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Institution

Istituto Italiano di Tecnologia

FacilityGenoa, Italy
About: Istituto Italiano di Tecnologia is a facility organization based out in Genoa, Italy. It is known for research contribution in the topics: Humanoid robot & Robot. The organization has 4561 authors who have published 14595 publications receiving 437558 citations. The organization is also known as: Italian Institute of Technology & IIT.
Topics: Humanoid robot, Robot, Graphene, iCub, Population


Papers
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Journal ArticleDOI
TL;DR: It is concluded that the loss of pacemaking was a consequence, rather than a cause, of key network pathophysiology, a conclusion that is consistent with the ability of L-type channel antagonists to attenuate silencing after DA depletion.
Abstract: Parkinson's disease is a common neurodegenerative disorder characterized by a profound motor disability that is traceable to the emergence of synchronous, rhythmic spiking in neurons of the external segment of the globus pallidus (GPe). The origins of this pathophysiology are poorly defined for the generation of pacemaking. After the induction of a parkinsonian state in mice, there was a progressive decline in autonomous GPe pacemaking, which normally serves to desynchronize activity. The loss was attributable to the downregulation of an ion channel that is essential in pacemaking, the hyperpolarization and cyclic nucleotide-gated (HCN) channel. Viral delivery of HCN2 subunits restored pacemaking and reduced burst spiking in GPe neurons. However, the motor disability induced by dopamine (DA) depletion was not reversed, suggesting that the loss of pacemaking was a consequence, rather than a cause, of key network pathophysiology, a conclusion that is consistent with the ability of L-type channel antagonists to attenuate silencing after DA depletion.

175 citations

Journal ArticleDOI
18 May 2012-PLOS ONE
TL;DR: The authors' data show that the observation of motor acts determines a modulation of cortical rhythm analogous to that occurring during motor act execution, and provides strong evidence for the presence in humans of a mechanism (mirror mechanism) mapping action observation on action execution motor programs.
Abstract: Background The observation of action done by others determines a desynchronization of the rhythms recorded from cortical central regions. Here, we examined whether the observation of different types of hand movements (target directed, non-target directed, cyclic and non-cyclic) elicits different EEG cortical temporal patterns.

175 citations

Journal ArticleDOI
TL;DR: The photophysical properties that make GFPs so special as pH indicators for in vivo use are discussed and the probes that are utilized most by the scientific community are described.
Abstract: Green fluorescent protein (GFP) and its variants have been used as fluorescent reporters in a variety of applications for monitoring dynamic processes in cells and organisms, including gene expression, protein localization, and intracellular dynamics GFP fluorescence is stable, species-independent, and can be monitored noninvasively in living cells by fluorescence microscopy, flow cytometry, or macroscopic imaging techniques Owing to the presence of a phenol group on the chromophore, most GFP variants display pH-sensitive absorption and fluorescence bands Such behavior has been exploited to genetically engineer encodable pH indicators for studies of pH regulation within specific intracellular compartments that cannot be probed using conventional pH-sensitive dyes These pH indicators contributed to shedding light on a number of cell functions for which intracellular pH is an important modulator In this review we discuss the photophysical properties that make GFPs so special as pH indicators for in vivo use and we describe the probes that are utilized most by the scientific community

174 citations

Journal ArticleDOI
18 Jun 2014-Neuron
TL;DR: The effectiveness of this approach for multipoint optical stimulation in the mammalian brain in vivo is demonstrated by coupling the fiber to a microelectrode array and performing simultaneous extracellular recording and stimulation at multiple sites in the mouse striatum and cerebral cortex.

174 citations

Journal ArticleDOI
TL;DR: The re-identification performance of HPE is augmented by applying it as human part descriptor, defining a structured feature called asymmetry-based HPE (AHPE), which provides optimal performances against low resolution, occlusions, pose and illumination variations, defining state-of-the-art results on all the considered datasets.

174 citations


Authors

Showing all 4601 results

NameH-indexPapersCitations
Marc G. Caron17367499802
Paolo Vineis134108886608
Michele Parrinello13363794674
Alex J. Barker132127384746
Tomaso Poggio13260888676
Shuai Liu129109580823
Giacomo Rizzolatti11729897242
Yehezkel Ben-Ari11045944293
Daniele Piomelli10450549009
Bruno Scrosati10358066572
Wolfgang J. Parak10246943307
Liberato Manna9849444780
Muhammad Imran94305351728
Ole Isacson9334530460
Luigi Ambrosio9376139688
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202313
2022109
20211,576
20201,618
20191,439
20181,381