Institution
Jagiellonian University
Education•Krakow, Poland•
About: Jagiellonian University is a education organization based out in Krakow, Poland. It is known for research contribution in the topics: Population & Catalysis. The organization has 17438 authors who have published 44092 publications receiving 862633 citations. The organization is also known as: Academia Cracoviensis & Akademia Krakowska.
Topics: Population, Catalysis, Large Hadron Collider, Galaxy, European union
Papers published on a yearly basis
Papers
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TL;DR: It is shown that intra-hippocampal infusions of the protein synthesis inhibitor anisomycin caused amnesia for a consolidated hippocampal-dependent contextual fear memory, but only if the memory was reactivated prior to infusion.
726 citations
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TL;DR: In this article, 26 proteins of different structure, function and properties were investigated by Raman spectroscopy with 488, 532 and 1064 nm laser lines, and the excitation lines were chosen in NIR and Vis range as the most common and to show the difference due to normal and resonance effect, sometimes accompanied by the fluorescence.
Abstract: In this work, 26 proteins of different structure, function and properties are investigated by Raman spectroscopy with 488, 532 and 1064 nm laser lines. The excitation lines were chosen in NIR and Vis range as the most common and to show the difference due to normal and resonance effect, sometimes accompanied by the fluorescence. The selected proteins were divided, according to the Structural Classification of Proteins, into four classes according to their secondary structure, i.e. α-helical (α), β-sheet (β), mixed structures (α/β, α + β, s) and others. For all compounds, FT-Raman and two Vis spectra are presented along with the detailed band assignment. To the best of our knowledge, this is the first review showing the potential of Raman spectroscopy for the measurement and analysis of such a large collection of individual proteins. This work can serve as a comprehensive vibrational spectra library, based on our and previous Raman measurements. Copyright © 2013 John Wiley & Sons, Ltd.
725 citations
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TL;DR: It is found that the minimum conductivity of order e2/h at the Dirac point (when the electron and hole excitations are degenerate) is associated with a maximum of the Fano factor (the ratio of noise power and mean current).
Abstract: We calculate the mode-dependent transmission probability of massless Dirac fermions through an ideal strip of graphene (length $L$, width $W$, no impurities or defects) to obtain the conductance and shot noise as a function of Fermi energy. We find that the minimum conductivity of order ${e}^{2}/h$ at the Dirac point (when the electron and hole excitations are degenerate) is associated with a maximum of the Fano factor (the ratio of noise power and mean current). For short and wide graphene strips the Fano factor at the Dirac point equals $1/3$, 3 times smaller than for a Poisson process. This is the same value as for a disordered metal, which is remarkable since the classical dynamics of the Dirac fermions is ballistic.
724 citations
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TL;DR: In this paper, 13 time interval maps were constructed, which depict the Triassic to Neogene plate tectonic configuration, paleogeography and general lithofacies of the southern margin of Eurasia.
712 citations
01 Sep 2016
TL;DR: Fusion of Tet1 or Dnmt3a with a catalytically inactive Cas9 enables targeted DNA methylation editing and these tools can editDNA methylation in mice, demonstrating their wide utility for functional studies of epigenetic regulation.
Abstract: Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene expression networks in many biological processes. However, investigation of the functions of specific methylation events remains challenging. Here, we demonstrate that fusion of Tet1 or Dnmt3a with a catalytically inactive Cas9 (dCas9) enables targeted DNA methylation editing. Targeting of the dCas9-Tet1 or -Dnmt3a fusion protein to methylated or unmethylated promoter sequences caused activation or silencing, respectively, of an endogenous reporter. Targeted demethylation of the BDNF promoter IV or the MyoD distal enhancer by dCas9-Tet1 induced BDNF expression in post-mitotic neurons or activated MyoD facilitating reprogramming of fibroblasts into myoblasts, respectively. Targeted de novo methylation of a CTCF loop anchor site by dCas9-Dnmt3a blocked CTCF binding and interfered with DNA looping, causing altered gene expression in the neighboring loop. Finally, we show that these tools can edit DNA methylation in mice, demonstrating their wide utility for functional studies of epigenetic regulation.
710 citations
Authors
Showing all 17729 results
Name | H-index | Papers | Citations |
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Roxana Mehran | 141 | 1378 | 99398 |
Brad Abbott | 137 | 1566 | 98604 |
M. Morii | 134 | 1664 | 102074 |
M. Franklin | 134 | 1581 | 95304 |
John Huth | 131 | 1087 | 85341 |
Wladyslaw Dabrowski | 129 | 990 | 79728 |
Rostislav Konoplich | 128 | 811 | 73790 |
Michel Vetterli | 128 | 901 | 76064 |
Francois Corriveau | 128 | 1022 | 75729 |
Christoph Falk Anders | 126 | 734 | 68828 |
Tomasz Bulik | 121 | 698 | 86211 |
Elzbieta Richter-Was | 118 | 793 | 69127 |
S. H. Robertson | 116 | 1311 | 58582 |
S. J. Chen | 116 | 1559 | 62804 |
David M. Stern | 107 | 271 | 47461 |