Institution
Istituto Italiano di Tecnologia
Facility•Genoa, Italy•
About: Istituto Italiano di Tecnologia is a facility organization based out in Genoa, Italy. It is known for research contribution in the topics: Humanoid robot & Robot. The organization has 4561 authors who have published 14595 publications receiving 437558 citations. The organization is also known as: Italian Institute of Technology & IIT.
Topics: Humanoid robot, Robot, Graphene, iCub, Population
Papers published on a yearly basis
Papers
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Swiss Federal Laboratories for Materials Science and Technology1, University of Manchester2, Karolinska Institutet3, University College Dublin4, University of Castilla–La Mancha5, University of Trieste6, Istituto Italiano di Tecnologia7, University of Toulouse8, Centre national de la recherche scientifique9
TL;DR: Three physical-chemical properties of GBMs have been defined by the GRAPHENE Flagship Project of the European Union for the unequivocal classification of these materials (see grid).
Abstract: Graphing graphene: Because the naming of graphene-based materials (GBMs) has led to confusion and inconsistency, a classification approach is necessary. Three physical-chemical properties of GBMs have been defined by the GRAPHENE Flagship Project of the European Union for the unequivocal classification of these materials (see grid).
348 citations
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TL;DR: A molecular temperature probe based on the thermal decomposition of a thermo-sensitive molecule, namely, azobis[N-(2-carboxyethyl)-2-methylpropionamidine], which demonstrated the AMF triggered distance-dependent release of the drug in a cytotoxicity assay on KB cancer cells.
Abstract: Local heating can be produced by iron oxide nanoparticles (IONPs) when exposed to an alternating magnetic field (AMF). To measure the temperature profile at the nanoparticle surface with a subnanometer resolution, here we present a molecular temperature probe based on the thermal decomposition of a thermo-sensitive molecule, namely, azobis[N-(2-carboxyethyl)-2-methylpropionamidine]. Fluoresceineamine (FA) was bound to the azo molecule at the IONP surface functionalized with poly(ethylene glycol) (PEG) spacers of different molecular weights. Significant local heating, with a temperature increase up to 45 °C, was found at distances below 0.5 nm from the surface of the nanoparticle, which decays exponentially with increasing distance. Furthermore, the temperature increase was found to scale linearly with the applied field at all distances. We implemented these findings in an AMF-triggered drug release system in which doxorubicin was covalently linked at different distances from the IONP surface bearing the s...
342 citations
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TL;DR: It is demonstrated that FUS regulates circRNA biogenesis by binding the introns flanking the back-splicing junctions and that this control can be reproduced with artificial constructs.
Abstract: The RNA-binding protein FUS participates in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Here we report that FUS controls back-splicing reactions leading to circular RNA (circRNA) production. We identified circRNAs expressed in in vitro-derived mouse motor neurons (MNs) and determined that the production of a considerable number of these circRNAs is regulated by FUS. Using RNAi and overexpression of wild-type and ALS-associated FUS mutants, we directly correlate the modulation of circRNA biogenesis with alteration of FUS nuclear levels and with putative toxic gain of function activities. We also demonstrate that FUS regulates circRNA biogenesis by binding the introns flanking the back-splicing junctions and that this control can be reproduced with artificial constructs. Most circRNAs are conserved in humans and specific ones are deregulated in human-induced pluripotent stem cell-derived MNs carrying the FUSP525L mutation associated with ALS.
342 citations
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TL;DR: The molecular design of DNA-AuNP probes, with the DNA strands immobilized on top of the PEG-based passivation layer, results in nearly unaltered enzymatic activity toward immobilized heteroduplexes compared to substrates free in solution, which may significantly advance the use of microRNAs as biomarkers in the clinical praxis.
Abstract: DNA–gold nanoparticle probes are implemented in a simple strategy for direct microRNA (miRNA) quantification. Fluorescently labeled DNA-probe strands are immobilized on PEGylated gold nanoparticles (AuNPs). In the presence of target miRNA, DNA–RNA heteroduplexes are formed and become substrate for the endonuclease DSN (duplex-specific nuclease). Enzymatic hydrolysis of the DNA strands yields a fluorescence signal due to diffusion of the fluorophores away from the gold surface. We show that the molecular design of our DNA–AuNP probes, with the DNA strands immobilized on top of the PEG-based passivation layer, results in nearly unaltered enzymatic activity toward immobilized heteroduplexes compared to substrates free in solution. The assay, developed in a real-time format, allows absolute quantification of as little as 0.2 fmol of miR-203. We also show the application of the assay for direct quantification of cancer-related miR-203 and miR-21 in samples of extracted total RNA from cell cultures. The possibi...
341 citations
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TL;DR: It is demonstrated that depositing the HTM within an insulating mesoporous "buffer layer" comprised of Al2O3 nanoparticles prevents the metal electrode migration while allowing for precise control of theHTM thickness, which enables an improvement in the solar cell fill factor and prevents degradation of the device after 350 h of operation.
Abstract: Hybrid perovskites represent a new paradigm for photovoltaics, which have the potential to overcome the performance limits of current technologies and achieve low cost and high versatility. However, an efficiency drop is often observed within the first few hundred hours of device operation, which could become an important issue. Here, we demonstrate that the electrode’s metal migrating through the hole transporting material (HTM) layer and eventually contacting the perovskite is in part responsible for this early device degradation. We show that depositing the HTM within an insulating mesoporous “buffer layer” comprised of Al2O3 nanoparticles prevents the metal electrode migration while allowing for precise control of the HTM thickness. This enables an improvement in the solar cell fill factor and prevents degradation of the device after 350 h of operation.
335 citations
Authors
Showing all 4601 results
Name | H-index | Papers | Citations |
---|---|---|---|
Marc G. Caron | 173 | 674 | 99802 |
Paolo Vineis | 134 | 1088 | 86608 |
Michele Parrinello | 133 | 637 | 94674 |
Alex J. Barker | 132 | 1273 | 84746 |
Tomaso Poggio | 132 | 608 | 88676 |
Shuai Liu | 129 | 1095 | 80823 |
Giacomo Rizzolatti | 117 | 298 | 97242 |
Yehezkel Ben-Ari | 110 | 459 | 44293 |
Daniele Piomelli | 104 | 505 | 49009 |
Bruno Scrosati | 103 | 580 | 66572 |
Wolfgang J. Parak | 102 | 469 | 43307 |
Liberato Manna | 98 | 494 | 44780 |
Muhammad Imran | 94 | 3053 | 51728 |
Ole Isacson | 93 | 345 | 30460 |
Luigi Ambrosio | 93 | 761 | 39688 |