Showing papers by "Istanbul University published in 2022"
TL;DR: In this article , a case series of patients diagnosed with an ocular inflammatory event within 14 days following COVID-19 vaccination was collected from 40 centres over a 3 month period in 2021.
Abstract: Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine's immunogenicity and safety, especially in patients with pre-existing inflammatory conditions.Multinational case series of patients diagnosed with an ocular inflammatory event within 14 days following COVID-19 vaccination collected from 40 centres over a 3 month period in 2021.Seventy patients presented with ocular inflammatory events within 14 days following COVID-19 vaccination. The mean age was 51 years (range, 19-84 years). The most common events were anterior uveitis (n = 41, 58.6%), followed by posterior uveitis (n = 9, 12.9%) and scleritis (n = 7, 10.0%). The mean time to event was 5 days and 6 days (range, 1-14 days) after the first and second dose of vaccine, respectively. Among all patients, 36 (54.1%) had a previous history of ocular inflammatory event. Most patients (n = 48, 68.6%) were managed with topical corticosteroids. Final vision was not affected in 65 (92.9%), whereas 2 (2.9%) and 3 (4.3%) had reduction in visual acuity reduced by ≤3 lines and > 3 lines, respectively. Reported complications included nummular corneal lesions (n = 1, 1.4%), cystoid macular oedema (n = 2, 2.9%) and macular scarring (n = 2, 2.9%).Ocular inflammatory events may occur after COVID-19 vaccination. The findings are based on a temporal association that does not prove causality. Even in the possibility of a causal association, most of the events were mild and had a good visual outcome.
48 citations
TL;DR: In this article, the authors investigated the antecedents and outcomes of consumer engagement through AR apps and suggested a new conceptual model to examine how consumer engagement is shaped via AR apps, which eventually leads to a positive attitude towards brand and brand usage intent.
41 citations
TL;DR: Among participants vaccinated by CoronaVac inactive SARS-CoV-2 or BNT162b2 messenger RNA (mRNA) COVID-19 (Pfizer-BioNTech) vaccine, healthy children under 18 and patients under 21 with an at least 1-year follow-up period in their department for a childhood-onset rheumatic disease were included into a cross-sectional study as discussed by the authors .
Abstract: Considering the concerns regarding the coronavirus disease-2019 (COVID-19) vaccine safety among pediatric patients with inflammatory rheumatic diseases (IRD) due to a lack of data, an urgent need for studies evaluating safety profiles of vaccines emerged.Among participants vaccinated by CoronaVac inactive SARS-CoV-2 or BNT162b2 messenger RNA (mRNA) COVID-19 (Pfizer-BioNTech) vaccine, healthy children under 18 and patients under 21 with an at least 1-year follow-up period in our department for a childhood-onset rheumatic disease were included into this cross-sectional study.Overall, 246 subjects (141 [57.3%] females) (biologic group: 43, non-biologic group: 180, healthy control group: 23) were eligible for the study. The median age was 15.34 (12.02-20.92) years. The most common adverse events were fatigue (n = 68, 27.6%), headache (n = 44, 17.9%), myalgia (n = 38, 15.4%), arthralgia (n = 38, 15.4%), and fever (n = 35, 14.2%). Only 3 subjects (2 patients with familial Mediterranean fever, and one healthy child) were considered to experienced serious adverse events, since they required hospitalization. Local reactions were seen in 20 (8.13%), and 27 patients (12.1%) had disease flares within 1 month after the vaccines. Although it was significantly higher in those who received the BNT162b2 mRNA vaccine (P < .001), there was no significant relationship between adverse event frequency and age, gender, the existing diseases, ongoing treatment regimens and pre-vaccination COVID-19 histories.Although immunogenicity studies for efficacy of the vaccines and long-term follow-up studies for adverse events monitoring are required, our study indicates an acceptable safety profile of COVID-19 vaccines and encourages children with IRD to be vaccinated.
32 citations
TL;DR: A series of bis-and tetrakis-1,2,3-triazole derivatives were synthesized using copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry in 73-95% yield as mentioned in this paper.
23 citations
TL;DR: The role of 68Ga-DOTA-FAPI-04 PET/CT in imaging of primary, metastatic, and recurrent cancers was investigated in this paper , which showed that FAPI molecules can be used for radionuclide therapy in patients with metastatic disease and unresponsive to other treatments.
Abstract: Cancer-associated fibroblasts, which are densely found in tumor tissue, express high levels of fibroblast activation protein (FAP), and FAP inhibitors (FAPIs) labeled with radionuclides can be used in the diagnosis and treatment of cancer. In this study, the role of 68Ga-DOTA-FAPI-04 PET/CT in imaging of primary, metastatic, and recurrent cancers was investigated.A total of 42 patients (16 females, 26 males; mean age, 58.5 years; range, 31-84 years) with 22 different types of malignant diseases were included in the study. 68Ga-DOTA-FAPI-04 PET/CT imaging was performed 1 to 7 days after 18F-FDG PET/CT. Pathological uptake levels in primary tumoral lesions, lymph nodes, skeletal system, liver, peritoneal surfaces, and other body parts were compared between 2 PET/CTs. In addition, physiological uptake levels of 18F-FDG and 68Ga-FAPI were defined measuring the liver, thoracic aorta, gluteal muscle activities, and uterus activity in female patients.Of the 42 patients in the study group, 33 patients were included for staging, 8 patients for restaging, and 1 patient for evaluation of treatment response. 68Ga-DOTA-FAPI-04 PET/CT showed intense uptake in 94.2% of primary tumoral lesions. In patients with multiple myeloma, 18F-FDG uptake in the bone marrow was significantly higher than 68Ga-FAPI uptake, whereas in gastric signet ring cell tumors, 68Ga-FAPI uptake was found to be significantly higher than 18F-FDG uptake. It was observed that 68Ga-DOTA-FAPI-04 PET/CT detected bone, liver, and peritoneum metastases with higher sensitivity and accuracy compared 18F-FDG PET/CT.The preliminary findings of this study showed that 68Ga-DOTA-FAPI-04 PET/CT can contribute to the diagnostic process in solid tumors. Especially in malignancies with mild uptake on 18F-FDG PET/CT, it stands out in diagnosis, staging, and restaging. It is also predicted that FAPI molecules can be used for radionuclide therapy in patients with metastatic disease and unresponsive to other treatments showing intense uptake on 68Ga-DOTA-FAPI-04 PET/CT.
22 citations
TL;DR: In this article, the Fourier Transform and Gradient-weighted Class Activation Mapping methods were applied to the input images together and type-based activation sets were created with three different ResNet models before the Softmax method.
19 citations
TL;DR: In this article, a biocomposite film based on soy protein isolate (SPI) and sunflower oil (SO) was fabricated using freeze drying (FDM) as an innovative approach to formulate a fairly easy-to-apply way, moreover, results were compared with the classic film production method (CM).
18 citations
TL;DR: In this article , a biocomposite film based on soy protein isolate (SPI) and sunflower oil (SO) was fabricated using freeze drying (FDM) as an innovative approach to formulate a fairly easy-to-apply way, moreover, results were compared with the classic film production method (CM).
18 citations
TL;DR: In this paper, a fluorescent probe bearing triphenylamine, thiophene and thiosemicarbazide (TPA-TSC) was developed, and its distinct features were investigated.
16 citations
TL;DR: In this paper, sol-gel based TiO2 nanoparticles (NPs) were doped by Cu(II), and the surface of cotton fabric was coated with Cu-doped NPs to develop self-cleaning and antibacterial properties.
16 citations
TL;DR: In this paper, the microalgae Haematococcus pluvialis, a freshwater species of Chlorophyta with a high capacity to synthesize astaxanthin, was bioaugmented into an aerobic MBR to investigate its potential on treatment of antibiotics in wastewater, reducing membrane biofouling and impact on the microbial community structure.
TL;DR: The FACET for F orward-A perture C MS E x T ension as mentioned in this paper is a very forward detector for the high-luminosity era of the Large Hadron Collider to search for long-lived particles.
Abstract: A bstract We describe a proposal to add a set of very forward detectors to the CMS experiment for the high-luminosity era of the Large Hadron Collider to search for beyond the standard model long-lived particles, such as dark photons, heavy neutral leptons, axion-like particles, and dark Higgs bosons. The proposed subsystem is called FACET for F orward- A perture C MS E x T ension, and will be sensitive to any particles that can penetrate at least 50 m of magnetized iron and decay in an 18 m long, 1 m diameter vacuum pipe. The decay products will be measured in detectors using identical technology to the planned CMS Phase-2 upgrade.
TL;DR: In this paper , a proposal for a novel integrated Brayton cycle, supercritical plant, trans critical plant and organic Rankine cycle-based power systems for multi-generation applications is presented and analyzed thermodynamically.
TL;DR: In this paper, lead, cadmium, arsenic and mercury levels in 36 samples of infant formula were determined with ICP-MS and the estimated daily intake (EDI), target hazard quotient (THQ) and hazard index (HI) were calculated.
TL;DR: In this paper , lead, cadmium, arsenic and mercury levels in 36 samples of infant formula were determined with ICP-MS and the estimated daily intake (EDI), target hazard quotient (THQ) and hazard index (HI) were calculated.
TL;DR: A series of novel indole-based hydrazide-hydrazone derivatives were synthesized and evaluated for their AChE and BuChE inhibitory activities and a relationship between biological, electronic, and physicochemical qualifications of the title compounds was determined.
TL;DR: In this article, reduced graphene oxide (rGO) was used for detecting a synthetic fungicide as a propamocarb (PM) pesticide in a cucumber sample with high sensitivity in the concentration range of (1-5) μM within a 1-minute cycle.
TL;DR: In this paper, a glassy carbon/multi-walled carbon nanotubes/polyethyleneimine (GC/MWCNTs/PEI) electrode coated with gold nanoparticles (AuNPs) was used for the differential pulse voltammetric (DPV) detection of explosives.
TL;DR: In this paper , a bench-scale electrodialysis (ED) was used to recover acid and water from diluted waste acid liquors in the aluminum anodizing process.
TL;DR: In this paper , the relationship between titanium doping amount and magnetic heating performance of magnetite (Fe3O4) was investigated based on the Néel relaxation mechanism, and it was observed that the induced RF magnetic field for SiO2-coated (Fe0.97,Ti0.03 and 0.05) nanoparticles caused an increase in temperature difference (ΔT) which reached up to 22 °C in 10 min.
Abstract: The study was based on understanding the relationship between titanium (Ti) doping amount and magnetic heating performance of magnetite (Fe3O4). Superparamagnetic nanosized Ti-doped magnetite ((Fe1−x,Tix)3O4; x = 0.02, 0.03 and 0.05) particles were synthesized by sol-gel technique. In addition to (Fe1−x,Tix)3O4 nanoparticles, SiO2 coated (Fe1−x,Tix)3O4 nanoparticles were produced as core-shell structures to understand the effects of silica coating on the magnetic properties of nanoparticles. Moreover, the magnetic properties were associated with the Néel relaxation mechanism due to the magnetic heating ability of single-domain state nanoparticles. In terms of results, it was observed that the induced RF magnetic field for SiO2 coated (Fe0.97,Ti0.03)3O4 nanoparticles caused an increase in temperature difference (ΔT), which reached up to 22 °C in 10 min. The ΔT values of SiO2 coated (Fe0.97,Ti0.03)3O4 nanoparticles were very close to the values of uncoated Fe3O4 nanoparticles.
TL;DR: In this article, a chitosan/functionalized-SWCNT-COOH was prepared to separate boron (as boric acid) from aqueous solutions.
James Hutton Institute1, Spanish National Research Council2, University of Strasbourg3, University of Turin4, Sapienza University of Rome5, State University of Library Studies and Information Technologies6, Polytechnic University of Valencia7, Istanbul University8, Sofia University9, Canadian Real Estate Association10, University of Copenhagen11, Ukrainian National Forestry University12, University of Toronto13
TL;DR: In this paper, the authors present a conceptual framework to evaluate the cost-effectiveness of tree planting for water quality benefits in payments for ecosystem services (PES) schemes in Europe.
Abstract: The evaluation of the cost-effectiveness of Payments for ecosystem services (PES) in fostering positive environmental outcomes has been central to the scientific debate on their implementation. PES cost-effectiveness can be affected by a myriad of environmental, institutional and socio-economic factors operating at different spatial and temporal scales. Moreover, it can be affected by synergies and trade-offs in the provision of ecosystem services (ES). Planting trees is increasingly considered an effective measure to provide water-related ES. It can enhance watershed services such as nutrient retention, erosion control, stream flow regulation, protection against extreme events (e.g., floods and landslides), and lead to a permanent change in land use, replacing agricultural activities that give rise to diffuse pollution. Very few studies currently exist on the cost-effectiveness of tree planting for water quality benefits PES schemes in Europe. Including both review and research elements, this paper highlights challenges in undertaking such assessments. It develops a conceptual framework to help underpin future studies, with its application to three case studies in Denmark explored. Particular attention is given to the estimation of environmental effectiveness in the provision of water quality services and the importance of co-benefits. In the case where we exclude co-benefits from the analysis, the financial cost-effectiveness is always above zero, with central estimates (without discounting environmental improvements) of €10/Kg N, and €0.36 to €0.50/mg pesticide. Once co-benefits are accounted for, however, the social cost-effectiveness is negative (except for under the low estimates) as the value of the co-benefits exceeds the costs, with central estimates of -€28/Kg N, and -€0.34 to -€0.23/mg pesticide. The paper discusses the implications and lessons for PES cost-effectiveness analysis, and identifies research gaps. Increased knowledge of forest water benefits and the cost-effectiveness of woodlands for water schemes would help underpin future incentives to enhance the provision of these ES.
TL;DR: In this paper , the authors reviewed the interventions applied to the caregivers of cancer patients and examined the effects of these interventions on the preparedness to care, and found that the interventions aimed at increasing readiness among the caregivers are important during the illness period for both patients and their caregivers.
Abstract: Preparedness for caregiving could balance the negative impacts of caregiving. The interventions aimed at increasing readiness among the caregivers are important during the illness period for both patients and their caregivers.The aims of this study were to review the interventions applied to the caregivers of cancer patients and to examine the effects of these interventions on the preparedness to care.The ScienceDirect, Scopus, CENTRAL, Web of Science, MEDLINE, and PubMed were searched for relevant studies published between 2000 and 2020. The methodological quality was assessed using the Quality Assessment Tool for Quantitative Studies. The statistical analyses were performed using the Comprehensive Meta-Analysis software version 3.0. The publication bias was assessed using the Egger test, for funnel plots.Eleven studies were selected for the meta-analysis, including those about psychoeducation programs (n = 5), education programs (n = 3), supportive programs (n = 2), and a self-care support program for the caregivers (n = 1). The methodological quality assessment revealed 2 studies as "strong." The results indicated an increase in the caregivers' preparedness to care after the interventions. The subgroup analysis revealed that the programs with higher ratios of female caregivers were more effective.The interventions applied to the family caregivers can exert beneficial effects on caregivers' preparedness to care. Nonetheless, future studies should focus on methodological issues, such as randomization and blinding.Nurse-driven interventions may be used as a useful strategy to improve the preparedness to care among the caregivers of cancer patients. The male caregivers should be closely followed by healthcare professionals for knowledge and support needs.
TL;DR: In this article, the powder coatings market, application processes, required characteristics of the MDF substrate, technological developments and recent studies are extensively given in the context of powder-coating applications.
TL;DR: In this article, the virulence gene contents, biofilm formation, antibiotic susceptibility and clonal relationships of enterococci present in pre-enriched Boza samples were determined.
Abstract: Bacterial microbiota of directly studied and pre-enriched Boza samples were investigated by metagenomic analysis. Virulence gene contents, biofilm formation, antibiotic susceptibility and clonal relationships of enterococci present in pre-enriched Boza samples were determined. Chemical properties of the samples were also investigated. Although directly studied samples showed a dominance by Lactococcus, Lactobacillus, Leuconostoc, and Streptococcus. NGS upon pre-enrichment of the same Boza samples demonstrated a dominance by Lactococcus, Enterococcus, Escherichia/Shigella, Bacillus, and Lactobacillus. All enterococci were identified as Enterococcus faecium and none of them was positive for vanA, vanB, vanC1, vanD, vanE, vanG, agg, gelE, efaAfs, cylA, ace, hyl, cob, cylB, and cylM genes. However, efaAfm, ccf, cpd, and esp genes were detected in the strains. Only one strain formed biofilm and seven strains showed low adherence. E. faecium strains were resistant to rifampin and erythromycin. PFGE revealed 54–100% clonal relationships of E. faecium strains. Percent acidity of Boza samples were 0.14%–0.51%, pH was 3.00–4.07, protein content was 0.35–1.23 mg/100 mg, total sugar content was 9.64–19.21 mg/100 mg Boza, crude ash content was 0.05–0.18 mg/100 mg dry sample, total dry matter was 13.79–28.04 mg/100 mg. Our results indicate to importance of the dynamics nature of microbial communities involved in Boza fermentation and virulence properties of enterococci.
TL;DR: In this paper , the colorimetric response of the Schiff base receptors in DMSO was investigated before and after the addition of an equivalent amount of each anion to evaluate the anion recognition properties.
TL;DR: In this article , a novel thermoelectric module is proposed, which is composed of four different materials, two of which are costly but show high performance at low temperature, while the other two are cheap but show low performance at room temperature.
TL;DR: This review highlights the recent developments in identifying novel molecules that regulate the activities of the core clock proteins and discusses virtual screening-based methods using the crystal structures of coreclock proteins for the discovery of small molecules that regulates the circadian rhythm.
Abstract: The circadian rhythms are physiological, biochemical, and behavioral oscillations that cycle every 24 hours to anticipate the daily changes in the external environment. Disruption of the circadian clock in mammals results in increased susceptibility to different types of diseases such as metabolic, mood and sleep disorders and cancer. To this end, different approaches have been taken to find small molecules that have the potential to correct the disrupted circadian clock. In this review, we highlight the recent developments in identifying novel molecules that regulate the activities of the core clock proteins. Finally, we discuss virtual screening-based methods using the crystal structures of core clock proteins for the discovery of small molecules that regulate the circadian rhythm.
TL;DR: In this article , the authors investigated the relationship between tissue stiffness detected in kidney elastography and interstitial fibrosis observed in kidney biopsy and found a significant correlation between the presence of fibrosis detected by biopsy, and elastograph outcomes (p = .046, r = .192).
Abstract: Kidney interstitial fibrosis is an important risk factor for the progression of chronic kidney disease. Kidney elastography is a noninvasive imaging modality that might be used to assess tissue fibrosis. In this study, we aimed to investigate the relationship between tissue stiffness detected in kidney elastography and interstitial fibrosis observed in kidney biopsy.Patients who were hospitalized in a tertiary care university hospital with a kidney biopsy indication were included in this study. In all patients, the transverse and sagittal elastography measurements were made using a sonoelastography device before the biopsy. The total histological score was calculated.Fifty-seven native kidney patients with proteinuria were included in the study. Patients were divided into two groups according to the presence (n = 6) and absence of fibrosis (n = 51) as detected by kidney biopsy. A significant correlation was found between the presence of fibrosis detected by biopsy and elastography outcomes (p = .046, r = .192). A significant correlation was found between the urea and creatinine levels and transverse elastography measurements (p = .036, r = .240). No correlation was observed between the transverse elastography measurements and total histological score consisting of glomerular, vascular, and tubular scores (r = .006, p = .967).The findings of our study suggest a significant relationship between the elastography measurements and interstitial fibrosis. Because of the high negative predictive value (91%), we suggest that elastography should mainly be used as an exclusion test for the presence of fibrosis. We also believe that elastography may be useful to evaluate the fibrosis status in kidney diseases.