulphasalazine, leflunomide) in combination with corticosteroids, used in different dosages and routes (oral, intravenous, intra-articular). Intra-articular application of steroids seems to be an effective treatment modality, especially in monoarthritis. Biological agents should be added in the treatment of unresponsive patients. Anti-tumour necrosis factor agents (etanercept, infliximab, adalimumab), anti-interleukin-1 agents (anakinra, canakinumab), anti- interleukin-6 agents (tocilizumab) and T-cell regulatory agents (abatacept) have been shown to be safe and effective in childhood patients. Recent studies reported sustained reduction in joint damage with even complete clinical improvement in paediatric patients, compared to previous data.
Heidelberg University1, Hacettepe University2, Boston Children's Hospital3, Çukurova University4, Hannover Medical School5, University of Isfahan6, Istanbul University7, Charité8, Vilnius University9, Jagiellonian University Medical College10, Ege University11, University of Gaziantep12, Gdańsk Medical University13, Başkent University14, University of Milan15, Mario Negri Institute for Pharmacological Research16, Medical University of Warsaw17, Memorial Hospital of South Bend18, Aristotle University of Thessaloniki19, Gazi University20, Dubai Hospital21
TL;DR: It is suggested that responsiveness to initial IIS and detection of a hereditary podocytopathy are prognostic indicators of favorable and poor long-term outcome, respectively, in children with steroid-resistant nephrotic syndrome.
Abstract: We investigated the value of genetic, histopathologic, and early treatment response information in prognosing long-term renal outcome in children with primary steroid-resistant nephrotic syndrome. From the PodoNet Registry, we obtained longitudinal clinical information for 1354 patients (disease onset at >3 months and <20 years of age): 612 had documented responsiveness to intensified immunosuppression (IIS), 1155 had kidney biopsy results, and 212 had an established genetic diagnosis. We assessed risk factors for ESRD using multivariate Cox regression models. Complete and partial remission of proteinuria within 12 months of disease onset occurred in 24.5% and 16.5% of children, respectively, with the highest remission rates achieved with calcineurin inhibitor-based protocols. Ten-year ESRD-free survival rates were 43%, 94%, and 72% in children with IIS resistance, complete remission, and partial remission, respectively; 27% in children with a genetic diagnosis; and 79% and 52% in children with histopathologic findings of minimal change glomerulopathy and FSGS, respectively. Five-year ESRD-free survival rate was 21% for diffuse mesangial sclerosis. IIS responsiveness, presence of a genetic diagnosis, and FSGS or diffuse mesangial sclerosis on initial biopsy as well as age, serum albumin concentration, and CKD stage at onset affected ESRD risk. Our findings suggest that responsiveness to initial IIS and detection of a hereditary podocytopathy are prognostic indicators of favorable and poor long-term outcome, respectively, in children with steroid-resistant nephrotic syndrome. Children with multidrug-resistant sporadic disease show better renal survival than those with genetic disease. Furthermore, histopathologic findings may retain prognostic relevance when a genetic diagnosis is established.
TL;DR: Proximate composition, protein, lipid and ash content, fatty acid content and nutritional value of three macroalgae (Ascophyllum nodosum, Fucus vesiculosus and Bifurcaria bifurcate) were studied and it was found that the three seaweeds are a rich source of K, Mn and Ca.
Abstract: Proximate composition (moisture, protein, lipid and ash content) and nutritional value (fatty acid, amino acid and mineral profile) of three macroalgae (Ascophyllum nodosum, Fucus vesiculosus and Bifurcaria bifurcate) were studied. Chemical composition was significantly (p < 0.001) different among the three seaweeds. In this regard, the B. bifurcata presented the highest fat content (6.54% of dry matter); whereas, F. vesiculosus showed the highest protein level (12.99% dry matter). Regarding fatty acid content, the polyunsaturated fatty acids (PUFAs) were the most abundant followed by saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs). On the other hand, the three seaweeds are a rich source of K (from 3781.35 to 9316.28 mg/100 g), Mn (from 8.28 to 1.96 mg/100 g), Na (from 1836.82 to 4575.71 mg/100 g) and Ca (from 984.73 to 1160.27 mg/100 g). Finally, the most abundant amino acid was glutamic acid (1874.47–1504.53 mg/100 dry matter), followed by aspartic acid (1677.01–800.84 mg/100 g dry matter) and alanine (985.40–655.73 mg/100 g dry matter).