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Institution

IT University

About: IT University is a based out in . It is known for research contribution in the topics: Cloud computing & The Internet. The organization has 945 authors who have published 777 publications receiving 16428 citations.


Papers
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Journal ArticleDOI
TL;DR: High-frequency/low-energy gastric electrical stimulation significantly decreased vomiting frequency and gastrointestinal symptoms and improved quality of life in patients with severe gastroparesis.

528 citations

Journal ArticleDOI
TL;DR: The construction of the first complete genetic linkage map of the laboratory rat is reported, identifying 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single SHR × BN F2 intercross.
Abstract: We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR × BN) F2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the markers fall into one of the 21 large linkage groups, the maps appear to cover the vast majority of the rat genome. The availability of the map should facilitate whole genome scans for genes underlying qualitative and quantitative traits relevant to mammalian physiology and pathobiology.

478 citations

Journal ArticleDOI
TL;DR: The high prevalence of oxidative DNA damage in the spermatozoa of male infertility patients may have implications for the health of children conceived in vitro and serves as a driver for current research into the origins of free radical generation in the germ line.
Abstract: One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a result of collateral damage to proteins and lipids in the sperm plasma membrane. The origins of such oxidative stress appear to involve the sperm mitochondria, which have a tendency to generate high levels of superoxide anion as a prelude to entering the intrinsic apoptotic cascade. Unfortunately, these cells have very little capacity to respond to such an attack because they only possess the first enzyme in the base excision repair (BER) pathway, 8-oxoguanine glycosylase 1 (OGG1). The latter successfully creates an abasic site, but the spermatozoa cannot process the oxidative lesion further because they lack the downstream proteins (APE1, XRCC1) needed to complete the repair process. It is the responsibility of the oocyte to continue the BER pathway prior to initiation of S-phase of the first mitotic division. If a mistake is made by the oocyte at this stage of development, a mutation will be created that will be represented in every cell in the body. Such mechanisms may explain the increase in childhood cancers and other diseases observed in the offspring of males who have suffered oxidative stress in their germ line as a consequence of age, environmental or lifestyle factors. The high prevalence of oxidative DNA damage in the spermatozoa of male infertility patients may have implications for the health of children conceived in vitro and serves as a driver for current research into the origins of free radical generation in the germ line.

455 citations

Journal ArticleDOI
TL;DR: This work has confirmed that spermatozoa were the first cell type in which the cellular generation of reactive oxygen was demonstrated and the importance of oxidative damage in the male germ line to the origins of male infertility, early pregnancy loss and childhood disease, deserves attention.
Abstract: Spermatozoa were the first cell type in which the cellular generation of reactive oxygen was demonstrated. This activity has now been confirmed in spermatozoa from all mammalian species examined including the rat, mouse, rabbit, horse, bull and human being. Under physiological circumstances, cellular redox activity is thought to drive the cAMP-mediated, tyrosine phosphorylation events associated with sperm capacitation. In addition to this biological role, human spermatozoa also appear to suffer from oxidative stress, with impacts on the normality of their function and the integrity of their nuclear and mitochondrial DNA. Recent studies have helped to clarify the molecular basis for the intense redox activity observed in defective human spermatozoa, the nature of the subcellular structures responsible for this activity and possible mechanisms by which oxidative stress impacts on these cells. Given the importance of oxidative damage in the male germ line to the origins of male infertility, early pregnancy loss and childhood disease, this area of sperm biochemistry deserves attention from all those interested in improved methods for the diagnosis, management and prevention of male-mediated reproductive failure.

299 citations

Journal ArticleDOI
TL;DR: In this paper, the authors evaluated the reliability of echocardiographic left ventricular (LV) mass measurements in 183 hypertensive patients (68% men, 65 ± 9 years) enrolled in the Prospective Randomized Enalapril Study Evaluating Regression of Ventricular Enlargement (PRESERVE) trial.

296 citations


Authors

Showing all 945 results

NameH-indexPapersCitations
Kaj Blennow1601845116237
Christopher Gillberg13175467561
Biswajeet Pradhan9873532900
Björn Dahlöf9640662129
Ingmar Skoog8945828998
Tomas Albrektsson8927434644
Mats Andersson8374629500
R. John Aitken7220816807
Farid Chemat7133918533
Patricia T. Michie7023222771
Dieu Tien Bui7026014923
Mark Baker6538220285
Jose M. Bioucas-Dias6532627010
Ho Kyong Shon6344814629
Jie Lu6061913509
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20222
202171
202050
201939
201840
201731