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Institution

Istituto Italiano di Tecnologia

FacilityGenoa, Italy
About: Istituto Italiano di Tecnologia is a facility organization based out in Genoa, Italy. It is known for research contribution in the topics: Humanoid robot & Robot. The organization has 4561 authors who have published 14595 publications receiving 437558 citations. The organization is also known as: Italian Institute of Technology & IIT.
Topics: Humanoid robot, Robot, Graphene, iCub, Population


Papers
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Journal ArticleDOI
TL;DR: Tactile sensors provide robots with the ability to interact with humans and the environment with great accuracy, yet technical challenges remain for electronic-skin systems to reach human-level performance.
Abstract: Tactile sensors provide robots with the ability to interact with humans and the environment with great accuracy, yet technical challenges remain for electronic-skin systems to reach human-level performance.

216 citations

Journal ArticleDOI
TL;DR: It is shown that overexpression of wild-type human APP (APP695), or APP harboring the Swedish double mutation (APPswe) triggers increased ryanodine receptor (RyR) expression and enhances RyR-mediated ER Ca2+ release in SH-SY5Y neuroblastoma cells and in APPswe-expressing (Tg2576) mice.
Abstract: In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca²⁺) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the amyloid precursor protein (APP), thereby generating amyloid-β (Aβ) peptides. Here we investigate whether APP contributes to ER Ca²⁺ homeostasis and whether ER Ca²⁺ could in turn influence Aβ production. We show that overexpression of wild-type human APP (APP(695)), or APP harboring the Swedish double mutation (APP(swe)) triggers increased ryanodine receptor (RyR) expression and enhances RyR-mediated ER Ca²⁺ release in SH-SY5Y neuroblastoma cells and in APP(swe)-expressing (Tg2576) mice. Interestingly, dantrolene-induced lowering of RyR-mediated Ca²⁺ release leads to the reduction of both intracellular and extracellular Aβ load in neuroblastoma cells as well as in primary cultured neurons derived from Tg2576 mice. This Aβ reduction can be accounted for by decreased Thr-668-dependent APP phosphorylation and β- and γ-secretases activities. Importantly, dantrolene diminishes Aβ load, reduces Aβ-related histological lesions, and slows down learning and memory deficits in Tg2576 mice. Overall, our data document a key role of RyR in Aβ production and learning and memory performances, and delineate RyR-mediated control of Ca²⁺ homeostasis as a physiological paradigm that could be targeted for innovative therapeutic approaches.

216 citations

Journal ArticleDOI
TL;DR: Pharmacological enhancement of 2-arachidonoyl-sn-glycerol signalling normalizes this synaptic defect and corrects behavioural abnormalities in fragile X mental retardation protein-deficient mice, which might be targeted by therapy.
Abstract: Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain. Fragile X mental retardation protein deletion in mice enhances metabotropic glutamate receptor-5-dependent long-term depression in the hippocampus and cerebellum. Here we show that a distinct type of metabotropic glutamate receptor-5-dependent long-term depression at excitatory synapses of the ventral striatum and prefrontal cortex, which is mediated by the endocannabinoid 2-arachidonoyl- sn-glycerol, is absent in fragile X mental retardation protein-null mice. In these mutants, the macromolecular complex that links metabotropic glutamate receptor-5 to the 2-arachidonoyl- sn-glycerol- producing enzyme, diacylglycerol lipase- α (endocannabinoid signalosome), is disrupted and metabotropic glutamate receptor-5-dependent 2-arachidonoyl- sn-glycerol formation is compromised. These changes are accompanied by impaired endocannabinoid-dependent long-term depression. Pharmacological enhancement of 2-arachidonoyl- sn-glycerol signalling

216 citations

Journal ArticleDOI
TL;DR: In this paper, a fully organic prosthesis for long-term in-vivo subretinal implantation in the eye of Royal College of Surgeons rats, a widely recognized model of retinitis pigmentosa, was presented.
Abstract: The degeneration of photoreceptors in the retina is one of the major causes of adult blindness in humans. Unfortunately, no effective clinical treatments exist for the majority of retinal degenerative disorders. Here we report on the fabrication and functional validation of a fully organic prosthesis for long-term in vivo subretinal implantation in the eye of Royal College of Surgeons rats, a widely recognized model of retinitis pigmentosa. Electrophysiological and behavioural analyses reveal a prosthesis-dependent recovery of light sensitivity and visual acuity that persists up to 6–10 months after surgery. The rescue of the visual function is accompanied by an increase in the basal metabolic activity of the primary visual cortex, as demonstrated by positron emission tomography imaging. Our results highlight the possibility of developing a new generation of fully organic, highly biocompatible and functionally autonomous photovoltaic prostheses for subretinal implants to treat degenerative blindness. A retinal prosthesis fabricated from an organic photovoltaic polymer can restore degenerative blindness in vivo, and over long implantation periods.

215 citations

Journal ArticleDOI
TL;DR: It is shown that microfabricated gears, sitting on a liquid–air interface, can efficiently convert absorbed light into rotational motion through a thermocapillary effect and is shown to be one of the strongest mechanisms for light actuation at the micron- and nanoscale.
Abstract: The direct conversion of light into work allows the driving of micron-sized motors in a contactless, controllable and continuous way. Light-to-work conversion can involve either direct transfer of optical momentum or indirect opto-thermal effects. Both strategies have been implemented using different coupling mechanisms. However, the resulting efficiencies are always very low, and high power densities, generally obtained by focused laser beams, are required. Here we show that microfabricated gears, sitting on a liquid–air interface, can efficiently convert absorbed light into rotational motion through a thermocapillary effect. We demonstrate rotation rates up to 300 r.p.m. under wide-field illumination with incoherent light. Our analysis shows that thermocapillary propulsion is one of the strongest mechanisms for light actuation at the micron- and nanoscale. The direct conversion of light into work allows the control of micromotors, but typically with low efficiencies and high power density requirements. Here, Maggiet al. demonstrate efficient thermocapillary propulsion of microgears on a liquid–air interface with wide-field, incoherent illumination.

214 citations


Authors

Showing all 4601 results

NameH-indexPapersCitations
Marc G. Caron17367499802
Paolo Vineis134108886608
Michele Parrinello13363794674
Alex J. Barker132127384746
Tomaso Poggio13260888676
Shuai Liu129109580823
Giacomo Rizzolatti11729897242
Yehezkel Ben-Ari11045944293
Daniele Piomelli10450549009
Bruno Scrosati10358066572
Wolfgang J. Parak10246943307
Liberato Manna9849444780
Muhammad Imran94305351728
Ole Isacson9334530460
Luigi Ambrosio9376139688
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202313
2022109
20211,576
20201,618
20191,439
20181,381