Jadavpur University

About: Jadavpur University is a education organization based out in Kolkata, India. It is known for research contribution in the topics: Population & Schiff base. The organization has 10856 authors who have published 27678 publications receiving 422069 citations. The organization is also known as: JU & Jadabpur University.

Performance analysis of LDA, QDA and KNN algorithms in left-right limb movement classification from EEG data

Abstract: Brain Computer Interface (BCI) improve the lifestyle of the normal people by enhancing their performance levels. It also provides a way of communication for the disabled people with their surrounding who are otherwise unable to physically communicate. BCI can be used to control computers, robots, prosthetic devices and other assistive technologies for rehabilitation. The dataset used for this study has been obtained from the BCI competition II 2003 databank provided by the University of Technology, Graz. After pre-processing of the signals from their electrodes (C3 & C4), the wavelet coefficients, Power Spectral Density of the alpha and the central beta band and the average power of the respective bands have been employed as features for classification. In one of the approaches we fed all the extracted features individually and in the other approach we considered all features together and submitted them to LDA, QDA and KNN algorithms distinctly to classify left and right limb movement. The aim of this study is to analyze the performance of linear discriminant analysis (LDA), quadratic discriminant analysis (QDA) and K-nearest neighbor (KNN) algorithms in differentiating the raw EEG data obtained, into their associative movement, namely, left-right movement. Also the importance of the feature vectors selected is highlighted in this study. The total set to feature vector comprising all the features (i.e., wavelet coefficients, PSD and average band power estimate) performed better with the classifiers without much deviation in the classification accuracy, i.e., 80%, 80% and 75.71% with LDA, QDA and KNN respectively. Wavelet coefficients performed best with QDA classifier with an accuracy of 80%. PSD vector resulted in superior performance of 81.43% with both QDA and KNN. Average band power estimate vector showed highest accuracy of 84.29% with KNN algorithm. Our approach presented in this paper is quite simple, easy to execute and is validated robustly with a large dataset.

Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers

Abstract: Controlled drug delivery technology of proteins/peptides from biodegradable nanoparticles has emerged as one of the eminent areas to overcome formulation associated problems of the macromolecules. The purpose of the present investigation was to develop protein-loaded nanoparticles using biodegradable polymer poly l-lactide-co-glycolidic acid (PLGA) with bovine serum albumin (BSA) as a model protein. Despite many studies available with PLGA-based protein-loaded nanoparticles, production know-how, process parameters, protein loading, duration of protein release, narrowing polydispersity of particles have not been investigated enough to scale up manufacturing of protein-loaded nanoparticles in formulations. Different process parameters such as protein/polymer ratio, homogenizing speed during emulsifications, particle surface morphology and surface charges, particle size analysis and in-vitro protein release were investigated. The in-vitro protein release study suggests that release profile of BSA from nanoparticles could be modulated by changing protein-polymer ratios and/or by varying homogenizing speed during multiple-emulsion preparation technique. The formulation prepared with protein-polymer ratio of 1:60 at 17,500 rpm gave maximum protein-loading, minimum polydispersion with maximally sustained protein release pattern, among the prepared formulations. Decreased (10,000 rpm) or enhanced (24,000 rpm) homogenizing speeds resulted in increased polydispersion with larger particles having no better protein-loading and -release profiles in the present study.