Institution
Istituto Italiano di Tecnologia
Facility•Genoa, Italy•
About: Istituto Italiano di Tecnologia is a facility organization based out in Genoa, Italy. It is known for research contribution in the topics: Humanoid robot & Robot. The organization has 4561 authors who have published 14595 publications receiving 437558 citations. The organization is also known as: Italian Institute of Technology & IIT.
Topics: Humanoid robot, Robot, Graphene, iCub, Population
Papers published on a yearly basis
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01 Jan 2017
135 citations
TL;DR: This work focuses on the molecular mechanisms involved, interacting partners, role of these signaling events in the action of antipsychotics, psychostimulants, and antidepressants as well as involvement in pathophysiology of schizophrenia, bipolar disorder, and Parkinson’s disease.
Abstract: Brain dopamine receptors have been prefered targets for numerous pharmacological compounds developed for the treatment of various neuropsychiatric disorders. Recent discovery that D2 dopamine receptors, in addition to cAMP pathways, can engage also in Akt/GSK3 signaling cascade provided a new framework to understand intracellular signaling mechanisms involved in dopamine-related behaviors and pathologies. Here we review a recent progress in understanding the role of Akt, GSK3 and related signaling molecules in dopamine receptor signaling and functions. Particularly, we focus on the molecular mechanisms involved, interacting partners, role of these signaling events in the action of antipsychotics, psychostimulants and antidepressants as well as involvement in pathophysiology of schizophrenia, bipolar disorder and Parkinson’s disease. Further understanding of the role of Akt/GSK3 signaling in dopamine receptor functions could provide novel targets for pharmacological interventions in dopamine-related disorders.
134 citations
TL;DR: The first selective and potent TAAR1 partial agonist, RO5203648, was reported in this paper, which showed high affinity and potency at TAAR 1, high selectivity versus other targets, and favorable pharmacokinetic properties.
134 citations
TL;DR: The synthesis and characterization of highly elastomeric poly(glycerol sebacate)-co-polyethylene glycol (PGS-co-PEG) block copolymers with controlled water uptake characteristics are reported, which results in almost 15-fold increase in water uptake capacity of PGS, and improves its mechanical stability under dynamic loading conditions.
134 citations
TL;DR: In this article, the authors present a study on the hydrolysis of N, N -dimethylformamide, correlating how pH changes related to its degradation affect the crystallization of MAPbI 3−x Cl x perovskite films.
134 citations
Authors
Showing all 4601 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Marc G. Caron | 173 | 674 | 99802 |
| Paolo Vineis | 134 | 1088 | 86608 |
| Michele Parrinello | 133 | 637 | 94674 |
| Alex J. Barker | 132 | 1273 | 84746 |
| Tomaso Poggio | 132 | 608 | 88676 |
| Shuai Liu | 129 | 1095 | 80823 |
| Giacomo Rizzolatti | 117 | 298 | 97242 |
| Yehezkel Ben-Ari | 110 | 459 | 44293 |
| Daniele Piomelli | 104 | 505 | 49009 |
| Bruno Scrosati | 103 | 580 | 66572 |
| Wolfgang J. Parak | 102 | 469 | 43307 |
| Liberato Manna | 98 | 494 | 44780 |
| Muhammad Imran | 94 | 3053 | 51728 |
| Ole Isacson | 93 | 345 | 30460 |
| Luigi Ambrosio | 93 | 761 | 39688 |