Jadavpur University

About: Jadavpur University is a education organization based out in Kolkata, India. It is known for research contribution in the topics: Population & Fuzzy logic. The organization has 10856 authors who have published 27678 publications receiving 422069 citations. The organization is also known as: JU & Jadabpur University.

Influence of rock types and structures in the development of drainage network in hard rock area

Abstract: Remote sensing techniques has proved to be an extremely useful tool in morphometric analysis and groundwater studies. Remote sensing techniques with an emphasis on lineament identifications can play a great role in groundwater prospecting in semi-arid hard rock areas of Purulia district. In the present study, morphometric analysis using remote sensing technique has been carried out in parts of Baghmundi block, Purulia district, West Bengal. The parameters worked out include Bifurcation ratio (Rb), Stream length (Lu), Form factor (Rc), Circulatory ratio (Rc), and Drainage density (D). The morphometric analysis suggests that fractured, resistant, permeable rocks cover the area, the drainage network not so affected by tectonic disturbances. Using satellite imageries of two dates of IRS, different hydrogeomorphological units have been delineated. Among different hydrogeomorphic units (i) very shallow weathered pediment and (ii) Structural hills/ residual hills/inselbergs have very poor ground water prospects, while moderately weathered pediplains and valley fills are good prospective zones for groundwater exploration.

Elastic and other associated properties of C 60

Abstract: Considering that Coulomb interactions contribute a negligible amount to the cohesive energy in ${\mathrm{C}}_{60}$, which has an fcc structure at room temperature, we used Girifalco potential function in our calculations; ${\mathrm{C}}_{60}$ is spherical in nature and rotates rather freely at room temperature. From this potential we evaluated the second-order elastic constants (SOEC's), their pressure derivatives, and the third-order elastic constants (TOEC's). The SOEC's are found to be in good agreement with other literature values reported so far. The pressure derivative of bulk modulus is found to be 3.8 which compares favorably with Duclos values while the theoretical literature value is reported to be high. The pressure derivatives of the SOEC's are found to be high compared with those of glassy, amorphous materials, alloys, and metals. Furthermore, the derivatives are all found to be positive. The TOEC's are all found to be negative resembling those of polymers like polystyrene. We evaluated the thermal Gruneisen's constant from the potential function and the value obtained is in excellent agreement with experiment.

Development of the human cancer microRNA network

Abstract: MicroRNAs are a class of small noncoding RNAs that are abnormally expressed in different cancer cells. Molecular signature of miRNAs in different malignancies suggests that these are not only actively involved in the pathogenesis of human cancer but also have a significant role in patients survival. The differential expression patterns of specific miRNAs in a specific cancer tissue type have been reported in hundreds of research articles. However limited attempt has been made to collate this multitude of information and obtain a global perspective of miRNA dysregulation in multiple cancer types. In this article a cancer-miRNA network is developed by mining the literature of experimentally verified cancer-miRNA relationships. This network throws up several new and interesting biological insights which were not evident in individual experiments, but become evident when studied in the global perspective. From the network a number of cancer-miRNA modules have been identified based on a computational approach to mine associations between cancer types and miRNAs. The modules that are generated based on these association are found to have a number of common predicted target onco/tumor suppressor genes. This suggests a combinatorial effect of the module associated miRNAs on target gene regulation in selective cancer tissues or cell lines. Moreover, neighboring miRNAs (group of miRNAs that are located within 50 kb of genomic location) of these modules show similar dysregulation patterns suggesting common regulatory pathway. Besides this, neighboring miRNAs may also show a similar dysregulation patterns (differentially coexpressed) in the cancer tissues. In this study, we found that in 67% of the cancer types have at least two neighboring miRNAs showing downregulation which is statistically significant (P < 10-7, Randomization test). A similar result is obtained for the neighboring miRNAs showing upregulation in specific cancer type. These results elucidate the fact that the neighboring miRNAs might be differentially coexpressed in cancer tissues as that of the normal tissue types. Additionally, cancer-miRNA network efficiently detect hub miRNAs dysregulated in many cancer types and identify cancer specific miRNAs. Depending on the expression patterns, it is possible to identify those hubs that have strong oncogenic or tumor suppressor characteristics. Limited work has been done towards revealing the fact that a number of miRNAs can control commonly altered regulatory pathways. However, this becomes immediately evident by accompanying the analysis of cancer-miRNA relationships in the proposed network model. These raise many unaddressed issues in miRNA research that have never been reported previously. These observations are expected to have an intense implication in cancer and may be useful for further research.