Institution
Istituto Italiano di Tecnologia
Facility•Genoa, Italy•
About: Istituto Italiano di Tecnologia is a facility organization based out in Genoa, Italy. It is known for research contribution in the topics: Humanoid robot & Robot. The organization has 4561 authors who have published 14595 publications receiving 437558 citations. The organization is also known as: Italian Institute of Technology & IIT.
Topics: Humanoid robot, Robot, Graphene, iCub, Population
Papers published on a yearly basis
Papers
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TL;DR: The data demonstrate that Tregs are committed to survive and proliferate in such a hostile milieu thanks to a metabolic advantage based on the combination of glycolysis and fatty acid synthesis and oxidation, and support a model in which signals from the tumor microenvironment induce a circuitry of glyCOlysis, FA synthesis, and oxidation that confers a preferential proliferative advantage to T Regs.
Abstract: The tumor microenvironment restrains conventional T cell (Tconv) activation while facilitating the expansion of Tregs. Here we showed that Tregs' advantage in the tumor milieu relies on supplemental energetic routes involving lipid metabolism. In murine models, tumor-infiltrating Tregs displayed intracellular lipid accumulation, which was attributable to an increased rate of fatty acid (FA) synthesis. Since the relative advantage in glucose uptake may fuel FA synthesis in intratumoral Tregs, we demonstrated that both glycolytic and oxidative metabolism contribute to Tregs' expansion. We corroborated our data in human tumors showing that Tregs displayed a gene signature oriented toward glycolysis and lipid synthesis. Our data support a model in which signals from the tumor microenvironment induce a circuitry of glycolysis, FA synthesis, and oxidation that confers a preferential proliferative advantage to Tregs, whose targeting might represent a strategy for cancer treatment.
194 citations
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TL;DR: The experimental observation of three-photon interference in an integrated three-port directional coupler realized by ultrafast laser writing is reported, which allows for bosonic coalescence of three photons and opens new important perspectives in many areas of quantum information.
Abstract: The main features of quantum mechanics reside in interference deriving from the superposition of different quantum states. While current quantum optical technology enables two-photon interference both in bulk and integrated systems, simultaneous interference of more than two particles, leading to richer quantum phenomena, is still a challenging task. Here we report the experimental observation of three-photon interference in an integrated three-port directional coupler realized by ultrafast laser writing. By exploiting the capability of this technique to produce three-dimensional structures, we realized and tested in the quantum regime a three-port beam splitter, namely a tritter, which allowed us to observe bosonic coalescence of three photons. These results open new important perspectives in many areas of quantum information, such as fundamental tests of quantum mechanics with increasing number of photons, quantum state engineering, quantum sensing and quantum simulation. For the development and application of quantum technologies, devices capable of implementing more than two-photon processes are vital. Towards this aim, Spagnolo et al.build a three-port beam splitter and demonstrate mutual interference between the three photons.
194 citations
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TL;DR: A novel spike detection algorithm, named Precise Timing Spike Detection (PTSD), aimed at reducing the number of false positives and false negatives, in order to optimize the rate code, and improving the time precision of the identified spike, in terms of efficiency and precision is presented.
193 citations
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TL;DR: Structural inhomogeneity on a micrometer-scale across a CH3NH3PbI3 single crystal is responsible for a local modulation of the optical band gap, which is also highly sensitive to humidity.
Abstract: Here we identify structural inhomogeneity on a micrometer scale across the surface of a CH3NH3PbI3 perovskite single crystal. At the crystal edge a local distortion of the crystal lattice is responsible for a widening of the optical bandgap and faster photo-carrier recombination. These effects are inherently present at the edge of the crystal, and further enhanced upon water intercalation, as a preliminary step in the hydration of the perovskite material.
193 citations
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TL;DR: Results show that MP were accumulated in crustaceans, without affecting mortality, indicating that neurotoxic effects and oxidative stress were induced after MP treatment, and provide new insight into sub-lethal MP effects on marine crustacean.
193 citations
Authors
Showing all 4601 results
Name | H-index | Papers | Citations |
---|---|---|---|
Marc G. Caron | 173 | 674 | 99802 |
Paolo Vineis | 134 | 1088 | 86608 |
Michele Parrinello | 133 | 637 | 94674 |
Alex J. Barker | 132 | 1273 | 84746 |
Tomaso Poggio | 132 | 608 | 88676 |
Shuai Liu | 129 | 1095 | 80823 |
Giacomo Rizzolatti | 117 | 298 | 97242 |
Yehezkel Ben-Ari | 110 | 459 | 44293 |
Daniele Piomelli | 104 | 505 | 49009 |
Bruno Scrosati | 103 | 580 | 66572 |
Wolfgang J. Parak | 102 | 469 | 43307 |
Liberato Manna | 98 | 494 | 44780 |
Muhammad Imran | 94 | 3053 | 51728 |
Ole Isacson | 93 | 345 | 30460 |
Luigi Ambrosio | 93 | 761 | 39688 |