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Institution

Jadavpur University

EducationKolkata, India
About: Jadavpur University is a education organization based out in Kolkata, India. It is known for research contribution in the topics: Population & Schiff base. The organization has 10856 authors who have published 27678 publications receiving 422069 citations. The organization is also known as: JU & Jadabpur University.


Papers
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Journal ArticleDOI
TL;DR: In this paper, an attempt has been made to model the white layer depth through response surface methodology (RSM) in a WEDM process comprising a rough cut followed by a trim cut.
Abstract: A white layer is considered a major flaw on a workpiece surface machined with wire-cut electrical discharge machining (WEDM). In this paper, an attempt has been made to model the white layer depth through response surface methodology (RSM) in a WEDM process comprising a rough cut followed by a trim cut. An experimental plan for rotatable central composite design of second order involving four variables with five levels has been employed to carry out the experimental investigation and subsequently to establish the mathematical model correlating the input process parameters with the response. Pulse on time during rough cutting, pulse on time, wire tool offset, and constant cutting speed during trim cutting are considered the dominant input process parameters whilst the white layer depth is the response. An insignificant “lack of fit” term indicated a curve with a good fit. Also, an extensive analysis of the influences of all the individual input parameters on the response has been carried out and presented in this research study.

120 citations

Journal ArticleDOI
TL;DR: The present review aims to recapitulate the research findings on bioactive constituents of natural origin with P-gp inhibition characteristics with great potential for semi-synthetic modification to produce new scaffolds which could serve as valuable investigative tools to recognize the function of complex ABC transporters apart from evading the systemic toxicities shown by synthetic counterparts.
Abstract: Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be responsible for MDR and making the treatment regimens ineffective. In this review, we discuss MDR in relation to P-glycoprotein (P-gp) and its down-regulation by natural bioactive molecules. P-gp, a unique ATP-dependent membrane transport protein, is one of those key regulators which are present in the lining of the colon, endothelial cells of the blood brain barrier (BBB), bile duct, adrenal gland, kidney tubules, small intestine, pancreatic ducts and in many other tissues like heart, lungs, spleen, skeletal muscles, etc. Due to its diverse tissue distribution, P-gp is a novel protective barrier to stop the intake of xenobiotics into the human body. Over-expression of P-gp leads to decreased intracellular accretion of many chemotherapeutic agents thus assisting in the development of MDR. Eventually, the effectiveness of these drugs is decreased. P-gp inhibitors act by altering intracellular ATP levels which are the source of energy and/or by affecting membrane contours to increase permeability. However, the use of synthetic inhibitors is known to cause serious toxicities. For this reason, the search for more potent and less toxic P-gp inhibitors of natural origin is underway. The present review aims to recapitulate the research findings on bioactive constituents of natural origin with P-gp inhibition characteristics. Natural bioactive constituents with P-gp modulating effects offer great potential for semi-synthetic modification to produce new scaffolds which could serve as valuable investigative tools to recognize the function of complex ABC transporters apart from evading the systemic toxicities shown by synthetic counterparts. Despite the many published scientific findings encompassing P-gp inhibitors, however, this article stand alones because it provides a vivid picture to the readers pertaining to Pgp inhibitors obtained from natural sources coupled with their mode of action and structures. It provides first-hand information to the scientists working in the field of drug discovery to further synthesise and discover new P-gp inhibitors with less toxicity and more efficacies.

120 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigate the export-growth relationship at disaggregate levels, focusing on the diversification and the composition of exports of countries and find that diversification of exports matters for gross domestic product growth.
Abstract: We investigate the export-growth relationship at disaggregate levels – disaggregation both at the country level and at the level of exports – focusing on the diversification and the composition of exports of countries. In a sample of 65 countries for the period 1965–2005 the dynamic panel estimation reveals that both diversification and composition of exports are important determinants of economic growth after controlling for the impacts of other variables like lagged income, investment, and infrastructure. There is a critical level of export concentration beyond which increasing export specialization leads to higher growth. Below this critical level, diversification of exports matters for gross domestic product (GDP) growth. Growth of high technology exports also contributes tothe output growth; the relationship becomes stronger for countries that have share of manufacturing exports in their total exports greater than the world average. These results are robust even when the dataset isclassified in four ...

120 citations

Journal ArticleDOI
TL;DR: This paper proposes a new scheme that provides a combined approach of fine-grained access control over cloud-based multiserver data along with a provably secure mobile user authentication mechanism for the Healthcare Industry 4.0.
Abstract: Mobile cloud computing (MCC) allows mobile users to have on-demand access to cloud services. A mobile cloud model helps in analyzing the information regarding the patients’ records and also in extracting recommendations in healthcare applications. In MCC, a fine-grained level access control of multiserver cloud data is a prerequisite for successful execution of end-users applications. In this paper, we propose a new scheme that provides a combined approach of fine-grained access control over cloud-based multiserver data along with a provably secure mobile user authentication mechanism for the Healthcare Industry 4.0. To the best of our knowledge, the proposed scheme is the first to pursue fine-grained data access control over multiple cloud servers in a MCC environment. The proposed scheme has been validated extensively in different heterogeneous environment where its performance was found good in comparison to other existing schemes.

120 citations

Journal ArticleDOI
TL;DR: This paper has described the theoretical background of each software tool including its algorithm and its applicability in the nano-QSAR modeling, and developed a variety of software tools under the NanoBRIDGES project which will assist in performing QSAR and nano-Zoonotic modeling.

120 citations


Authors

Showing all 10999 results

NameH-indexPapersCitations
Subir Sarkar1491542144614
Amartya Sen149689141907
Susumu Kitagawa12580969594
Praveen Kumar88133935718
Rodolphe Clérac7850622604
Rajesh Gupta7893624158
Santanu Bhattacharya6740014039
Swagatam Das6437019153
Anupam Bishayee6223711589
Michael G. B. Drew61131524747
Soujanya Poria5717513352
Madeleine Helliwell543709898
Tapas Kumar Maji542539804
Pulok K. Mukherjee5429610873
Dipankar Chakraborti5411512078
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202385
2022332
20211,949
20201,936
20191,737
20181,807