Institution
Ivax Corporation
About: Ivax Corporation is a based out in . It is known for research contribution in the topics: Inhaler & Nonlinear regression. The organization has 69 authors who have published 83 publications receiving 1178 citations.
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TL;DR: While intact respiring mitochondria possess powerful antioxidant capability, mPT induces a dysregulated oxidative state with loss of GSH- and NADPH-dependent ROS detoxification and it is proposed that mPT is a significant cause of pathological ROS generation in excitotoxic cell death.
111 citations
TL;DR: Children and adults using the BAI appear to have better asthma control than children and Adults using an MDI as evidenced by fewer relief medication prescriptions and less healthcare resource use.
62 citations
TL;DR: The preparative production of optically pure silybin A and B in a diastereoisomeric purity greater than 95% was accomplished using immobilized Candida antarctica lipase B (Novozym 435) in a combination of two reactions: regioselective acetylation of a natural sily bin mixture and subsequent stereoselectives alcoholysis of the resulting 23- O -acetylsilybin.
52 citations
TL;DR: Nucleotide dimers, such as AZT-P-ddA, should be actively considered for further evaluation as anti-HIV agents.
Abstract: A series of nucleotide homo- and heterodimers [3'-azido-3'-deoxythymidilyl-(5',5')-2',3'-di-deoxy-5' adenylic acid (AZT-P-ddA), 3'-azido-3'-deoxythymidilyl-(5',5')-2', 3'-dideoxy;-5'-adenylic acid, 2-cyanoethyl ester [AZT-P(CyE)-ddA], 3'-azido-3'-deoxythymidilyl-(5',5')-2',3'-dideoxy-5'-inosinic acid (AZT-P-ddI), and 3'-azido-3'-deoxythymidilyl-(5',5')-3'-azido-3'-deoxy-5'-thymid ilic acid (AZT-P-AZT)] were synthesized and compared with respect to their anti-HIV and cytotoxic properties to their component monomers in vitro. MT-2 cells were infected with HIV (TM) followed by the addition of drug. The dimers and their respective monomers inhibited HIV-induced syncytia formation, reverse transcriptase production, and the expression of HIV p24 antigen. However, on an equimolar basis, greater anti-HIV potency and enhanced cytotherapeutic indices were observed with the heterodimers when compared with their monomers. Nucleotide dimers, such as AZT-P-ddA, should be actively considered for further evaluation as anti-HIV agents.
46 citations
TL;DR: In this paper, the mixed dissociation constants of four drug acids (Losartan, paracetamol, phenylephrine and quinine) at various ionic strengths I of range 0.01 and 1.0 and at temperatures of 25 and 37°C were determined using SPECFIT32 and SQUAD(84) regression analysis of the pH-spectrophotometric titration data.
45 citations
Authors
Showing all 69 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ivana Císařová | 40 | 697 | 9604 |
| Alexandr Jegorov | 22 | 175 | 1756 |
| Eva Veverková | 13 | 53 | 459 |
| Ladislav Cvak | 13 | 81 | 923 |
| Ales Vrana | 12 | 18 | 370 |
| Michal Hušák | 12 | 75 | 533 |
| Miroslav Veverka | 11 | 35 | 398 |
| Josef Stuchlik | 10 | 33 | 263 |
| Ales Gavenda | 9 | 35 | 216 |
| Jan Geert Hazenberg | 8 | 36 | 205 |
| Marijke H. Adams | 7 | 8 | 200 |
| Martin Buchta | 7 | 13 | 69 |
| Scott L. Charland | 6 | 12 | 120 |
| Petr Bulej | 5 | 13 | 49 |
| Jiri Faustmann | 5 | 14 | 102 |