Jagiellonian University

About: Jagiellonian University is a education organization based out in Krakow, Poland. It is known for research contribution in the topics: Population & Catalysis. The organization has 17438 authors who have published 44092 publications receiving 862633 citations. The organization is also known as: Academia Cracoviensis & Akademia Krakowska.

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1

Abstract: Blockade of the PD-1/PD-L1 immune checkpoint pathway with monoclonal antibodies has provided significant advances in cancer treatment. The antibody-based immunotherapies carry a number of disadvantages such as the high cost of the antibodies, their limited half-life, and immunogenicity. Development of small-molecule PD-1/PD-L1 inhibitors that could overcome these drawbacks is slow because of the incomplete structural information for this pathway. The first chemical PD-1/PD-L1 inhibitors have been recently disclosed by Bristol-Myers Squibb. Here we present NMR and X-ray characterization for the two classes of these inhibitors. The X-ray structures of the PD-L1/inhibitor complexes reveal one inhibitor molecule located at the center of the PD-L1 homodimer, filling a deep hydrophobic channel-like pocket between two PD-L1 molecules. Derivatives of (2-methyl-3-biphenylyl)methanol exhibit the structures capped on one side of the channel, whereas the compounds based on [3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-meth...

Complete set of precise deuteron analyzing powers at intermediate energies: Comparison with modern nuclear force predictions

Abstract: Precise measurements of deuteron vector and tensor analyzing powers ${A}_{y}^{d},$ ${A}_{\mathrm{xx}},$ ${A}_{\mathrm{yy}},$ and ${A}_{\mathrm{xz}}$ in $d\ensuremath{-}p$ elastic scattering were performed via ${}^{1}\mathrm{H}(\stackrel{\ensuremath{\rightarrow}}{d},d)p$ and ${}^{1}\mathrm{H}(\stackrel{\ensuremath{\rightarrow}}{d},p)d$ reactions at three incoming deuteron energies of ${E}_{d}^{\mathrm{lab}}=140,$ 200, and $270 \mathrm{MeV}.$ A wide range of center-of-mass angles from $\ensuremath{\approx}10\ifmmode^\circ\else\textdegree\fi{}$ to $180\ifmmode^\circ\else\textdegree\fi{}$ was covered. The cross section was measured at 140 and 270 MeV at the same angles. These high precision data were compared with theoretical predictions based on exact solutions of three-nucleon Faddeev equations and modern nucleon-nucleon potentials combined with three-nucleon forces. Three-body interactions representing a wide range of present day models have been used: the Tucson-Melbourne $2\ensuremath{\pi}$-exchange model, a modification thereof closer to chiral symmetry, the Urbana IX model, and a phenomenological spin-orbit ansatz. Large three-nucleon force effects are predicted, especially at the two higher energies. However, only some of them, predominantly $d\ensuremath{\sigma}/d\ensuremath{\Omega}$ and ${A}_{y}^{d},$ are supported by the present data. For tensor analyzing powers the predicted effects are in drastic conflict to the data, indicating defects of the present day three-nucleon force models.

A new method for assessing 24-h blood pressure variability after excluding the contribution of nocturnal blood pressure fall

Abstract: ObjectivesTo assess quantitatively the relationship between nocturnal blood pressure (BP) fall and 24-h BP variability; to propose a new method for computing 24-h BP variability, devoid of the contribution from nocturnal BP fall; and to verify the clinical value of this method.Methods and resultsWe

Search for Higgs boson pair production in the γ γ bb¯ final state with 13 TeV pp collision data collected by the ATLAS experiment

Abstract: A search is performed for resonant and non-resonant Higgs boson pair production in the $ \upgamma \upgamma b\overline{b} $ final state. The data set used corresponds to an integrated luminosity of 36.1 fb$^{−1}$ of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. No significant excess relative to the Standard Model expectation is observed. The observed limit on the non-resonant Higgs boson pair cross-section is 0.73 pb at 95% confidence level. This observed limit is equivalent to 22 times the predicted Standard Model cross-section. The Higgs boson self-coupling (κ$_{λ}$ = λ$_{HHH}$/λ$_{HHH}^{SM}$ ) is constrained at 95% confidence level to −8.2 < κ$_{λ}$ < 13.2. For resonant Higgs boson pair production through $ X\to HH\to \upgamma \upgamma b\overline{b} $ , the limit is presented, using the narrow-width approximation, as a function of m$_{X}$ in the range 260 GeV < m$_{X}$ < 1000 GeV. The observed limits range from 1.1 pb to 0.12 pb over this mass range.