Institution
Jagiellonian University
Education•Krakow, Poland•
About: Jagiellonian University is a education organization based out in Krakow, Poland. It is known for research contribution in the topics: Population & Catalysis. The organization has 17438 authors who have published 44092 publications receiving 862633 citations. The organization is also known as: Academia Cracoviensis & Akademia Krakowska.
Topics: Population, Catalysis, Large Hadron Collider, Galaxy, European union
Papers published on a yearly basis
Papers
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TL;DR: Data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.
Abstract: Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3(-/-) cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor or its functions within the ETC. In mice that do not express Stat3 in the heart, there were also selective defects in the activities of complexes I and II of the ETC. These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.
885 citations
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882 citations
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TL;DR: In this paper, a fusion of Tet1 or Dnmt3a with a catalytically inactive Cas9 (dCas9) enables targeted DNA methylation editing, which is a critical epigenetic mechanism orchestrating gene expression networks in many biological processes.
869 citations
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TL;DR: A full understanding of melanin function, and indeed its role in retarding or promoting the disease state, can only be obtained through a full mapping of key structure-property relationships in the main pigment types.
Abstract: In this article, we review the current state of knowledge concerning the physical and chemical properties of the eumelanin pigment. We examine properties related to its photoprotective functionality, and draw the crucial link between fundamental molecular structure and observable macroscopic behaviour. Where necessary, we also briefly review certain aspects of the pheomelanin literature to draw relevant comparison. A full understanding of melanin function, and indeed its role in retarding or promoting the disease state, can only be obtained through a full mapping of key structure-property relationships in the main pigment types. We are engaged in such an endeavor for the case of eumelanin.
860 citations
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University of Amsterdam1, Ghent University2, Imperial College London3, Charité4, University of Montpellier5, Medical University of Silesia6, Karolinska Institutet7, Umeå University8, Uppsala University9, Jagiellonian University10, University of Düsseldorf11, Medical University of Łódź12, Odense University Hospital13, University of Gothenburg14, University of Southampton15, Children's Hospital of Philadelphia16
TL;DR: This data indicates that rhinosinusitis in Europe is an underestimated disease, and the number of patients diagnosed with the disease and the severity of the disease should be increased.
Abstract: Background: Chronic rhinosinusitis (CRS) is a common health problem, with significant medical costs and impact on general health. Even so, prevalence figures for Europe are unavailable. In this st ...
812 citations
Authors
Showing all 17729 results
Name | H-index | Papers | Citations |
---|---|---|---|
Roxana Mehran | 141 | 1378 | 99398 |
Brad Abbott | 137 | 1566 | 98604 |
M. Morii | 134 | 1664 | 102074 |
M. Franklin | 134 | 1581 | 95304 |
John Huth | 131 | 1087 | 85341 |
Wladyslaw Dabrowski | 129 | 990 | 79728 |
Rostislav Konoplich | 128 | 811 | 73790 |
Michel Vetterli | 128 | 901 | 76064 |
Francois Corriveau | 128 | 1022 | 75729 |
Christoph Falk Anders | 126 | 734 | 68828 |
Tomasz Bulik | 121 | 698 | 86211 |
Elzbieta Richter-Was | 118 | 793 | 69127 |
S. H. Robertson | 116 | 1311 | 58582 |
S. J. Chen | 116 | 1559 | 62804 |
David M. Stern | 107 | 271 | 47461 |